Severe neonatal myasthenia due to maternal anti-MuSK antibodies

Neuromuscular Disorders

Volumn 18, Issue 6, 2008, Pages 443-446

  Béhin, Anthony ^a   Mayer, Michèle ^b   Kassis Makhoul, Bouchera ^c   Jugie, Myriam ^d   Espil Taris, Caroline ^e   Ferrer, Xavier ^f   Chatenoud, Lucienne ^g   Laforêt, Pascal ^a   Eymard, Bruno ^a  

^a Institut de Myologie   (France)

^b ARMAND TROUSSEAU HOSPITAL   (France)

^c centre hospitalier de Calais   (France)

^d centre hospitalier régional de Troyes   (France)

^e HÔPITAL PELLEGRIN   (France)

^f Groupe Hospitalier Sud   (France)

^g HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Anti MuSK antibodies; Myasthenia gravis; Neonatal myasthenia

Indexed keywords

ANTIBODY; MUSK ANTIBODY;

ADULT; ANTIBODY DETECTION; ARTICLE; CASE REPORT; FEMALE; HUMAN; HYDRAMNIOS; MALE; MUSCLE HYPOTONIA; MYASTHENIA GRAVIS; NEWBORN; NEWBORN DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRIDOR; SUCKING;

ADULT; ANTIBODIES; FEMALE; HUMANS; INFANT, NEWBORN; MOTHER-CHILD RELATIONS; MYASTHENIA GRAVIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC;

EID: 46149127097     PISSN: 09608966     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nmd.2008.03.006     Document Type: Article

References (37)

