Treatment with granulocyte colony stimulating factor is associated with improvement in endothelial function

Growth Factors

Volumn 26, Issue 3, 2008, Pages 117-124

  Ikonomidis, Ignatios ^a   Papadimitriou, Christos ^a   Vamvakou, Georgia ^a   Katsichti, Paraskevi ^a   Venetsanou, Kiriaki ^a   Stamatelopoulos, Kimon ^a   Papamichael, Christos ^a   Dimopoulos, Athanasios Meletios ^a   Lekakis, John ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

CRP; Endothelium; Granulocyte colony stimulating factor; Interleukins

Indexed keywords

C REACTIVE PROTEIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; GLYCERYL TRINITRATE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADJUVANT THERAPY; ADULT; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BRACHIAL ARTERY; BREAST CANCER; CANCER ADJUVANT THERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

AGED; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; C-REACTIVE PROTEIN; CYTOKINES; ENDOTHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-10; MIDDLE AGED; MODELS, BIOLOGICAL; PLACEBOS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 46249116428     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190802090614     Document Type: Article

References (38)

1. Adamopoulos, S. Parissis, JT et al. (2003) Effects of growth hormone on circulating cytokine network and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathy. Eur Heart J, 24:24, pp. 2186-2196.
2. Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C., Technau-Ihling, K., Zeiher, AM and Dimmeler, S. (2003) Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med, 9, pp. 1370-1376.
3. Anderlini, P., Przepiorka, D., Champlin, R. and Körbling, M. (1996) Biologic and clinical effects of granulocyte colony stimulating factor in normal individuals. Blood, 88, pp. 2819-2825.
4. Baum, M. and Ravdin, PM (2002) Decision-making in early breast cancer: Guidelines and decision tools. Eur J Cancer, 38, pp. 745-749.
5. Benoy, I., Salgado, R., Colpaert, C., Weytjens, R., Vermeulen, PB and Dirix, LY (2002) Serum interleukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients. Clin Breast Cancer, 2, pp. 311-315.
6. Bhattacharya, V., Shi, Q., Atsushi, I., Sauvage, LR and Hammond, WP (2000) Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts. J Vasc Surg, 32, pp. 116-123.
7. Bruunsgaard, H. (2002) Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations. Eur Cytokine Netw, 13, pp. 389-391.
8. Carstanjen, D., Regenfus, M., Muller, C. and Salama, A. (2001) Interleukin-6 is a major effector molecule of short-term G-CSF treatment by inducing bone metabolism and an acute-phase response. Exp Hematol, 29, pp. 812-821.
9. Cho, HJ, Kim, HS, Lee, MM, Kim, DH, Yang, HJ, Hur, J., Hwang, KK, Oh, S., Choi, YJ, Chae, IH, Oh, BH, Choi, YS, Walsh, K. and Park, YB (2003) Mobilized endothelial progenitor cells by granulocyte-macrophage colony-stimulating factor accelerate reendothelialization and reduce vascular inflammation after intravascular radiation. Circulation, 108, pp. 2918-2925.
10. de Muinck, ED and Simons, M. (2005) Calling on reserves: Granulocyte colony stimulating growth factor in cardiac repair. Circulation, 112, pp. 3033-3035.
11. Dupont, WD and Plummer, WD (1990) 'Power and sample size calculations: A review and computer program. Control Clin Trials, 11, pp. 116-128.
12. Duquaine, D., Hirsch, GA, Chakrabarti, A., Han, Z., Kehrer, C., Brook, R., Joseph, J., Schott, A., Kalyanaraman, B., Vasquez-Vivar, J. and Rajagopalan, S. (2003) Rapid-onset endothelial dysfunction with adriamycin: Evidence for a dysfunctional nitric oxide synthase. Vasc Med, 8, pp. 101-107.
13. Eissner, G., Lindner, H., Reisbach, G., Klauke, I. and Holler, E. (1997) Differential modulation of IL-1 induced endothelial adhesion molecules and transendothelial migration of granulocytes by G-CSF. Br J Haematol, 97, pp. 726-733.
14. Fichtlscherer, S., Breuer, S., Heeschen, C., Dimmeler, S. and Zeiher, AM (2004) Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease. J Am Coll Cardiol, 44, pp. 44-49.
15. Gunnett, CA, Heistad, DD and Faraci, FM (2002) Interleukin-10 protects nitric oxide-dependent relaxation during diabetes: Role of superoxide. Diabetes, 51, pp. 1931-1937.
16. Harada, M., Qin, Y., Takano, H., Minamino, T., Zou, Y., Toko, H., Ohtsuka, M., Matsuura, K., Sano, M., Nishi, J., Iwanaga, K., Akazawa, H., Kunieda, T., Zhu, W., Hasegawa, H., Kunisada, K., Nagai, T., Nakaya, H., Yamauchi-Takihara, K. and Komuro, I. (2005) G-CSF prevents cardiac remodelling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med, 11, pp. 305-311.
17. Hartung, T., Docke, WD, Gantner, F., Krieger, G., Sauer, A., Stevens, P., Volk, HD and Wendel, A. (1995) Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood, 85, pp. 2482-2489.
