Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: An analysis using spectral karyotyping

Cancer Genetics and Cytogenetics

Volumn 153, Issue 1, 2004, Pages 39-47

  Martínez Ramírez, Angel ^a   Urioste, Miguel ^a   Alvarez, Sara ^a   Luis Vizmanos, José ^b   José Calasanz, Maria ^b   Cruz Cigudosa, Juan ^a   Benítez, Javier ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 11Q; CHROMOSOME 12Q; CHROMOSOME 18; CHROMOSOME 5; CHROMOSOME 5Q; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DIPLOIDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; MALE; MONOSOMY; MYELODYSPLASTIC SYNDROME; ONCOGENE NEU; PRIORITY JOURNAL; SPECTRAL KARYOTYPING; TRISOMY; ANEUPLOIDY; CHROMOSOME ABERRATION; CHROMOSOME BANDING PATTERN; GENE TRANSLOCATION; GENETICS; HETEROZYGOSITY LOSS; MIDDLE AGED; ONCOGENE; REFRACTORY ANEMIA WITH EXCESS BLASTS; TUMOR SUPPRESSOR GENE;

AGED; AGED, 80 AND OVER; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; ANEUPLOIDY; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; FEMALE; GENE AMPLIFICATION; GENES, P53; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; ONCOGENES; SPECTRAL KARYOTYPING; TRANSLOCATION, GENETIC;

EID: 4644236053     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2003.12.014     Document Type: Article

References (31)

