Putting science into persistence, bioaccumulation, and toxicity evaluations

Environmental Toxicology and Chemistry

Volumn 23, Issue 10, 2004, Pages 2473-2482

  Webster, Eva ^a   Cowan Ellsberry, Christina E ^b   McCarty, Lynn ^c  

^a TRENT UNIVERSITY   (Canada)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c LS McCarty Scientific Research and Consulting   (Canada)

Author keywords

Bioaccumulation; Long range transport; Model; Persistence; Toxicity

Indexed keywords

HEALTH CARE; ORGANIC CHEMICALS; POLLUTION;

HUMAN HEALTH; ORGANIC POLLUTANTS;

TOXICITY;

ATRAZINE; BENZO[A]PYRENE; HEXACHLOROBENZENE; TETRACHLOROETHYLENE;

ASSESSMENT METHOD; BIOACCUMULATION; LONG RANGE TRANSPORT; METHODOLOGY; PERSISTENCE; TOXICITY;

ANALYTIC METHOD; BIOACCUMULATION; DRUG IDENTIFICATION; ECOTOXICITY; ENVIRONMENTAL IMPACT; EVALUATION; HEALTH CARE POLICY; HISTORY OF MEDICINE; MATHEMATICAL ANALYSIS; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; PROCESS MONITORING; REVIEW; RISK ASSESSMENT; TOXICITY TESTING;

ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; ORGANIC CHEMICALS; RISK ASSESSMENT; TERMINOLOGY; TISSUE DISTRIBUTION;

EID: 4644242436     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/03-434     Document Type: Review

References (79)