18. Hill, JM, Zalos, G., Halcox, JP, Schenke, WH, Waclawiw, MA, Quyyumi, AA and Finkel, T. (2003) Circulating endothelial progenitor cells, vascular function and cardiovascular risk. N Engl J Med, 348, pp. 593-600.
19. Hill, JM, Syed, MA, Arai, AE, Powell, TM, Paul, JD, Zalos, G., Read, EJ, Khuu, HM, Leitman, SF, Horne, M., Csako, G., Dunbar, CE, Waclawiw, MA and Cannon 3rd, RO (2005) Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease. J Am Coll Cardiol, 46, pp. 1643-1648.
20. Ikonomidis, I., Athanassopoulos, G., Lekakis, J., Venetsanou, K., Marinou, M., Stamatelopoulos, K., Cokkinos, DV and Nihoyannopoulos, P. (2005) Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: A dobutamine stress echocardiography study. Circulation, 112, pp. 3272-3279.
21. Ince, H., Petzsch, M., Kleine, HD, Schmidt, H., Rehders, T., Korber, T., Schumichen, C., Freund, M. and Nienaber, CA (2005) Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation, 112, pp. 3033-3035.
22. Iversen, PO, Nicolaysen, A., Kvernebo, K., Benestad, HB and Nicolaysen, G. (1999) Human cytokines modulate arterial vascular tone via endothelial receptors. Pflugers Arch-Eur J Physiol, 439, pp. 93-100.
23. Joseph, J., Rimawi, A., Mehta, P., Cottler-Fox, M., Sinha, A., Singh, BK, Pacheco, R., Smith 3rd, ES and Mehta, JL (2006) Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure. Am J Cardiol, 97, pp. 681-684.
24. Kang, HJ, Kim, HS, Zhang, SY, Park, KW, Cho, HJ, Koo, BK, Kim, YJ, Soo Lee, D, Sohn, DW, Han, KS, Oh, BH, Lee, MM and Park, YB (2004) Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: The MAGIC cell randomised clinical trial. Lancet, 363, pp. 751-756.
25. Lee, M., Aoki, M., Kondo, T., Kobayashi, K., Okumura, K., Komori, K. and Murohara, T. (2005) Therapeutic angiogenesis with intramuscular injection of low-dose recombinant granulocyte-colony stimulating factor. Arterioscler Thromb Vasc Biol, 25, pp. 2535-2541.
26. Lekakis, JP, Ikonomidis, I., Tsibida, M., Protogerou, A., Papada, A., Papapanagiotou, A., Revela, I., Papamichael, CM, Kalofoutis, AT and Kremastinos, DT (2006) Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease. Thromb Haemost, 96, pp. 520-528.
27. Lenk, K., Adams, V., Lurz, P., Erbs, S., Linke, A., Gielen, S., Schmidt, A., Scheinert, D., Biamino, G., Emmrich, F., Schuler, G. and Hambrecht, R. (2005) Therapeutical potential of blood progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischemia. Eur Heart J, 26, pp. 1903-1909.
28. Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, DM, Leri, A. and Anversa, P. (2001) Mobilized bone marrow cells repair the infracted heart, improving function and survival. Proc Natl Acad Sci U S A, 98, pp. 10344-10349.
29. Ozuyaman, B., Ebner, P., Niesler, U., Ziemann, J., Kleinbongard, P., Jax, T., Godecke, A., Kelm, M. and Kalka, C. (2005) Nitric oxide differentially regulates proliferation and mobilization of endothelial progenitor cells but not of hematopoietic stem cells. Thromb Haemost, 94, pp. 770-772.
30. Piccart, MJ, van de Velde, C. and Straehle, C. (2000) The EORTC strategy for the early 2000's. Clin Breast Cancer, 1, pp. 166-167.
31. Raitakari, OT and Celermajer, DS (2000) Flow-mediated dilatation. Br J Clin Pharmacol, 50:5, pp. 397-404.
32. Sesti, C., Hale, SL, Lutzko, C. and Kloner, RA (2005) Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infracted left ventricle independent of restoring muscle mass. J Am Coll Cardiol, 46, pp. 1662-1669.
33. Spuck, S., Schaaf, B., Wiedorn, KH, Hansen, F., Vollmer, E., Dalhoff, K. and Braun, J. (2003) G-CSF application in patients with severe bacterial pneumonia increases IL-10 expression in neutrophils. Respir Med, 97, pp. 51-58.
34. Stamatelopoulos, KS, Lekakis, JP, Poulakaki, NA, Papamichael, CM, Venetsanou, K., Aznaouridis, K., Protogerou, AD, Papaioannou, TG, Kumar, S. and Stamatelopoulos, SF (2004) Tamoxifen improves endothelial function and reduces carotid intima-media thickness in postmenopausal women. Am Heart J, 147, pp. 1093-1099.
35. Tedgui, A. and Mallat, Z. (2001) Anti-inflammatory mechanisms in the vascular wall. Circ Res, 88, pp. 877-887.
36. Wæhre, T., Halvorsen, B., Damås, JK, Yndestad, A., Brosstad, F., Gullestad, L., Kjekshus, J., Frøland, SS and Aukrust, P. (2002) Inflammatory imbalance between IL-10 and TNF-α in unstable angina potential plaque stabilizing effects of IL-10. Eur J of Clin Invest, 32, pp. 803-810.
37. Xu, S., Hoglund, M. and Hakansson, L. (2000) Granulocyte colony stimulating factor-G-CSF induces production of cytokines in vivo. Br J Haematol, 108, pp. 848-853.
38. Yong, KL (1996) Granulocyte colony stimulating factor-G-CSF increases neutrophil migration across vascular endothelium independent of an effect of adhesion: Comparison with granulocyte-macrophage colony stimulating factor-GM-CSF. Br J Haematol, 94, pp. 40-47.