A new method using flow cytometry to measure the effects of drugs on gastric emptying and gastrointestinal transit in mice

Arzneimittel-Forschung/Drug Research

Volumn 54, Issue 9, 2004, Pages 557-562

  Inada, Takefumi ^a   Asai, Takashi ^a   Yamada, Makiko ^a   Shingu, Koh ^a  

^a KANSAI MEDICAL UNIVERSITY HOSPITAL   (Japan)

Author keywords

CAS 113775 47 6; CAS 52 26 6; Dexmedetomidine; Flow cytometry; Gastric emptying, effect of drugs; Gastrointestinal transit, effect of drugs; Morphine

Indexed keywords

DEXMEDETOMIDINE; FLUORESCENT DYE; MORPHINE; POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVICE; DOSE RESPONSE; FLOW CYTOMETER; FLOW CYTOMETRY; GASTROINTESTINAL TRANSIT; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; ISOTOPE LABELING; LABORATORY APPARATUS, EQUIPMENT AND SUPPLIES; MALE; MOUSE; NONHUMAN; RAT; STOMACH EMPTYING;

EID: 4644231750     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1297012     Document Type: Article

References (20)

1. Barquist, E., Zinner, M., Rivier, J. et al., Abdominal surgery-induced delayed gastric emptying in rats: role of CRF and sensory neurons. Am. J. Physiol. 262, G616 (1992)
2. Scarpignato, C., Bertaccini, G., Bombesin delays gastric emptying in the rat. Digestion 21, 104 (1981)
3. Mashimo, H., Kjellin, A., Goyal, R. K., Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. Gastroenterology 119, 766 (2000)
4. Donaldson, R. M, Jr., Barreras, R. F., Intestinal absorption of trace quantities of chromium. J. Lab. Clin. Med. 68, 484 (1966)
5. Miller, M. S., Galligan, J. J., Burks, T. F., Accurate measurement of intestinal transit in the rat. J. Pharmacol. Methods 6, 211 (1981)
6. Asai, T., Mapleson, W. W., Power, I., Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br. J. Anaesth. 78, 301 (1997)
7. Asai, T., Mapleson, W. W., Power, I., Interactive effect of morphine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br. J. Anaesth. 80, 63 (1998)
8. Asai, T., Mapleson, W. W., Power, I., Effects of nalbuphine, pentazocine and U50488H on gastric emptying and gastrointestinal transit in the rat. Br. J. Anaesth. 80, 814 (1998)
9. Asai, T., Power, I., Naloxone inhibits gastric emptying in the rat. Anesth. Analg. 88, 204 (1999)
10. Rosenblum, B. B., Lee, L. G., Spurgeon, S. L. et al., New dye-labelled terminators for improved DNA sequencing patterns. Nucleic Acids Res. 25, 4500 (1997)
11. Brown, J. M., Evans, J., Kovacs, M. S., The prediction of human tumor radiosensitivity in situ: an approach using chromosome aberrations detected by fluorescence in situ hybridization. Int. J. Radiat. Oncol. Biol. Phys. 24, 279 (1992)
12. Yeung, C.-K., McCurrie, J. R., Wood, D., A simple method to investigate the inhibitory effects of drugs on gastric emptying in the mouse in vivo. J. Pharmacol. Toxicol. Methods 45, 235 (2001)
13. Russell, B. Yaksh, T. L., Antagonism by phenoxybenzamine and pentazocine of the antinociceptive effects of morphine in the spinal cord. Neuropharmacology. 20, 575 (1981)
14. Savola, J.-M., Virtanen, R., Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur. J. Pharmacol. 195, 193 (1991)
15. Owen, R. L., Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructual study. Gastroenterology. 72, 440 (1977)
16. Sass, W., Dreyer, H.-P., Seifert, J., Rapid insorption of small particles in the gut. Am. J. Gastroenterol. 85, 255 (1990)
17. Scheufler, E., Zetler, G., Interactions of caerulein and morphine on gastrointestinal propulsion in the mouse. Naunyn-Schmiedebergs Arch. Pharmacol. 318, 66 (1981)
18. Wong, C. L., Central and peripheral inhibitory effects of morphine on intestinal transit in mice. Methods Find. Exp. Clin. Pharmacol. 8, 479 (1986)
19. Bianchi, G., Ferretti, P., Recchia, M. et al., Morphine tissue levels and reduction of gastrointestinal transit in rats. Correlation supports primary action site in the gut. Gastroenterology 85, 852 (1983)
20. Rowbotham, D. J., Nimmo, W. S., Effect of cisapride on morphine-induced delay in gastric emptying. Br. J. Anaesth. 59, 536 (1987)