Intravenous morphine titration to treat severe pain in the ED

American Journal of Emergency Medicine

Volumn 26, Issue 6, 2008, Pages 676-682

  Lvovschi, Virginie ^a   Aubrun, Frédéric ^a   Bonnet, Pascale ^a   Bouchara, Anna ^a   Bendahou, Mouhssine ^a   Humbert, Béatrice ^a   Hausfater, Pierre ^a   Riou, Bruno ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ADULT; AGED; ALLERGY; ANALGESIA; ARTICLE; CLINICAL PROTOCOL; CONFIDENCE INTERVAL; DISEASE SEVERITY; DIZZINESS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; EMERGENCY CARE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; PRURITUS; RESPIRATION DEPRESSION; UNSPECIFIED SIDE EFFECT; URINE RETENTION; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; DOSE-RESPONSE RELATIONSHIP, DRUG; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MORPHINE; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC;

EID: 46149121265     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2007.10.025     Document Type: Article

References (28)

1. British Association for Emergency Medicine. Clinical effectiveness standard 3: pain. January 2006. Available at:. http://www.emergencymed.org.uk
2. Brown J.C., Klein E., Lewis C.W., Johnston B.D., and Cummings P. Emergency department analgesia for fracture pain. Ann Emerg Med 42 (2003) 197-205
3. Todd K.H. Emergency medicine and pain: a topography of influence. Ann Emerg Med 43 (2004) 504-506
4. Rupp T., and Delaney K.A. Inadequate analgesia in emergency medicine. Ann Emerg Med 43 (2004) 494-503
5. Aubrun F., Monsel S., Langeron O., Coriat P., and Riou B. Postoperative titration of intravenous morphine. Eur J Anaesthesiol 18 (2001) 159-165
6. Aubrun F., Langeron O., Quesnel C., Coriat P., and Riou B. Relationship between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. Anesthesiology 98 (2003) 1415-1421
7. Aubrun F., Salvi N., Coriat P., and Riou B. Sex-and age-related in morphine requirements for postoperative pain relief. Anesthesiology 103 (2005) 156-160
8. Gallagher E.J., Esses D., Lee C., Lahn M., and Bijur P.E. Randomized clinical trial of morphine in acute abdominal pain. Ann Emerg Med 48 (2006) 150-160
9. Bijur P.E., Kenny M.K., and Gallagher E.J. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med 46 (2005) 362-367
10. Kendall J.M., Reeves B.C., Latter V.S., and The Nasal Diamorphine Trial Group. Multicentre randomized controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. Br Med J 322 (2001) 261-265
11. Mercadante S., Villari P., Ferrera P., Casuccio A., and Fulfaro F. Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion. Cancer 95 (2002) 203-208
12. Harris J.T., Suresh Kumar K., and Rajagopal M.R. Intravenous morphine for rapid control of severe cancer pain. Palliat Med 17 (2003) 248-256
13. Bradshaw M., and Sen A. Use of a prophylactic antiemetic with morphine in acute pain: randomised controlled trial. Emerg Med J 23 (2006) 210-213
14. Huskisson E.C. Measurement of pain. Lancet 2 (1974) 1127-1131
15. DeLoach L.J., Higgins M.S., Caplan A.B., and Stigg J.L. The visual analog scale in the immediate postoperative period: intrasubject variability and correlation with a numeric scale. Anesth Analg 86 (1998) 102-106
16. Ramsay M.A., Savege T.M., Simpson B.R., and Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J 2 (1974) 656-659
17. Aubrun F., Monsel S., Langeron O., Coriat P., and Riou B. Postoperative titration of intravenous morphine in the elderly patients. Anesthesiology 96 (2002) 17-23
18. Borgbjerg F.M., Nielsen K., and Franks J. Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers. Pain 64 (1996) 123-128
19. Paqueron X., Lumbroso A., Mergoni P., Aubrun F., Langeron O., Coriat P., and Riou B. Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration?. Br J Anaesth 89 (2002) 697-701
20. Aubrun F., Hradzilova O., Langeron O., Coriat P., and Riou B. A high VAS score and sedation are associated with the need for rescue SC morphine after IV titration. Can J Anesth 51 (2004) 969-974
21. Ricard-Hibon A., Belpomme V., Chollet C., Devaud M.L., Adnet F., Borron S., Mantz J., and Marty J. Compliance with a morphine protocol and effect of pain relief in out-of hospital patients. J Emerg Med 33 (2007) [in press]
22. Simonnet G., and Rivat C. Opioid-induced hyperalgesia: abnormal or normal pain?. Neuroreport 14 (2003) 1-7
23. Aubrun F., Kalfon F., Mottet P., Bellanger A., Langeron O., Coriat P., and Riou B. Adjunctive analgesia with intravenous propacetamol does not reduce morphine-related adverse effects. Br J Anaesth 90 (2003) 314-319
24. Marret E., Kurdi O., Zufferey P., and Bonnet F. Effects of nonsteroidal anti-inflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 102 (2005) 1249-1260
25. Elia N., Lysakowski C., and Tramer M.R. Does multimodal analgesia with acetaminophen, non steroidal anti-inflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 103 (2005) 1296-1304
26. Pico L., Hernot S., Nègre I., Samii K., and Fletcher D. Peroperative titration of morphine improves immediate postoperative analgesia after total hip arthroplasty. Can J Anesth 47 (2000) 309-314
27. Aubrun F., Amour J., Rosenthal D., Coriat P., and Riou B. Effects of a loading dose of morphine before intravenous morphine titration for postoperative pain relief. A randomized, double blind, placebo-control study. Br J Anaesth 98 (2007) 124-130
28. Jones J.S., Johnson K., and McNinch M. Age as a risk factor for inadequate emergency department analgesia. Am J Emerg Med 14 (1996) 157-160