1. Carson R. 1962. Silent Spring. Houghton Mifflin, New York, NY, USA.
2. Mackay D. 1979. Finding fugacity feasible. Environ Sci Technol 13:1218-1223.
3. Mackay D. 1991. Multimedia Environmental Models: The Fugacity Approach. Lewis, Boca Raton, FL, USA.
4. Mackay D. 2001. Multimedia Environmental Models: The Fugacity Approach, 2nd ed. Lewis, Boca Raton, FL, USA.
5. Mackay D. 1989. Modeling the long-term behavior of an organic contaminant in a large lake: Application to PCBs in Lake Ontario. J Gt Lakes Res 15:283-297.
6. Harner T, Mackay D, Jones KC. 1995. Model of the long-term exchange of PCBs between soil and the atmosphere in the southern UK. Environ Sci Technol 29:1200-1209.
7. Webster E, Mackay D, Qiang K. 1999. Equilibrium lipid partitioning concentrations as a multi-media synoptic indicator of contaminant levels and trends in aquatic ecosystems. J Gt Lakes Res 25:318-329.
8. Environment Canada. 1995. Toxic substances management policy: Persistence and bioaccumulation criteria. Final Report of the Ad Hoc Science Group on Criteria. Ottawa, ON.
9. Webster E, Mackay D, Wania F. 1998. Evaluating environmental persistence. Environ Toxicol Chem 17:2148-2158.
10. van de Meent D, McKone TE, Parkerton T, Matthies M, Scheringer M, Wania F, Purdy R, Bennett DH. 2000. Persistence and transport potential of chemicals in a multimedia environment. In Klecka G, Mackay D, eds, Evaluation of Persistence and Long-Range Transport of Organic Chemicals in the Environment. SE-TAC, Pensacola, FL, USA, pp 169-204.
11. Mackay D, Webster E, Beyer A, Matthies M, Wania F. 2001. Defining the bioaccumulation, persistence, and transport attributes of priority chemicals. In Lipnick R, Jansson B, Mackay D, Petreas M, eds, Persistent, Bioaccumulative, and Toxic Chemicals, Vol 2 - Assessment and New Chemicals. ACS 773. American Chemical Society, Washington, DC, pp 14-28.
12. Government of Canada. 1999. Canadian Environmental Protection Act (1999, c. 33). Ottawa, ON.
13. Wania F, Mackay D. 1997. Global distillation. Our Planet: The United Nations Environment Programme Magazine for Environmentally Sustainable Development 8:15-16.
14. Gouin T, Mackay D, Webster E, Wania F. 2000. Screening chemicals for persistence in the environment. Environ Sci Technol 34: 881-884.
15. Woodfine D. Mackay D. 2001. Evaluation of partitioning and persistence of organic substances on Environment Canada's domestic substances list. CEMC Report 200105. Trent University, Peterborough, ON.
16. Environment Canada. 2002. Multistakeholder technical workshop DSL categorization approach - October 30-31, 2002. Workshop Report. Gatineau, PQ.
17. Environment Canada. 2003. Guidance Manual for the Categorization of Organic and Inorganic Substances on Canada's Domestic Substances List. Existing Substances Branch, Gatineau, PQ.
18. Mackay D, Sharpe S, Cahill T, Gouin T, Cousins I, Toose L. 2001. Assessing the environmental persistence of a variety of chemical substances including metals. CEMC Report 200104. Trent University, Peterborough, ON, Canada.
19. Mackay D, Webster E, Woodfine D, Cahill T, Doyle P, Couillard Y, Gutzman D. 2003. Towards consistent evaluation of the persistence of organic, inorganic, and metallic substances. Human and Ecological Risk Assessment 9:1445-1474.
20. Swain W. 1978. Chlorinated organic residues in fish, water, and precipitation from the vicinity of Isle Royale, Lake Superior. J Gt Lakes Res 4:398-407.
21. Veith GD, Kuehl DW, Puglish FA, Galss GR, Eaton JG. 1977. Residues of PCBs and DDT in the western Lake Superior ecosystem. Arch Environ Contam Toxicol 5:487-499.
22. Eisenreich SJ, ed. 1981. Atmospheric Pollutants in Natural Waters. Ann Arbor Science, Ann Arbor, MI, USA.
23. Bowes GW, Jonkel CJ. 1975. Presence and distribution of polychlorinated biphenyls (PCB) in Arctic and subarctic marine food chains. J Fish Res Board Can 32:2111-2123.
24. Clausen J, Berg O. 1975. The content of polychlorinated hydrocarbons in Arctic ecosystems. Pure Appl Chem 42:223-232.
25. Hoff RM, Chan K. 1986. Atmospheric concentrations of chlordane at Mould Bay, NWT. Chemosphere 15:449-452.
26. Eisenreich SJ, Hollod G, Johnson TC. 1981. Atmospheric concentrations and deposition of PBCs to Lake Superior. In Eisenreich SJ, ed, Atmospheric Pollutants in Natural Waters. Ann Arbor Science, Ann Arbor, MI, USA, pp 425-444.
27. Oehme M, Ottar B. 1984. The long-range transport of polychlorinated hydrocarbons in the Arctic. Geophysical Research Letters 11:1133-1136.
