EmaA, a potential virulence determinant of Aggregatibacter actinomycetemcomitans in infective endocarditis

Infection and Immunity

Volumn 76, Issue 6, 2008, Pages 2316-2324

  Tang, Gaoyan ^a   Kitten, Todd ^c   Munro, Cindy L ^c   Wellman, George C ^b   Mintz, Keith P ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; PROTEIN EMAA; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ADHESIN; TRYPSIN;

AGGREGATIBACTER ACTINOMYCETEMCOMITAN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ENDOCARDITIS; ENDOTHELIUM; GRAM NEGATIVE BACTERIUM; HEART VALVE; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; RABBIT; WILD TYPE; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANIMAL; BACTERIAL ENDOCARDITIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; MITRAL VALVE; PATHOGENICITY; PHYSIOLOGY; ULTRASTRUCTURE; VIRULENCE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADHESINS, BACTERIAL; ANIMALS; COLLAGEN TYPE I; ENDOCARDITIS, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; MITRAL VALVE; RABBITS; TRYPSIN; VIRULENCE; VIRULENCE FACTORS;

EID: 46249105826     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00021-08     Document Type: Article

References (39)

1. Asakawa, R., H. Komatsuzawa, T. Kawai, S. Yamada, R. Goncalves, S. Izumi, T. Fujiwara, Y. Nakano, N. Suzuki, Y. Uchida, K. Ouhara, H. Shiba, M. Taubman, H. Kurihara, and M. Sugai. 2003. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans. Mol. Microbiol. 50:1125-1139.
2. Bayer, A. S., S. N. Coulter, C. K. Stover, and W. R. Schwan. 1999. Impact of the high-affinity proline permease gene (putP) on the virulence of Staphylococcus aureus in experimental endocarditis. Infect. Immun. 67:740-744.
3. Becker, J., D. Schuppan, J. Rabanus, R. Rauch, U. Niechoy, and H. Gelderblom. 1991. Immunoelectron microscopic localization of collagens type I, V, VI and of procollagen type III in human periodontal ligament and cementum. J. Histochem. Cytochem. 39:103-110.
4. Brouqui, P., and D. Raoult. 2001. Endocarditis due to rare and fastidious bacteria. Clin. Microbiol. Rev. 14:177-207.
5. Chung, W., and B. Dale. 2004. Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Infect. Immun. 72:352-358.
6. Cole, W., D. Chan, A. Hickey, and D. Wilcken. 1984. Collagen composition of normal and myxomatous human mitral heart valves. Biochem. J. 219:451-460.
7. de Boer, H., L. Comstock, and M. Vasser. 1983. The tac promoter: a functional hybrid derived from the trp and lac promoters. Proc. Natl. Acad. Sci. USA 80:21-25.
8. Durack, D. T., P. B. Beeson, and R. G. Petersdorf. 1973. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br. J. Exp. Pathol. 54:142-151.
9. Durack, D. T. 1975. Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J. Pathol. 115:81-89.
10. Grace, C., R. Levitz, H. Katz-Pollak, and L. Brettman. 1988. Actinobacillus actinomycetemcomitans prosthetic valve endocarditis. Rev. Infect. Dis. 10: 922-929.
11. Grauss, R., M. Hazekamp, F. Oppenhuizen, C. van Munsteren, A. Gittenberger-de Groot, and M. DeRuiter. 2005. Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur. J. Cardiothorac. Surg. 27:566-571.
12. Guntheroth, W. G. 1984. How important are dental procedures as a cause of infective endocarditis? Am. J. Cardiol. 54:797-801.
13. Haubek, D., O. Ennibi, K. Poulsen, N. Benzarti, and V. Baelum. 2004. The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans and progression of periodontal attachment loss. J. Dent. Res. 83:767-770.
14. Herzberg, M. C., G. D. MacFarlane, K. Gong, N. N. Armstrong, A. R. Witt, P. R. Erickson, and M. W. Meyer. 1992. The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect. Immun. 60:4809-4818.
15. Hinton, R. J., J. Lincoln, G. Deutsch, H. Osinska, P. Manning, D. Benson, and K. Yutzey. 2006. Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ. Res. 98:1431-1438.
16. Honma, K., H. Kuramitsu, R. Genco, and A. Sharma. 2001. Development of a gene inactivation system for Bacteroides forsythus: construction and characterization of a BspA mutant. Infect. Immun. 69:4686-4690.
17. Hook, E. W., III, and M. A. Sande. 1974. Role of the vegetation in experimental Streptococcus viridans endocarditis. Infect. Immun. 10:1433-1438.
18. Ishikawa, J., K. Kario, Y. Matsui, S. Shibasaki, M. Morinari, R. Kaneda, S. Hoshide, K. Eguchi, Y. Hojo, and K. Shimada. 2005. Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. Hypertens Res. 28:995-1001.
