Small mammal MRI imaging in spinal cord injury: A novel practical technique for using a 1.5 T MRI

Journal of Neuroscience Methods

Volumn 172, Issue 2, 2008, Pages 245-249

  Levene, Howard B ^a   Mohamed, Feroze B ^a   Faro, Scott H ^a   Seshadri, Asha B ^a   Loftus, Christopher M ^a   Tuma, Ronald F ^a,b   Jallo, Jack I ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Physiology ^*  (United States)

Author keywords

1.5 T; Magnetic resonance imaging; Mouse; Murine; Rodent; Small animal; Spinal cord injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; BRAIN REGION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; KINEMATICS; MEDICAL INSTRUMENTATION; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SPINAL CORD INJURY; THORACIC SPINAL CORD; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ANIMALS; ARTIFACTS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; NERVE FIBERS, MYELINATED; NEURONS; SPINAL CORD; SPINAL CORD INJURIES;

EID: 46249097120     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2008.05.009     Document Type: Article

References (56)

1. Adams W.H. The spine. Clin Tech Small Anim Pract 14 3 (1999) 148-159
2. Baker K.A., and Hagg T. An adult rat spinal cord contusion model of sensory axon degeneration: the estrus cycle or a preconditioning lesion do not affect outcome. J Neurotrauma 22 4 (2005) 415-428
3. Basso D.M., Beattie M.S., Bresnahan J.C., Anderson D.K., Faden A.I., Gruner J.A., et al. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma 13 (1996) 343-359
4. Behrmann D.L., Bresnahan J.C., and Beattie M.S. Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp Neurol 126 (1994) 61-75
5. Bilgen M., and Narayana P.A. A pharmacokinetic model for quantitative evaluation of spinal cord injury with dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med 46 6 (2001) 1099-1106
6. Biton I.E., Duncan I.D., and Cohen Y. High b-value q-space diffusion MRI in myelin-deficient rat spinal cords. Magn Reson Imaging 24 (2006) 161-166
7. Blight A.R. Miracles and molecules-progress in spinal cord repair. Nat Neurosci 5 Suppl. (2002) 1051-1054
8. Bracken M.B. Methylprednisolone and acute spinal cord injury: an update of the randomized evidence. Spine 26 24 Suppl. (2001) S47-S54
9. Bracken M.B., Shepard M.J., Holford T.R., Leo-Summers L., Aldrich E.F., Fazl M., et al. Administration of methylprednisolone for 24 or 48 h or tirilazad mesylate for 48 h in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277 (1997) 1597-1604
10. Dohrmann G.J. Experimental spinal cord trauma. A historical review. Arch Neurol 27 6 (1972) 468-473
11. Driehuys B., Nouls J., Badea A., Bucholz E., Ghaghada K., Petiet A., and Hedlund L.W. Small animal imaging with magnetic resonance microscopy. ILAR J 49 (2008) 35-53
12. Ducker T.B., and Zeidman S.M. Spinal cord injury. Role of steroid therapy. Spine 19 20 (1994) 2281-2287
13. Dumont A.S., Dumont R.J., and Oskouian R.J. Will improved understanding of the pathophysiological mechanisms involved in acute spinal cord injury improve the potential for therapeutic intervention?. Curr Opin Neurol (2002) 713-720
14. Ferguson A.R., Hook M.A., Garcia G., Bresnahan J.C., Beattie M.S., and Grau J.W. A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injury. J Neurotrauma 21 (2004) 1601-1613
15. Ford J.C., Hackney D.B., Joseph P.M., Phelan M., Alsop D.C., Tabor S.L., et al. A method for in vivo high resolution MRI of rat spinal cord injury. Magn Reson Med 31 (1994) 218-223
16. Gareis D., Wichmann T., Lanz T., Melkus G., Horn M., and Jakob P.M. Mouse MRI using phased-array coils. NMR Biomed 20 (2007) 326-334
17. Gaviria M., Haton H., Sandillon F., and Privat A. A mouse model of acute ischemic spinal cord injury. J Neurotrauma 19 (2002) 205-221
18. Gutierrez P.A., Young R.R., and Vulpe M. Spinal cord injury. An overview. Urol Clin North Am 20 (1993) 373-382
19. Hauben E., Gothilf A., Cohen A., Butovsky O., Nevo U., Smirnov I., et al. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J Neurosci 23 (2003) 8808-8819
20. Hulsebosch C.E. Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Educ 26 1-4 (2002) 238-255
21. Hurlbert R.J. The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine 26 24 Suppl. (2001) S39-S46
22. Ibarra A., Hauben E., Butovsky O., and Schwartz M. The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats. Eur J Neurosci 19 (2004) 2984-2990
23. Jackson A.B., Dijkers M., Devivo M.J., and Poczatek R.B. A demographic profile of new traumatic spinal cord injuries: change and stability over 30 years. Arch Phys Med Rehabil 85 (2004) 1740-1748
24. Kakulas B.A. Neuropathology: the foundation for new treatments in spinal cord injury. Spinal Cord 42 10 (2004) 549-563
25. Kanchiku T., Taguchi T., Kaneko K., Yonemura H., Kawai S., and Gondo T. A new rabbit model for the study on cervical compressive myelopathy. J Orthop Res 19 (2001) 605-613
26. Kastin A.J., and Pan W. Targeting neurite growth inhibitors to induce CNS regeneration. Curr Pharm Des 11 10 (2005) 1247-1253