28. Wania F, Mackay D. 1993. Global fractionation and cold condensation of low volatile organochlorine compounds in polar regions. Ambio 22:10-18.
29. Wania F, Mackay D. 1993. Modeling the global distribution of toxaphene: A discussion of feasibility and desirability. Chemosphere 27:2079-2094.
30. Wania F, Mackay D. 1995. A global distribution model for persistent organic chemicals. Sci Total Environ 160/161:211-232.
31. Wania F, Mackay D. 1996. Tracking the distribution of persistent organic pollutants. Environ Sci Technol 30:390A-396A.
32. Wania F, Mackay D. 1999. Global chemical fate of α- hexachlorocyclohexane. 2. Use of a global distribution model for mass balancing, source apportionment, and trend prediction. Environ Toxicol Chem 18:1400-1407.
33. Wania F, Pacyna JM, Mackay D. 1997. Global fate of persistent organic pollutants. Toxicol Environ Chem 66:81-89.
34. Wania F, Mackay D, Li YF, Bidleman TF, Strand A. 1999. Global chemical fate of α-hexachlorocyclohexane. 1. Modification and evaluation of a global distribution model. Environ Toxicol Chem 18:1390-1399.
35. Scheringer M. 1996. Persistence and spatial range as endpoints of an exposure-based assessment of organic chemicals. Environ Sci Technol 30:1652-1659.
36. Scheringer M. 1997. Characterization of the environmental distribution behavior of organic chemicals by means of persistence and spatial range. Environ Sci Technol 31:2891-2897.
37. Scheringer M, Wegmann F, Fenner K, Hungerbühler K. 2000. Investigation of the cold condensation of persistent organic pollutants with a global multimedia fate model. Environ Sci Technol 34:1842-1850.
38. Van Pul WAJ, de Leeuw FAAM, van Jaarsveld JA, van der Gaag MA, Sliggers CJ. 1998. The potential for long-range transboundary atmospheric transport. Chemosphere 37:113-141.
39. Bennett DH, McKone TE, Matthies M, Kastenberg WE. 1998. General formulation of characteristic travel distance for semivolatile organic chemicals in a multimedia environment. Environ Sci Technol 32:4023-4030.
40. Beyer A, Mackay D, Matthies M, Wania F, Webster E. 2000. Assessing long-range transport potential of persistent organic pollutants. Environ Sci Technol 34:699-703.
41. Gouin T. 2003. Long-range transport of organic contaminants: The role of air-surface exchange. Masters thesis. Trent University, Peterborough, ON, Canada.
42. Webster E, Hubbarde J, Mackay D, Swanston L, Hodge A. 2003. Development of tools to improve exposure estimation for use in ecological risk assessment: The TaPL3 upgrade. CEMC Report 200303. Trent University, Peterborough, ON, Canada.
43. MacLeod M, Woodfine D, Mackay D, McKone T, Bennett D, Maddalena R. 2001. BETR North America: A regionally segmented multimedia contaminant fate model for North America. Environ Sci Pollut Res Int 8:156-163.
44. MacLeod M, Woodfine D, Brimacombe JR, Toose L, Mackay D. 2002. A dynamic mass budget for toxaphene in North America. Environ Toxicol Chem 21:1628-1637.
45. Gobas FAPC, Morrison HA. 2000. Bioconcentration and biomagnification in the aquatic environment. In Boethling RS, Mackay D, eds, Handbook of Property Estimation Methods for Chemicals: Environmental and Health Sciences. Lewis, Boca Raton, FL, USA, pp 189-231.
46. Mackay D, Fraser A. 2000. Bioaccumulation of persistent organic chemicals: Mechanisms and models. Environ Pollut 110:375-391.
47. Mackay D. 1982. Correlation of bioconcentration factors. Environ Sci Technol 16:274-278.
48. Veith GD, Defoe DL, Bergstaedt BV. 1979. Measuring and estimating the bioconcentration factor of chemicals in fish. Fish Res Board Can 36:1040.
49. European Commission. 1996. Technical guidance document in support of commission directive 93/67/EEC on risk assessment for new notified substances and commission regulation (EC) No. 1488/94 on risk assessment for existing substances. Luxembourg, Luxembourg.
50. Mackay D, Hughes AI. 1984. Three-parameter equation describing the uptake of organic compounds by fish. Environ Sci Technol 18:439-444.
51. Gobas FAPC, Mackay D. 1987. Dynamics of hydrophobic organic chemical bioconcentration in fish. Environ Toxicol Chem 6:495-504.
52. Gobas FAPC, Muir DCG, Mackay D. 1988. Dynamics of dietary bioaccumulation and fecal elimination of hydrophobic organic chemicals in fish. Chemosphere 17:943-962.
53. Gobas FAPC, Clark KE, Shiu WY, Mackay D. 1989. Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish: Role of bioavailability and elimination in feces. Environ Toxicol Chem 8:231-245.
