Microemboli detection and classification by innovative ultrasound technology during simulated neonatal cardiopulmonary bypass at different flow rates, perfusion modes, and perfusate temperatures

ASAIO Journal

Volumn 54, Issue 3, 2008, Pages 316-324

  Schreiner, Robert S ^a   Rider, Alan R ^a   Myers, John W ^a   Ji, Bingyang ^a   Kunselman, Allen R ^a   Myers, John L ^a   Ndar, Akif Ü ^a,b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTERIAL FILTERS; BOVINE BLOOD; CARDIOPULMONARY BYPASS; DOPPLER DEVICES; HYPOTHERMIC; MICROEMBOLI; MICROEMBOLI DETECTION; NUMBER AND SIZE; RINGER'S SOLUTION; ULTRASOUND TECHNOLOGY;

FLOW RATE; OXYGENATION; ULTRASONIC APPLICATIONS;

EXPERIMENTS;

AIR EMBOLISM; ARTICLE; BODY TEMPERATURE; CARDIOPULMONARY BYPASS; ECHOLOCATION; FLOW RATE; HYPOTHERMIA; MICROEMBOLISM; PERFUSION; SIMULATION; ANIMAL; BIOLOGICAL MODEL; BIOMEDICAL ENGINEERING; BRAIN INJURY; CATTLE; CLASSIFICATION; CRYOANESTHESIA; ECHOGRAPHY; HUMAN; IN VITRO STUDY; METHODOLOGY; NEWBORN; PULSATILE FLOW; TEMPERATURE;

ANIMALS; BIOMEDICAL ENGINEERING; BRAIN INJURIES; CARDIOPULMONARY BYPASS; CATTLE; EMBOLISM, AIR; HUMANS; HYPOTHERMIA, INDUCED; INFANT, NEWBORN; MODELS, CARDIOVASCULAR; PULSATILE FLOW; TEMPERATURE;

EID: 46249109869     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e31816ecfff     Document Type: Article

References (13)

1. Stump DA: Embolic factors associated with cardiac surgery. Semin Cardiothoracic Vasc Anesth 9: 151-152, 2005.
2. O'Brien JJ, Butterworth J, Hammon JW, Morris KJ, et al: Cerebral emboli during cardiac surgery in children. Anesthesiology 87:1063-1069, 1997.
3. Butler KD, Kurusz M: Embolic events, in Gravlee GP, Davis RF, Kurusz M, Utley JR (eds), Cardiopulmonary Bypass: Principles and Practice, 2nd ed. Philadelphia, Lippincott Williams & Wilkins, 2000, pp. 320-341.
4. Jones TJ, Deal DD, Vernon JC, et al: How effective are cardiopulmonary bypass circuits at removing gaseous microemboli? J Extra Corpor Technol 34: 34-39, 2002.
5. Newburger JW, Jonas RA, Wernovsky G, et al: A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med 329: 1057-1064, 1993.
6. Geissler HJ, Allen SJ, Mehlhorn U, et al: Cooling gradients and formation of gaseous microemboli with cardiopulmonary bypass: an echocardiographic study. Ann Thorac Surg 64: 100-104, 1997.
7. Alkan T, Akçevin A, Ündar A, et al: Effects of pulsatile and nonpulsatile perfusion on vital organ recovery in pediatric heart surgery: a pilot clinical study. ASAIO J 52: 530-535, 2006.
8. Ji B, Ündar: An evaluation of the benefits of pulsatile versus nonpulsatile perfusion during cardiopulmonary bypass procedures in pediatric and adult cardiac patients. ASAIO J 52:357-361, 2006.
9. Ündar A: Pulsatile versus nonpulsatile cardiopulmonary bypass procedures in neonates and infants: from bench to clinical practice. ASAIO J 51: vi-x, 2005.
10. Williams GD, Ramamoorthy C: Brain monitoring and protection during pediatric cardiac surgery. Semin Cardiothoracic Vasc Anesth 11: 23-33, 2007.
11. Nollert G, Nagashima M, Bucerius J, et al: Oxygenation strategy and neurologic damage after deep hypothermic circulatory arrest. I. Gaseous microemboli. J Thorac Cardiovasc Surg 117:1166-1171, 1991.
12. Lynch JE, Pouch A, Sanders R, et al: Gaseous microemboli sizing in extracorporeal circuits using ultrasound backscatter. Ultrasound Med Biol 33: 1661-1675, 2007.
13. Ündar A, Ji B, Kunselman AR, Myers JM: Detection and classification of gaseous microemboli during pulsatile and nonpulsatile perfusion in a simulated neonatal CPB model. ASAIO J 53: 725-729, 2007.