1. Mrózek K., Heinonen K., Theil K.S., Bloomfield C.D. Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. Genes Chromosomes Cancer. 34:2002;137-153
2. Romana S.P., Le Coniat M., Berger R. t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosomes Cancer. 9:1994;186-191
3. Martinez-Ramirez A., Urioste M., Contra T., Cantalejo A., Tavares A., Portero J.A., Lopez-Ibor B., Bernacer M., Soto C., Cigudosa J.C., Benitez J. Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia. Haematologica. 86:2001;1245-1253
4. Fenaux P., Morel P., Lai J.L. Cytogenetics of myelodysplastic syndromes. Semin Hematol. 33:1996;127-138
5. Greenberg P., Cox C., LeBeau M.M., Fenaux P., Morel P., Sanz G., Sanz M., Vallespi T., Hamblin T., Oscier D., Ohyashiki K., Toyama K., Aul C., Mufti G., Bennett J. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 89:1997;2079-2088
6. Schrock E., Padilla-Nash H. Spectral karyotyping and multicolor fluorescence in situ hybridization reveal new tumor-specific chromosomal aberrations. Semin Hematol. 37:2000;334-347
7. Veldman T., Vignon C., Schrock E., Rowley J.D., Ried T. Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. Nat Genet. 15:1997;406-410
8. Kakazu N., Taniwaki M., Horiike S., Nishida K., Tatekawa T., Nagai M., Takahashi T., Akaogi T., Inazawa J., Ohki M., Abe T. Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome. Genes Chromosomes Cancer. 26:1999;336-345
9. Mohr B., Bornhauser M., Thiede C., Schakel U., Schaich M., Illmer T., Pascheberg U., Ehninger G. Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. Leukemia. 14:2000;1031-1038
10. Lindvall C., Nordenskjold M., Porwit A., Bjorkholm M., Blennow E. Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements. Haematologica. 86:2001;1158-1164
11. Van Limbergen H., Poppe B., Michaux L., Herens C., Brown J., Noens L., Berneman Z., De Bock R., De Paepe A., Speleman F. Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer. 33:2002;60-72
12. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., Sultan C. Myelodysplastic syndromes: is another classification necessary? Br J Haematol. 56:1984;515-517
13. Mitelman F. ISCN guidelines for cancer cytogenetics. Supplement to an international system for human cytogenetic nomenclature. 1995;S. Karger, Basel
14. Martinez-Delgado B., Robledo M., Arranz E., Infantes F., Echezarreta G., Marcos B., Sanz C., Rivas C., Benitez J. Correlation between mutations in p53 gene and protein expression in human lymphomas. Am J Hematol. 55:1997;1-8
15. Agirre X., Vizmanos J.L., Calasanz M.J., Garcia-Delgado M., Larrayoz M.J., Novo F.J. Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients. Oncogene. 22:2003;1070-1072
16. Schoch C., Haferlach T., Haase D., Fonatsch C., Loffler H., Schlegelberger B., Staib P., Sauerland M.C., Heinecke A., Buchner T., Hiddemann W. Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients. Br J Haematol. 112:2001;118-126
17. Grimwade D., Walker H., Oliver F., Wheatley K., Harrison C., Harrison G., Rees J., Hann I., Stevens R., Burnett A., Goldstone A. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 92:1998;2322-2333
18. Schoch C., Haferlach T., Bursch S., Gerstner D., Schnittger S., Dugas M., Kern W., Loffler H., Hiddemann W. Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. Genes Chromosomes Cancer. 35:2002;20-29
19. Benitez J., Carbonell F., Sanchez Fayos J., Heimpel H. Karyotypic evolution in patients with myelodysplastic syndromes. Cancer Genet Cytogenet. 16:1985;157-167
20. Lai J.L., Zandecki M., Fenaux P., Le Baron F., Bauters F., Cosson A., Deminatti M. Translocations (5;17) and (7;17) in patients with de novo or therapy- related myelodysplastic syndromes or acute nonlymphocytic leukemia. A possible association with acquired pseudo-Pelger-Huet anomaly and small vacuolated granulocytes. Cancer Genet Cytogenet. 46:1990;173-183
21. Lai J.L., Preudhomme C., Zandecki M., Flactif M., Vanrumbeke M., Lepelley P., Wattel E., Fenaux P. Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoiesis and a high incidence of P53 mutations. Leukemia. 9:1995;370-381
22. Soenen V., Preudhomme C., Roumier C., Daudignon A., Lai J.L., Fenaux P. 17p deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ. Blood. 91:1998;1008-1015
23. Sterkers Y., Preudhomme C., Lai J.L., Demory J.L., Caulier M.T., Wattel E., Bordessoule D., Bauters F., Fenaux P. Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea: high proportion of cases with 17p deletion. Blood. 91:1998;616-622
24. Martin-Subero J.I., Harder L., Gesk S., Schoch R., Novo F.J., Grote W., Calasanz M.J., Schlegelberger B., Siebert R. Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia. Cancer Genet Cytogenet. 127:2001;174-176
25. Cuthbert G., Thompson K., McCullough S., Watmore A., Dickinson H., Telford N., Mugneret F., Harrison C., Griffiths M., Bown N. MLL amplification in acute leukaemia: a UK Cancer Cytogenetics Group (UKCCG) study. Leukemia. 14:2000;1885-1891
26. Michaux L., Wlodarska I., Stul M., Dierlamm J., Mugneret F., Herens C., Beverloo B., Verhest A., Verellen-Dumoulin C., Verhoef G., Selleslag D., Madoe V., Lecomte M., Deprijck B., Ferrant A., Delannoy A., Marichal S., Duhem C., Dicato M., Hagemeijer A. MLL amplification in myeloid leukemias: a study of 14 cases with multiple copies of 11q23. Genes Chromosomes Cancer. 29:2000;40-47
27. Streubel B., Valent P., Jager U., Edelhauser M., Wandt H., Wagner T., Buchner T., Lechner K., Fonatsch C. Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. Genes Chromosomes Cancer. 27:2000;380-386
28. Hilgenfeld E., Padilla-Nash H., McNeil N., Knutsen T., Montagna C., Tchinda J., Horst J., Ludwig W.D., Serve H., Buchner T., Berdel W.E., Schrock E., Ried T. Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2. Br J Haematol. 113:2001;305-317
29. Roumier C., Fenaux P., Lafage M., Imbert M., Eclache V., Preudhomme C. New mechanisms of AML1 gene alteration in hematological malignancies. Leukemia. 17:2003;9-16
30. Castro P.D., Liang J.C., Nagarajan L. Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms. Blood. 95:2000;2138-2143
31. Christiansen D.H., Andersen M.K., Pedersen-Bjergaard J. Mutations with loss of heterozygosity of p53 are common in therapy- related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q a complex karyotype and a poor prognosis. J Clin Oncol. 19:2001;1405-1413