1. Namba T., Brown S.B., and Grob D. Neonatal myasthenia gravis: report of two cases and review of the literature. Pediatrics 45 (1970) 488-504
2. Eymard B. Neonatal myasthenia gravis clinical and pathophysiological aspects. Advances in organ biology vol. 2 (1997), JAI Press Inc. pp. 235-247
3. Eymard B., Vernet-der Garabedian B., Berrih-Aknin S., Pannier C., Bach J.F., and Morel E. Anti-acetylcholine receptor antibodies in neonatal myasthenia gravis: heterogeneity and pathogenic significance. J Autoimmun 4 (1991) 185-195
4. Shepard M.K. Arthrogryposis multiplex in sibs. Birth Defects Orig Artic Ser 7 (1971) 127
5. Vincent A., Newland C., Brueton L., et al. Arthrogryposis multiplex congenital with autoantibodies specific for fetal antigen. Lancet 346 (1995) 24-25
6. Hesselmans L.F., Jennekens F.G., Van den Oord C.J., Veldman H., and Vincent A. Development of innervation of skeletal muscle fibers in man: relation to acetylcholine receptors. Anat Rec 236 (1993) 553-562
7. Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., and Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7 (2001) 365-368
8. Vincent A., Bowen J., Newsom-Davis J., and McConville J. Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targets. Lancet Neurol 2 (2003) 99-106
9. DeChiara T.M., Bowen D.C., Valenzuela D.M., et al. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 85 (1996) 501-512
10. Heckmat J.Z., Platczek M., Thomson A.H., Dubowitz V., and Watson G. An unusual case of neonatal myasthenia. J Child Neurol 2 (1987) 63-66
11. Mier A.K., and Havard C.W.H. Diaphragmatic myasthenia in mother and child. Postgrad Med J 61 (1985) 725-727
12. Melber D. Maternal fetal transmission of myasthenia gravis with acetylcholine receptor antibody. N. Engl. J. Med. 318 (1988) 996
13. Ramirez C., de Seze J., Delrieu O., et al. Myasthénie auto-immune et grossesse: évolution clinique, accouchement et post-partum. Rev Neurol (Paris) 162 (2006) 330-338
14. Holmes L.B., Driscoll S.G., and Bradley W.G. Contractures in a newborn infant of a mother with myasthenia gravis. Pediatr Res 13 (1979) 486
15. Pasternak J.F., Hageman J., Adams M.A., Philip A.G., and Gardner T.H. Exchange transfusion in neonatal myasthenia. J Pediatr 99 4 (1981) 644-646
16. Dalton P., Clover L., Wallerstein R., et al. Fetal arthrogryposis and maternal serum antibodies. Neuromuscul Disord 16 (2006) 481-491
17. Evoli A., Tonali P., Padua L., et al. Clinical correlates with anti-MuSK antibodies in generalised seronegative myasthenia gravis. Brain 126 (2003) 2304-2311
18. Barnes P.R., Kanabar D.J., Brueton L., Huson S.M., Mann N.P., and Hilton-Jones D. Recurrent congenital arthrogryposis leading to diagnosis of myasthenia gravis in an initially asymptomatic mother. Neuromuscul Disord 5 (1995) 59-65
19. Dinger J., and Prager B. Arthrogryposis multiplex in a newborn of a myasthenic mother. Case report and literature. Neuromuscul Disord 3 (1993) 335-339
20. Dulitzky F., Sirota L., Landman J., and Homburg R. An infant with multiple deformations born to a myasthenic mother. Helv Paediatr Acta 42 (1987) 173-176
21. Moutard-Codou M.L., Delleur M.M., Dulac O., Morel E., Voyer M., and De Gamara E. Myasthénie néonatale sévère avec arthrogrypose. Presse Med 16 (1987) 615-618
22. Stoll C., Ehret-Mentre M.C., Treisser A., and Tranchant C. Prenatal diagnosis of congenital myasthenia with arthrogryposis in a myasthenic mother. Prenat Diagn 11 (1991) 17-22
23. Eymard B., Morel E., Dulac O., et al. Myasthenia and pregnancy: clinical and immunological study of 42 cases. Rev Neurol (Paris) 145 (1989) 696-701
24. Tranchant C., Ehret C., Labouret P., and Waretr J.M. Arthrogryposis and maternal myasthenia gravis. Risk of recurrence. Rev Neurol (Paris) 147 (1991) 63-64
25. Carr S.R., Gilchrist J.M., Abuelo D.N., and Clark D. Treatment of antenatal myasthenia gravis. Obstet Gynecol 78 (1991) 485-489
26. Cantagrel S., Maury L., Yamamoto A.M., Maheut J., Toutain A., and Castelnau P. Akinesia, arthrogryposis, craniosynostosis: a presentation of neonatal myasthenia with fetal onset. Am J Perinatol 19 (2002) 297-301
27. Brueton L.A., Huson S.M., Cox P.M., et al. Asymptomatic maternal myasthenia as a cause of the Pena-Shokeir phenotype. Am J Med Genet 92 (2000) 1-6
28. Morel E., Eymard B., Vernet-der Garabedian B., Pannier C., Dulac O., and Bach J.F. Neonatal myasthenia gravis: a new clinical and immunologic appraisal on 30 cases. Neurology 38 (1988) 138-142
29. Apel E.D., Glass D.J., Moscoso L.M., Yancopoulos G.D., and Sanes J.R. Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Neuron 18 (1997) 623-635
30. Glass D.J., Bowen D.C., Stitt T.N., et al. Agrin acts via a MuSK receptor complex. Cell 85 (1996) 513-523
31. Bezakova G., and Ruegg M.A. New insights in the roles of agrin. Nat Rev Mol Cell Biol 4 (2003) 295-298
32. Herbst R., and Burden S.J. The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. EMBO J 19 (2000) 67-77
33. Schaeffer L., de Kerchove d'Exaerde A., and Changeux J.P. Targeting transcription to the neuromuscular synapse. Neuron 31 (2001) 15-22
34. Chevessier F., Faraut B., Ravel-Chapuis A., et al. MUSK, a new target for mutations causing congenital myasthenic syndrome. Hum Mol Genet 13 (2004) 3229-3240
35. Shigemoto K., Kubo S., Maruyama N., et al. Induction of myasthenia by immunization against muscle specific kinase. J Clin Invest 116 (2006) 1016-1024
36. McConville J., Farrugia M.E., Beeson D., et al. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann Neurol 55 (2004) 580-584
37. Malek A., Sager R., Kunh P., Nicolaides K.H., and Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol 36 (1996) 248-255