Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humans

Heart Rhythm

Volumn 5, Issue 7, 2008, Pages 1003-1008

  Sandhu, Roopinder K ^a   Costantini, Ottorino ^a   Cummings, Jennifer E ^a   Poelzing, Steve ^a   Rosenbaum, David S ^a   Quan, Kara J ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cardiomyopathy; Human; Intracardiac; Repolarization; T wave alternans

Indexed keywords

ADULT; AGED; ALGORITHM; ARTICLE; CARDIOMYOPATHY; CATHETER; DEFIBRILLATOR; ELECTROCARDIOGRAM; ELECTROGRAPHY; FEMALE; FOLLOW UP; HEART ATRIUM PACING; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART PALPITATION; HEART REPOLARIZATION; HEART RIGHT VENTRICLE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIMARY PREVENTION; PRIORITY JOURNAL; SYNCOPE; T WAVE;

ADULT; AGED; BODY SURFACE POTENTIAL MAPPING; CARDIAC ELECTROPHYSIOLOGY; CARDIAC PACING, ARTIFICIAL; CARDIOMYOPATHIES; DEATH, SUDDEN, CARDIAC; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; STROKE VOLUME; TACHYCARDIA, VENTRICULAR;

EID: 46349083675     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2008.04.003     Document Type: Article

References (23)

1. Zheng Z.J., Croft J.B., Giles W.H., and Mensah G.A. Deaths: leading causes for 2002. Natl Vital Stat Rep (2005) 531-589
2. Myerburg R.J., Kessler K.M., and Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med 119 (1993) 1187-1197
3. Kannel W.B., and Schatzkin A. Sudden death: lessons from subsets in population studies. J Am Coll Cardiol 5 suppl (1985) 141B-149B
4. Rosenbaum D.S., Jackson L.E., Smith J.M., et al. Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 330 (1994) 235-241
5. Hohnloser S.H. Macroscopic T-wave alternans as a harbinger of sudden cardiac death. J Cardiovasc Electrophysiol 10 (1999) 625
6. Klingenheben T., Zabel M., D'Agostino R.B., Cohen R.J., and Hohnloser S.H. Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. Lancet 356 (2000) 651-652
7. Rosenbaum D.S., Albrecht P., and Cohen R. Predicting sudden cardiac death from T-wave alternans of the surface electrocardiogram: promise and pitfalls. J Cardiovasc Electrophysiol 7 (1996) 1095-1111
8. Bloomfield D.M., Steinman R.C., Namerow P.B., et al. Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit form implanted cardiac defibrillator therapy; a solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum. Circulation 110 (2004) 1885-1889
9. Costantini O., Kaufman E.S., Bloomfield D.M., et al. Patients with a nonischemic cardiomyopathy and a negative T-wave alternans stress test are at a low risk of death. Circulation 110 (2004) 1885-1889
10. Bloomfield D.M., Bigger J.T., Steinmann R.C., et al. Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol 47 (2006) 456-463
11. Pastore J.M., and Rosenbaum D.S. Role of structural barriers in the mechanism of alternans-induced reentry. Circ Res 87 (2000) 1157-1163
12. Pastore J.M., Girouard S.D., Laurita K.R., Akar F.G., and Rosenbaum D.S. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99 (1999) 1385-1394
13. Paz O., Zhou X., Gillberg J., et al. Detection of T-wave alternans using an implantable cardioverter-defibrillator. Heart Rhythm 3 (2006) 791-797
14. Selvaraj R.J., Picton P., Nanthakumar K., Mak S., and Chauhan V. Endocardial and epicardial repolarization alternans in human cardiomyopathy: evidence for spatiotemporal heterogeneity and correlation with body surface T-wave alternans. J Am Coll Cardiol 49 (2007) 338-346
15. Christini D.J., Stein K.M., Hao S.C., et al. Endocardial detection of repolarization alternans. IEEE 50 (2003) 855-860
16. Armoundas A.A., Albert C.M., Cohen R.J., et al. Utility of implantable cardioverter defibrillator electrograms to estimate repolarization alternans preceding a tachyarrhythmic event. J Cardiovasc Electrophysiol 15 (2004) 594-597
17. Maybhate A., Hao S.C., Iwai S., et al. Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model. IEEE Trans Biomed Eng 52 (2005) 1188-1194
18. Bloomfield D.M., Hohnloser S.H., and Cohen R.J. Interpretation and classification of microvolt T wave alternans tests. J Cardiovasc Electrophysiol 16 (2002) 502-512
19. Rosenbaum D.S. Analysis of the T-wave in assessing cardiac risk. Cardiol Rev 5 (1997) 152-160
20. Pruvot E.J., Katra R.P., Rosenbaum D.S., and Laurita K.R. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ Res 94 (2004) 1083-1090
21. Bouchard R.A., Clark R.B., and Files W.R. Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes; action potential voltage-clamp measurements. Circ Res 76 (1995) 790-801
22. Armoundas A.A., Hohnloser S.H., Ikeda T., et al. Can microvolt T-wave alternans testing reduce unnecessary defibrillator implantation?. Nat Clin Pract Cardiovasc Med 2 (2005) 522-528
23. MERIT-HF Investigators. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 353 (1999) 2001-2007