19. Kolenbrander, P. 2000. Oral microbial communities: biofilms, interactions, and genetic systems. Annu. Rev. Microbiol. 54:413-437.
20. Kozarov, E., B. Dorn, C. Shelburne, W. J. Dunn, and A. Progulske-Fox. 2005. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler. Thromb. Vasc. Biol. 25:e17-18.
21. Kusano, A., Y. Seyama, M. Nagai, M. Shibano, and G. Kusano. 2001. Effects of fukinolic acid and cimicifugic acids from Cimicifuga species on collagenolytic activity. Biol. Pham. Bull. 24:1198-1201.
22. Mintz, K. 2004. Identification of an extracellular matrix protein adhesin, EmaA, which mediates the adhesion of Actinobacillus actinomycetemcomitans to collagen. Microbiology 150:2677-2688.
23. Mintz, K., and P. Fives-Taylor. 1999. Binding of the periodontal pathogen Actinobacillus actinomycetemcomitans to extracellular matrix proteins. Oral Microbiol. Immunol. 14:109-116.
24. Nakano, K., H. Inaba, R. Nomura, H. Nemoto, K. Tamura, E. Miyamoto, H. Yoshioka, K. Taniguchi, A. Amano, and T. Ooshima. 2007. Detection and serotype distribution of Actinobacillus actinomycetemcomitans in cardiovascular specimens from Japanese patients. Oral Microbiol. Immunol. 22:136-139.
25. Paik, S., L. Senty, S. Das, J. Noe, C. Munro, and T. Kitten. 2005. Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis. Infect. Immun. 73:6064-6074.
26. Paturel, L., J. P. Casalta, G. Habib, M. Nezri, and D. Raoult. 2004. Actinobacillus actinomycetemcomitans endocarditis. Clin. Microbiol. Infect. 10:98-118.
27. Pease, D. 1964. Histological technique for electron microscopy, p.381. Academic Press, New York, NY.
28. Permpanich, P., M. J. Kowolik, and D. M. Galli. 2006. Resistance of fluorescent-labelled Actinobacillus actinomycetemcomitans strains to phagocytosis and killing by human neutrophils. Cell. Microbiol. 8:72-84.
29. Roggenkamp, A., N. Ackermann, C. Jacobi, K. Truelzsch, H. Hoffmann, and J. Heesemann. 2003. Molecular analysis of transport and oligomerization of the Yersinia enterocolitica adhesin YadA. J. Bacteriol. 185:3735-3744.
30. Rose, J., D. Meyer, and P. Fives-Taylor. 2003. Aae, an autotransporter involved in adhesion of Actinobacillus actinomycetemcomitans to epithelial cells. Infect. Immun. 71:5284-5293.
31. Ruiz, T., C. Lenox, M. Radermacher, and K. Mintz. 2006. Novel surface structures are associated with the adhesion of Actinobacillus actinomycetemcomitans to collagen. Infect. Immun. 74:6163-6170.
32. Sharma, A., H. Sojar, I. Glurich, K. Honma, H. Kuramitsu, and R. Genco. 1998. Cloning, expression, and sequencing of a cell surface antigen containing a leucine-rich repeat motif from Bacteroides forsythus ATCC 43037. Infect. Immun. 66:5703-5710.
33. Suresh, A., M. Stemerman, and T. Spaet. 1973. Rabbit heart valve basement membrane: low platelet reactivity. Blood 41:359-367.
34. Tang, G., T. Ruiz, R. Barrantes-Reynolds, and K. Mintz. 2007. Molecular heterogeneity of EmaA, an oligomeric autotransporter adhesin of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Microbiology 153:2447-2457.
35. Veltrop, M. H., M. J. Bancsi, R. M. Bertina, and J. Thompson. 2000. Role of monocytes in experimental Staphylococcus aureus endocarditis. Infect. Immun. 68:4818-4821.
36. Weber, K. 1998. Monitoring vascular sclerosis in hypertension: a new window of opportunity. Circulation 98:498-500.
37. Wilson, W., K. A. Taubert, M. Gewitz, P. B. Lockhart, L. M. Baddour, M. Levison, A. Bolger, C. H. Cabell, M. Takahashi, R. S. Baltimore, J. W. Newburger, B. L. Strom, L. Y. Tani, M. Gerber, R. O. Bonow, T. Pallasch, S. T. Shulman, A. H. Rowley, J. C. Burns, P. Ferrieri, T. Gardner, D. Goff, D. T. Durack; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesia; Quality of Care and Outcomes Research Interdisciplinary Working Group; and American Dental Association. 2007. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J. Am. Dent. Assoc. 138:739-745, 747-760.
38. Winkler, J., S. John, R. Kramer, C. Hoover, and P. Murray. 1987. Attachment of oral bacteria to a basement-membrane-like matrix and to purified matrix proteins. Infect. Immun. 55:2721-2726.
39. Yue, G., J. Kaplan, D. Furgang, K. Mansfield, and D. Fine. 2007. A second Aggregatibacter actinomycetemcomitans autotransporter adhesin exhibits specificity for buccal epithelial cells in humans and old world primates. Infect. Immun. 75:4440-4448.