In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI

British Journal of Pharmacology

Volumn 154, Issue 5, 2008, Pages 1063-1072

  Karmouty Quintana, H ^a,b,c   Ble F X ^a,d   Cannet, C ^a   Zurbruegg, S ^a   Fozard, J R ^a   Page, C P ^b   Beckmann, N ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Capsazepine; Cromoglycate; Imaging; Leukotriene; Lung; Magnetic resonance imaging (MRI); PI3 kinase; Prostaglandin; Rat; Wortmannin

Indexed keywords

2 (3,4 DIHYDRO 3,4 DIOXO 1 NAPHTHYLAMINO)BENZOIC ACID METHYL ESTER; BUDESONIDE; CAPSAZEPINE; COMPOUND 48-80; CROMOGLYCATE DISODIUM; DNK 333; INDOMETACIN; TACHYKININ RECEPTOR ANTAGONIST; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG RESPONSE; HISTOPATHOLOGY; IN VIVO STUDY; INFLAMMATORY CELL; LUNG EDEMA; LUNG FLUID; LUNG LAVAGE; MALE; MAST CELL DEGRANULATION; NERVE CONDUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SENSORY NERVE; SIGNAL TRANSDUCTION;

ANDROSTADIENES; ANIMALS; ANTHRANILIC ACIDS; ANTI-INFLAMMATORY AGENTS; AZA COMPOUNDS; BENZAMIDES; BRONCHOALVEOLAR LAVAGE FLUID; BUDESONIDE; CAPSAICIN; CELL DEGRANULATION; CROMOLYN SODIUM; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; INDOMETHACIN; LUNG; MAGNETIC RESONANCE IMAGING; MALE; MAST CELLS; NAPHTHOQUINONES; P-METHOXY-N-METHYLPHENETHYLAMINE; PROTEINS; PULMONARY EDEMA; RATS; RATS, INBRED BN; RESPIRATORY SYSTEM AGENTS; TIME FACTORS;

EID: 46249111868     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.174     Document Type: Article

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