High prevalence of hypovitaminosis D and secondary hyperparathyroidism in elders living in nonprofit homes in South Brazil

Endocrine

Volumn 33, Issue 1, 2008, Pages 95-100

  Scalco, Rosana ^a   Premaor, Melissa O ^a   Fröehlich, Pedro E ^b   Furlanetto, Tania W ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Aged; Secondary hyperparathyroidism; Thiazides; Vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; ALKALINE PHOSPHATASE; CALCIUM; CREATININE; FUROSEMIDE; HYDROCHLOROTHIAZIDE; MAGNESIUM; PARATHYROID HORMONE; PHOSPHORUS;

AGED; ARTICLE; BRAZIL; ELDERLY CARE; EXERCISE; FEMALE; GLOMERULUS FILTRATION RATE; HOME; HUMAN; MAJOR CLINICAL STUDY; MALE; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROFIT; RISK FACTOR; SECONDARY HYPERPARATHYROIDISM; SMOKING; SUN EXPOSURE; VITAMIN D DEFICIENCY;

EID: 46149085631     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-008-9061-2     Document Type: Article

References (32)

1. M.F. Holick, Vitamin D deficiency. N. Engl. J. Med. 357(3), 266-281 (2007)
2. P. Lips, Vitamin D deficiency and Secondary Hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr. Rev. 22, 477-501 (2001)
3. A. Webb, Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog. Biophys. Mol. Biol. 92, 17-25 (2006)
4. L. Mosekilde, Vitamin D and the elderly. Clin. Endocrinol. (Oxf) 62(3), 265-281 (2005)
5. P. Lips, D. Hosking, K. Lippuner, J.M. Norquist, L. Wehren, G. Maalouf et al., The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J. Intern. Med. 260(3), 245-254 (2006)
6. E. Linhares, D. Jones, J. Round, R. Edwards, Effect of nutrition on vitamin D status: studies on healthy and poorly nourished Brazilian children. Am. J. Clin. Nutr. 39(4), 625-630 (1984)
7. G. Saraiva, M. Cendoroglo, L. Ramos, L. Araújo, J. Vieira, S. Maeda et al., [Prevalence of vitamin D deficiency, insufficiency and secondary hyperparathyroidism in the elderly inpatients and living in the community of the city of São Paulo, Brazil]. Arq. Bras. Endocrinol. Metabol. 51(3), 437-442 (2007)
8. G.L. Saraiva, M.S. Cendoroglo, L.R. Ramos, L.M. Araujo, J.G. Vieira, I. Kunii et al., Influence of ultraviolet radiation on the production of 25 hydroxyvitamin D in the elderly population in the city of Sao Paulo (23 degrees 34'S), Brazil. Osteoporos. Int. 16(12), 1649-1654 (2005)
9. M.O. Premaor, G.V. Alves, L.B. Crossetti, T.W. Furlanetto, Hyperparathyroidism secondary to hypovitaminosis D in hypoalbuminemic is less intense than in normoalbuminemic patients: a prevalence study in medical inpatients in southern Brazil. Endocrine 24(1), 47-53 (2004)
10. O. Sahota, K. Gaynor, R.H. Harwood, D.J. Hosking, Hypovitaminosis D and 'functional hypoparathyroidism'-the NoNoF (Nottingham Neck of Femur) study. Age Ageing 30(6), 467-472 (2001)
11. S. Patel, S. Hyer, J. Barron, Glomerular filtration rate is a major determinant of the relationship between 25-hydroxyvitamin D and parathyroid hormone. Calcif. Tissue Int. 80(4), 221-226 (2007)
12. R. Vieth, Y. Ladak, P.G. Walfish, Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J. Clin. Endocrinol. Metab. 88(1), 185-191 (2003)
13. S. Adami, O. Viapiana, D. Gatti, L. Idolazzi, M. Rossini, Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone 42(2), 267-270 (2008)
14. O. Sahota, M.K. Mundey, P. San, I.M. Godber, D.J. Hosking, Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos. Int. 17(7), 1013-1021 (2006)
