Molecular epidemiology of candidemia: Evidence of clusters of smoldering nosocomial infections

Clinical Infectious Diseases

Volumn 47, Issue 2, 2008, Pages

  Ásmundsdóttir, Lena Rós ^a   Erlendsdóttir, Helga ^b   Haraldsson, Gunnsteinn ^a,b   Guo, Hong ^c   Xu, Jianping ^c   Gottfredsson, Magnús ^a,b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANDIDA ALBICANS; CANDIDA DUBLINIENSIS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CANDIDEMIA; CHILD; CLONE; FATALITY; FEMALE; FUNGAL STRAIN; FUNGUS ISOLATION; GENOTYPE; HOSPITAL INFECTION; HUMAN; INFECTION RISK; MALE; MOLECULAR EPIDEMIOLOGY; NEWBORN INTENSIVE CARE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WARD;

ADULT; CANDIDA; CANDIDIASIS; CHILD; CLUSTER ANALYSIS; CROSS INFECTION; DISEASE OUTBREAKS; DNA FINGERPRINTING; DNA PRIMERS; DNA, FUNGAL; EPIDEMIOLOGY, MOLECULAR; FEMALE; FUNGEMIA; GENOTYPE; HUMANS; ICELAND; INCIDENCE; INFANT, NEWBORN; INTENSIVE CARE UNITS; INTENSIVE CARE UNITS, NEONATAL; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; RETROSPECTIVE STUDIES;

EID: 46349088344     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/589298     Document Type: Article

References (35)