54. Hellou J, Mackay D, Fowler B. 1995. Bioconcentration of polycyclic aromatic compounds from sediments to muscle of finfish. Environ Sci Technol 29:2555-2560.
55. Gobas FAPC, Zhang X, Wells R. 1993. Gastrointestinal magnification: The mechanism of biomagnification and food-chain accumulation of organic chemicals. Environ Sci Technol 27:2855-2863.
56. Gobas FAPC, Wilcockson JWB, Russell RW, Haffner GD. 1999. Mechanism of biomagnification in fish under laboratory and field conditions. Environ Sci Technol 33:133-141.
57. Fraser AJ, Burkow IC, Wolkers H, Mackay D. 2002. Modeling biomagnification and metabolism of contaminants in Harp seals of the Barents Sea. Environ Toxicol Chem 21:55-61.
58. Clark KE, Mackay D. 1991. Dietary uptake and biomagnification of four chlorinated hydrocarbons by guppies. Environ Toxicol Chem 10:1205-1217.
59. Paterson S, Mackay D. 1986. A pharmacokinetic model of styrene inhalation using the fugacity approach. Toxicol Appl Pharmacol 82:444-453.
60. Paterson S, Mackay D. 1987. A steady-state fugacity based pharmacokinetic model with simultaneous multiple exposure routes. Environ Toxicol Chem 6:395-408.
61. Hickie BE, Mackay D, de Koning J. 1999. Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals. Environ Toxicol Chem 18:2622-2633.
62. Cahill T, Cousins I, Mackay D. 2003. Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants. Environ Toxicol Chem 22:26-34.
63. Bentzen E, Lean DRS, Taylor WD, Mackay D. 1996. Role of food-web structure on lipid and bioaccumulation of organic contaminants by lake trout (Salvelinus namaycush). Can J Aquat Sci 53:2397-2407.
64. Campfens J, Mackay D. 1997. Fugacity-based model of PCB bioaccumulation in complex aquatic food webs. Environ Sci Technol 31:577-583.
65. Sharpe S, Mackay D. 2000. A framework for evaluating bioaccumulation in food webs. Environ Sci Technol 34:2373-2379.
66. Thomann RV, Connolly JP, Parkerton T. 1991. Modeling accumulation of organic chemicals in aquatic food webs. In Gobas FAPC, McCorquodale JA, eds, Chemical Dynamics in Fresh Water Ecosystems. CRC, Boca Raton, FL, USA, pp 54-67.
67. Thomann RV, Connolly JP, Parkerton T. 1992. An equilibrium model of organic chemical accumulation in aquatic food webs with sediment interaction. Environ Toxicol Chem 11:615-629.
68. Kelly BC, Gobas FAPC. 2001. Bioaccumulation of persistent organic pollutants in lichen-caribou-wolf food chains of Canada's Central and Western Arctic. Environ Sci Technol 35:325-334.
69. McLachlan MS. 1996. Bioaccumulation of hydrophobic chemicals in agricultural food chains. Environ Sci Technol 30:252-259.
70. Mackay D, McCarty LS, MacLeod M. 2001. On the validity of classifying chemicals for persistence, bioaccumulation, toxicity, and potential for long range transport. Environ Toxicol Chem 20: 1491-1498.
71. McCarty LS. 1986. The relationship between aquatic toxicity QSARs and bioconcentration for some organic chemicals. Environ Toxicol Chem 5:1071-1080.
72. Sijm DTHM, Opperhuizen A. 1988. Biotransformation, bioaccumulation and lethality of 2,8-dichlorodibenzo-p-dixoin: A proposal to explain the biotic fate and toxicity of PCDDs and PCDFs. Chemosphere 17:83-99.
73. Van Hoogen G, Opperhuizen A. 1988. Toxicokinetics of chlorobenzenes in fish. Environ Toxicol Chem 7:213-219.
74. Abernethy SG, Mackay D, McCarty LS. 1988. "Volume fraction" correlation for narcosis in aquatic organisms: The key role of partitioning. Environ Toxicol Chem 7:469-481.
75. Abernethy S, Bobra AM, Shiu WY, Wells PG, Mackay D. 1986. Acute lethal toxicity of hydrocarbons and chlorinated hydrocarbons to two planktonic crustaceans: The key role of organism-water partitioning. Aquat Toxicol 8:163-174.
76. McCarty LS, Mackay D, Smith AD, Ozburn GW, Dixon DG. 1991. Interpreting aquatic toxicity QSARs: The significance of toxicant body residues at the pharmacologic endpoint. Sci Total Environ 109/110:515-525.
77. McCarty LS, Mackay D, Smith AD, Ozburn GW, Dixon DG. 1992. Residue-based interpretation of toxicity and bioconcentration QSARs from aquatic bioassays: Neutral narcotic organics. Environ Toxicol Chem 11:917-930.
78. Mackay D, Puig H, McCarty LS. 1992. An equation describing the time course and variability in uptake and toxicity of narcotic chemicals to fish. Environ Toxicol Chem 11:941-951.
79. McCarty LS, Mackay D. 1993. Enhancing ecotoxicological modeling and assessment: Body residues and modes of toxic action. Environ Sci Technol 27:1719-1728.