15. J.S. Chen, P.N. Sambrook, L. March, I.D. Cameron, R.G. Cumming, J.M. Simpson et al., Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality. Clin. Endocrinol. (Oxf) 68(2), 290-298 (2008)
16. L. Steingrimsdottir, O. Gunnarsson, O.S. Indridason, L. Franzson, G. Sigurdsson, Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 294(18), 2336-2341 (2005)
17. M.S. Stein, L. Flicker, S.C. Scherer, L.M. Paton, M.L. O'Brien, S.C. Walton et al., Relationships with serum parathyroid hormone in old institutionalized subjects. Clin. Endocrinol. (Oxf) 54(5), 583-592 (2001)
18. P.J. Drinka, P.F. Krause, L.J. Nest, B.M. Goodman, Determinants of parathyroid hormone levels in nursing home residents. J. Am. Med. Dir. Assoc. 8(5), 328-331 (2007)
19. M. Clements, L. Johnson, D. Fraser, A new mechanism for induced vitamin D deficiency in calcium deprivation. Nature 325(6099), 62-65 (1987)
20. H. Bischoff-Ferrari, The 25-hydroxyvitamin D threshold for better health. J. Steroid Biochem. Mol. Biol. 103(3-5), 614-619 (2007)
21. H. Bischoff-Ferrari, W. Willett, J. Wong, E. Giovannucci, T. Dietrich, B. Dawson-Hughes, Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293(18), 2257-2264 (2005)
22. K. Nakamura, M. Nashimoto, Y. Tsuchiya, T. Saito, T. Nishiwaki, K. Ueno, et al., Threshold value of serum 25-hydroxyvitamin D concentration in relation to elevated serum parathyroid hormone concentrations in elderly Japanese women. J. Bone Miner. Metab. 24(5), 395-400 (2006)
23. D.G. von Muhlen, G.A. Greendale, C.F. Garland, L. Wan, E. Barrett-Connor, Vitamin D, parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo Study. Osteoporos. Int. 16(12), 1721-1726 (2005)
24. M.O. Premaor, P. Paludo, D. Manica, A.P. Paludo, E.R. Rossatto, R. Scalco et al. Hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil. J. Endocrinol. Invest. (2008) (in press)
25. U. Krause, A. Zielke, H. Schmidt-Gayk, W. Ehrenthal, J. Beyer, Direct tubular effect on calcium retention by hydrochlorothiazide. J. Endocrinol. Invest. 12(8), 531-535 (1989)
26. L. Rejnmark, P. Vestergaard, L. Heickendorff, F. Andreasen, L. Mosekilde, Effects of thiazide- and loop-diuretics, alone or in combination, on calcitropic hormones and biochemical bone markers: a randomized controlled study. J. Intern. Med. 250(2), 144-153 (2001)
27. T. Nijenhuis, V. Vallon, A.W. van der Kemp, J. Loffing, J.G. Hoenderop, R.J. Bindels, Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J. Clin. Invest. 115(6), 1651-1658 (2005)
28. C. Bazzini, V. Vezzoli, C. Sironi, S. Dossena, A. Ravasio, S. De Biasi et al., Thiazide-sensitive NaCl-cotransporter in the intestine: possible role of hydrochlorothiazide in the intestinal Ca2+ uptake. J. Biol. Chem. 280(20), 19902-19910 (2005)
29. C.T. Lee, S. Shang, L.W. Lai, K.C. Yong, Y.H. Lien, Effect of thiazide on renal gene expression of apical calcium channels and calbindins. Am. J. Physiol. Renal Physiol. 287(6), F1164-F1170 (2004)
30. M.M. Dvorak, C. De Joussineau, D.H. Carter, T. Pisitkun, M.A. Knepper, G. Gamba et al., Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone. J. Am. Soc. Nephrol. 18(9), 2509-2516 (2007)
31. S. Astner R.R. Anderson, Skin phototypes (2003). J. Invest. Dermatol. 122(2), xxx-xxxi (2004)
32. S.V. Giannelli, K.V. Patel, B.G. Windham, F. Pizzarelli, L. Ferrucci, J.M. Guralnik, Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine. J. Am. Geriatr. Soc. 55(6), 816-823 (2007)