27. Kipnis J., Mizrahi T., Hauben E., Shaked I., Shevach E., and Schwartz M. Neuroprotective autoimmunity: naturally occurring CD4 + CD25 + regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci U S A 99 (2002) 15620-15625
28. Kuhn P.L., and Wrathall J.R. A mouse model of graded contusive spinal cord injury. J Neurotrauma 15 2 (1998) 125-140
29. Lammertse D.P. Update on pharmaceutical trials in acute spinal cord injury. J Spinal Cord Med 27 4 (2004) 319-325
30. Legos J.J., Gritman K.R., Tuma R.F., and Young W.F. Coadministration of methylprednisolone with hypertonic saline solution improves overall neurological function and survival rates in a chronic model of spinal cord injury. Neurosurgery 49 (2001) 1427-1433
31. Levene H.B., Erb C.J., Gaughan J.P., Loftus C.M., Tuma R.F., and Jallo J.I. Hypertonic saline as a treatment for acute spinal cord injury: effects on somatic and autonomic outcomes as observed in a mouse model. Clin Neurosurg (2007) 213-219
32. Li Y., Oskouian R.J., Day Y.J., Kern J.A., and Linden J. Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices. J Neurosurg Spine 4 (2006) 165-173
33. Linn J., Schwarz F., Schichor C., and Wiesmann M. Cranial MRI of small rodents using a clinical MR scanner. Methods 43 (2007) 2-11
34. Ma M., Basso D.M., Walters P., Stokes B.T., and Jakeman L.B. Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouse. Exp Neurol 169 (2001) 239-254
35. Merola A., O'Brien M.F., Castro B.A., Smith D.A., Eule J.M., Lowe T.G., et al. Histologic characterization of acute spinal cord injury treated with intravenous methylprednisolone. J Orthop Trauma 16 (2002) 155-161
36. Noble L.J., and Maxwell D.S. Morphometric analysis of effects of spinal cord transection. Exp Neurol 79 1 (1983) 200-211
37. Nomura H., Tator C.H., and Shoichet M.S. Bioengineered strategies for spinal cord repair. J Neurotrauma 23 (2006) 496-507
38. Popovich P.G., and Jones T.B. Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol Sci 24 1 (2003) 13-17
39. Rabchevsky A.G., Fugaccia I., Sullivan P.G., Blades D.A., and Scheff S.W. Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci Res 68 (2002) 7-18
40. Scheff S.W., Saucier D.A., and Cain M.E. A statistical method for analyzing rating scale data: the BBB locomotor score. J Neurotrauma 19 (2002) 1251-1260
41. Scheff S.W., Rabchevsky A.G., Fugaccia I., Main J.A., and Lumpp Jr. J.E. Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J Neurotrauma 20 (2003) 179-193
42. Seki T., Hida K., Tada M., Koyanagi I., and Iwasaki Y. Graded contusion model of the mouse spinal cord using a pneumatic impact device. Neurosurgery 50 (2002) 1075-1081 discussion 1081-2
43. Spera P.A., Arfors K.E., Vasthare U.S., Tuma R.F., and Young W.F. Effect of hypertonic saline on leukocyte activity after spinal cord injury. Spine 23 (1998) 2444-2448 discussion 2448-9
44. Spera P.A., Vasthare U.S., Tuma R.F., and Young W.F. The effects of hypertonic saline on spinal cord blood flow following compression injury. Acta Neurochir (Wien) 142 (2000) 811-817
45. Spinal Cord Injury. Facts and figures at a glance. J Spinal Cord Med 28 (2005) 379-380
46. Stokes B.T., and Jakeman L.B. Experimental modelling of human spinal cord injury: a model that crosses the species barrier and mimics the spectrum of human cytopathology. Spinal Cord 40 3 (2002) 101-109
47. Stroman P.W. Magnetic resonance imaging of neuronal function in the spinal cord: spinal FMRI. Clin Med Res 3 3 (2005) 146-156
48. Sumas M.E., Legos J.J., Nathan D., Lamperti A.A., Tuma R.F., and Young W.F. Tonicity of resuscitative fluids influences outcome after spinal cord injury. Neurosurgery 48 (2001) 167-172 discussion 172-3
49. Talac R., Friedman J.A., Moore M.J., Lu L., Jabbari E., Windebank A.J., et al. Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies. Biomaterials 25 (2004) 1505-1510
50. Tsai E.C., and Tator C.H. Neuroprotection and regeneration strategies for spinal cord repair. Curr Pharm Des 11 10 (2005) 1211-1222
51. Tsai E.C., Dalton P.D., Shoichet M.S., and Tator C.H. Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection. J Neurotrauma 21 (2004) 789-804
52. Tuma R.F., Vasthare U.S., Arfors K.E., and Young W.F. Hypertonic saline administration attenuates spinal cord injury. J Trauma 42 (1997) S54-S60
53. Xiang S., Pan W., and Kastin A.J. Strategies to create a regenerating environment for the injured spinal cord. Curr Pharm Des 11 (2005) 1267-1277
54. Yeo S.J., Hwang S.N., Park S.W., Kim Y.B., Min B.K., Kwon J.T., and Suk J.S. Development of a rat model of graded contusive spinal cord injury using a pneumatic impact device. J Korean Med Sci 19 (2004) 574-580
55. Young W.F., Rosenwasser R.H., Vasthare U.S., and Tuma R.F. Preservation of post-compression spinal cord function by infusion of hypertonic saline. J Neurosurg Anesthesiol 6 (1994) 122-127
56. Zhang Z., Guth L., and Steward O. Mechanisms of motor recovery after subtotal spinal cord injury: insights from the study of mice carrying a mutation (WldS) that delays cellular responses to injury. Exp Neurol 149 (1998) 221-229