1. Pfaller MA, Diekema DJ, Jones RN, et al. International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J Clin Microbiol 2001; 39:3254-9.
2. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-54.
3. Banerjee SN, Emori TG, Culver DH, et al. Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989. National Nosocomial Infections Surveillance System. Am J Med 1991; 91:86S-9S.
4. Rentz AM, Halpern MT, Bowden R. The impact of candidemia on length of hospital stay, outcome, and overall cost of illness. Clin Infect Dis 1998; 27:781-8.
5. Gudlaugsson O, Gillespie S, Lee K, et al. Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis 2003; 37:1172-7.
6. Ásmundsdóttir LR, Erlendsdóttir H, Gottfredsson M. Improving survival of patients with candidaemia: analysis of prognostic factors from a long-term, nationwide study in Iceland. Scand J Infect Dis 2005; 37:111-20.
7. Ásmundsdóttir LR, Erlendsdóttir H, Gottfredsson M. Increasing incidence of candidemia: results from a 20-year nationwide study in Iceland. J Clin Microbiol 2002; 40:3489-92.
8. Marco F, Lockhart SR, Pfaller MA, et al. Elucidating the origins of nosocomial infections with Candida albicans by DNA fingerprinting with the complex probe Ca3. J Clin Microbiol 1999; 37:2817-28.
9. Sanchez V, Vazquez JA, Barth-Jones D, Dembry L, Sobel JD, Zervos MJ. Nosocomial acquisition of Candida parapsilosis: an epidemiologic study. Am J Med 1993; 94:577-82.
10. Pfaller MA. Epidemiology of candidiasis. J Hosp Infect 1995; 30(Suppl):329-38.
11. Pfaller MA. Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission. Clin Infect Dis 1996; 22(Suppl 2):S89-94.
12. Ruiz-Diez B, Martinez V, Alvarez M, Rodriguez-Tudela JL, Martinez-Suarez JV. Molecular tracking of Candida albicans in a neonatal intensive care unit: long-term colonizations versus catheter-related infections. J Clin Microbiol 1997; 35:3032-6.
13. Soll DR. The ins and outs of DNA fingerprinting the infectious fungi. Clin Microbiol Rev 2000; 13:332-70.
14. Gottfredsson M, Cox GM, Perfect JR. Molecular methods for epidemiological and diagnostic studies of fungal infections. Pathology 1998; 30:405-18.
15. Thanos M, Schonian G, Meyer W, et al. Rapid identification of Candida species by DNA fingerprinting with PCR. J Clin Microbiol 1996; 34:615-21.
16. Xu J, Ramos AR, Vilgalys R, Mitchell TG. Clonal and spontaneous origins of fluconazole resistance in Candida albicans. J Clin Microbiol 2000; 38:1214-20.
17. Robles JC, Koreen L, Park S, Perlin DS. Multilocus sequence typing is a reliable alternative method to DNA fingerprinting for discriminating among strains of Candida albicans. J Clin Microbiol 2004; 42:2480-8.
18. Pujol C, Joly S, Lockhart SR, Noel S, Tibayrenc M, Soll DR. Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida albicans. J Clin Microbiol 1997; 35:2348-58.
19. Viviani MA, Cogliati M, Esposto MC, Prigitano A, Tortorano AM. Four-year persistence of a single Candida albicans genotype causing blood-stream infections in a surgical ward proven by multilocus sequence typing. J Clin Microbiol 2006; 44:218-21.
20. Gottfredsson M, Vredenburgh JJ, Xu J, SchellWA, Perfect JR. Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation. Cancer 2003; 98:24-30.
21. Clark TA, Slavinski SA, Morgan J, et al. Epidemiologic and molecular characterization of an outbreak of Candida parapsilosis bloodstream infections in a community hospital. J Clin Microbiol 2004; 42:4468-72.
22. Chowdhary A, Becker K, Fegeler W, et al. An outbreak of candidemia due to Candida tropicalis in a neonatal intensive care unit. Mycoses 2003; 46:287-92.
23. Sandven P, Bevanger L, Digranes A, Gaustad P, Haukland HH, Steinbakk M. Constant low rate of fungemia in Norway, 1991 to 1996. The Norwegian Yeast Study Group. J Clin Microbiol 1998; 36:3455-9.
24. Daneman N, Green KA, Low DE, et al. Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000. Ann Intern Med 2007; 147:234-41.
25. Reagan DR, Pfaller MA, Hollis RJ, Wenzel RP. Evidence of nosocomial spread of Candida albicans causing bloodstream infection in a neonatal intensive care unit. Diagn Microbiol Infect Dis 1995; 21:191-4.
26. Gastmeier P, Groneberg K, Weist K, Ruden H. A cluster of nosocomial Klebsiella pneumoniae bloodstream infections in a neonatal intensive care department: identification of transmission and intervention. Am J Infect Control 2003; 31:424-30.
27. Lin YC, Lauderdale TL, Lin HM, et al. An outbreak of methicillin- resistant Staphylococcus aureus infection in patients of a pediatric intensive care unit and high carriage rate among health care workers. J Microbiol Immunol Infect 2007; 40:325-34.
28. Hanna H, Umphrey J, Tarrand J, Mendoza M, Raad I. Management of an outbreak of vancomycin-resistant enterococci in the medical intensive care unit of a cancer center. Infect Control Hosp Epidemiol 2001; 22:217-9.
29. Pfaller MA, Lockhart SR, Pujol C, et al. Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates. J Clin Microbiol 1998; 36:1518-29.
30. van Asbeck EC, Huang YC, Markham AN, Clemons KV, Stevens DA. Candida parapsilosis fungemia in neonates: genotyping results suggest healthcare workers hands as source, and review of published studies. Mycopathologia 2007; 164:287-93.
31. Finkelstein R, Reinhertz G, Hashman N, Merzbach D. Outbreak of Candida tropicalis fungemia in a neonatal intensive care unit. Infect Control Hosp Epidemiol 1993; 14:587-90.
32. Strausbaugh LJ, Sewell DL, Ward TT, Pfaller MA, Heitzman T, Tjoelker R. High frequency of yeast carriage on hands of hospital personnel. J Clin Microbiol 1994; 32:2299-300.
33. Zaoutis TE, Argon J, Chu J, Berlin JA, Walsh TJ, Feudtner C. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis 2005; 41:1232-9.
34. Smith PB, Morgan J, Benjamin JD, et al. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J 2007; 26:197-200.
35. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006; 355:2725-32.