Orexin-2 receptors inhibit primary afferent fiber-evoked responses of ventral roots in the neonatal rat isolated spinal cord

Brain Research

Volumn 1218, Issue , 2008, Pages 97-102

  Shono, Koyo ^a   Yamamoto, Tatsuo ^b  

^a CHIBA UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Neonatal spinal cord; Orexin; Rat; Slow ventral root potential; Wind up

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; DORSAL ROOT; EVOKED RESPONSE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL CORD; SYNAPTIC POTENTIAL; VENTRAL ROOT;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BENZOXAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EVOKED POTENTIALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE FIBERS; NEURAL INHIBITION; NEURONS, AFFERENT; NEUROPEPTIDES; PROTEIN BINDING; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SPINAL CORD; SPINAL NERVE ROOTS; UREA;

RATTUS;

EID: 46349103258     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.04.016     Document Type: Article

References (26)

1. Akagi H., Konishi S., Otsuka M., and Yanagisawa M. The role of substance P as a neurotransmitter in the reflexes of slow time courses in the neonatal rat spinal cord. Br. J. Pharmacol. 84 (1985) 663-673
2. 15]orexin-B. Bioorg. Med. Chem. Lett. 13 (2003) 111-113
3. Asghar A.U.R., Hasan S.S., and King A.E. Actions of the anticonvulsant remacemide metabolite AR-R12495AA on afferent-evoked spinal synaptic transmission in vitro and on models of acute and chronic inflammation in the rat. J. Pharmacol. Exp. Ther. 294 (2000) 876-883
4. Bingham S., Davey P.T., Babbs A.J., Irving E.A., Sammons M.J., Wyles A.J., and Parsons A.A. Orexin-A, an hypothalamic peptide with analgesic properties. Pain 92 (2001) 81-90
5. Grudt T.J., van den Pol A.N., and Perl E.R. Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J. Physiol. 538 (2002) 517-525
6. Hagan J.J., Leslie R.A., Patel S., Evans M.L., Wattam T.A., Holmes S., Benham C.D., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., Shah A.S., Hatcher J.P., Hatcher P.D., Jones D.N., Smith M.I., Piper D.C., Hunter A.J., Porter R.A., and Upton N. Orexin-A activates locus coeruleus cell firing and increases arousal in the rat. Proc., Nat., Acad., Sci., 1999. 96 (1999) 10911-10916
7. Hathway G., Harrop E., Baccei M., Walker S., Moss A., and Fitzgerald M. A postnatal switch in GABAergic control of spinal cutaneous reflexes. Eur. J. Neurosci. 23 (2006) 112-118
8. Hirota K., Kushikata T., Kudo M., Kudo T., Smart D., and Matsuki A. Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats. Brain Res. 981 (2003) 143-150
9. Holland P.R., Akerman S., and Goadsby P.J. Modulation of nociceptive dural input to the trigeminal nucleus caudalin via activation of the orexin 1 receptor in the rat. Eur. J. Neurosci. 24 (2006) 2825-2833
10. Kajiyama S., Kawamoto M., Shiraishi S., Gaus S., Matsunaga A., Suyama H., and Yuge O. Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathy pain model rats. Brain Res. 1044 (2005) 76-86
11. Lubkin M., and Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem. Biophys. Res. Commun. 253 (1998) 241-245
12. Otsuka M., and Konishi S. Electrophysiology of mammalian spinal cord in vitro. Nature 252 (1974) 733-734
13. Otsuka M., and Yanagisawa M. Effect of a tachykinin antagonist on a nociceptive reflex in the isolated spinal cord-tail preparation of the newborn rat. J. Physiol. 395 (1988) 255-270
14. Porter R.A., Chan W.N., Coulton S., Johns A., Hadley M.S., Widdowson K., Jerman J.C., Brough S.J., Coldwell M., Smart D., Jewitt F., Jeffrey P., and Austin N. 1,3-biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg. Med. Chem. Lett. 11 (2001) 1907-1910
15. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexin and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
16. Smart D., Sabido-David C., Brough S.J., Jewitt F., Johns A., Porter R.A., and Jerman J.C. SB-334867-A: the first selective orexin-1 receptor antagonist. Br. J. Pharmacol. 132 (2001) 1179-1182
17. Schwartz M.W. Orexins and appetite: the big picture of energy homeostasis gets a little bigger. Nat. Med. 4 (1998) 385-386
18. Thompson S.W.N., Dray A., and Urban L. Injury-induced plasticity of spinal reflex activity. NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. J. Neurosci. 14 (1994) 3672-3687
19. Woodley S.J., and Kendig J.J. Substance P and NMDA receptors mediate a slow nociceptive ventral root potential in neonatal rat spinal cord. Brain Res. 559 (1991) 17-21
20. Yamamoto T., and Yaksh T.L. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 77 (1992) 757-763
21. Yamamoto T., and Yaksh T.L. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain 49 (1992) 121-128
22. Yamamoto T., Nozaki-Taguchi N., and Chiba T. Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test. Br. J. Pharmacol. 137 (2002) 170-176
23. Yamamoto T., Saito O., Shono K., and Hirasawa S. Activation of spinal orexin-1 receptor produces anti-allodynic effect in the rat carrageenan test. Eur. J. Pharmacol. 481 (2003) 175-180
24. Yamamoto T., Saito O., Shono K., Aoe T., and Chiba T. Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model. Neurosci. Lett. 347 (2003) 183-186
25. Yanagisawa M., Murakoshi T., Tamai S., and Otsuka M. Tail-pinch method in vitro and the effects of some antinociceptive compounds. Eur. J. Pharmacol. 106 (1984) 231-239
26. Zhang J.-H., Sampogna S., Morales R.F., and Chase M.H. Age-related ultrastructural changes of hypocretinergic terminals in brain stem and spinal cord of cats. Neurosci. Lett. 373 (2005) 171-174