Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

International Journal of Hematology

Volumn 87, Issue 4, 2008, Pages 363-370

  Nakayama, Takayuki ^a   Matsushita, Tadashi ^a   Yamamoto, Koji ^b   Mutsuga, Noriko ^b   Kojima, Tetsuhito ^c   Katsumi, Akira ^a   Nakao, Norihiko ^a   Sadler, J Evan ^d   Naoe, Tomoki ^a   Saito, Hidehiko ^e  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NAGOYA CENTRAL HOSPITAL   (Japan)

Author keywords

A1 domain; Alanine scanning mutagenesis; Sulfatide; Von Willebrand factor

Indexed keywords

AMINO ACID; ARGININE; BOTROCETIN; CERAMIDE; EPITOPE; GALACTOSE; GLYCOPROTEIN IB; LIGAND; LYSINE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; SNAKE VENOM; SULFATIDE; VON WILLEBRAND FACTOR;

ALANINE SCANNING MUTAGENESIS; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; HEMOSTASIS; KIDNEY TUBULE CELL; MUTAGENESIS; MUTATION; OLIGODENDROGLIA; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; THROMBOCYTE; THROMBOCYTE AGGREGATION; TUMOR CELL;

ALANINE; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HUMANS; IONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SULFOGLYCOSPHINGOLIPIDS; VON WILLEBRAND FACTOR;

EID: 46149123665     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-008-0065-8     Document Type: Article

References (36)

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