Novel buccal adhesive tablets using Aloe vera L and Sinapis alba - A promising option for improved bioavailability of diltiazem hydrochloride

PDA Journal of Pharmaceutical Science and Technology

Volumn 62, Issue 2, 2008, Pages 97-110

  Sudhakar, Yajaman ^a   Bandyopadhyay, A K ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Aloe vera; Buccal; Diltiazem; Mucoadhesive; Pharmacokinetics; Sinapis alba

Indexed keywords

DILTIAZEM; DRUG ADDITIVE; METHANOL; MUSTARD MUCILAGE; UNCLASSIFIED DRUG; ACRYLIC ACID DERIVATIVE; ADHESIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBOMER; DRUG DERIVATIVE; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE;

ALOE VERA; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CHEEK MUCOSA; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; EX VIVO STUDY; HISTOPATHOLOGY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RABBIT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SHEAR STRENGTH; SINAPIS; SWINE; TABLET FORMULATION; TENSILE STRENGTH; TIME TO MAXIMUM PLASMA CONCENTRATION; ADHESION; ADOLESCENT; ADULT; ALOE; ANIMAL; BUCCAL DRUG ADMINISTRATION; CHEMISTRY; COMPARATIVE STUDY; GOAT; HUMAN; METABOLISM; MOUTH MUCOSA; PERMEABILITY; SALIVA; TABLET;

ACRYLATES; ADHESIVENESS; ADHESIVES; ADMINISTRATION, BUCCAL; ADOLESCENT; ADULT; ALOE; ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; EXCIPIENTS; GOATS; HUMANS; MALE; METHYLCELLULOSE; MOUTH MUCOSA; PERMEABILITY; RABBITS; SALIVA; SINAPIS; SWINE; TABLETS;

EID: 45949109249     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Khanna, R.; Agarwal, S. P.; Ahuja, A. Mucoadhesive buccal drug delivery - A potential alternative to conventional therapy. Indian J. Pharm. Sci. 1998, 60, 1-11.
2. Sudhakar, Y.; Kuotsu, K.; Bandyopadhyay, A. K. Buccal bioadhesive drug delivery - A promising option for orally less efficient drugs. J. Controlled Release 2006, 114, 15-40.
3. Balke, D. T.; Diosady, L. L. Rapid aqueous extraction of mucilage from whole white mustard seed. Food Research International 2000, 33, 347-356.
4. Eskin, N. A. M. Effect of variety and geographical location of the incidence of mucilage in canola seeds. Canadian J. Plant Sci. 1992, 72, 1223-1225.
5. Farkas, A. Polysaccharide Product Derived from the Juice of the Aloe Plant and Methods for Preparing Same. U.S. Patent 3,362,951, 1968.
6. Gjerstad, G. An appraisal of the Aloe vera juice. College of Pharmacy, University of Texas, Austin. 1969, 84, 43-46.
7. Ashleye, A. D. Applying heat during processing of the commercial Aloe vera gel. Erde International 1983, 1, 40-44.
8. Train, D. Some aspects of the property of angle of repose of powders. J. Pharm. Pharmacol. 1958, 10, 127T-134T.
9. Barber, T. A. Pharmaceutical Particulate Matter. In Analysis and Control; Interpharm Press: Buffalo Grove, IL, 1993; pp 266-349.
10. Lee, J. W.; Park, J. H.; Robinson, J. R. Bioadhesive based dosage forms: the next generation. J. Pharm. Sci. 2000, 89, 850-866.
11. Duchene, D.; Touchard, F.; Peppas, N. A. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 1998, 14, 283-318.
12. Nafee, N. A.; Ismail, F. A.; Boraie, N. A.; Mortada, L. M. Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation. Drug Dev. Ind. Pharm. 2004, 30, 985-993.
13. Yong, C. S.; Jung, J. H.; Rhee, J. D.; Kim, C. K.; Choi, H. G. Physicochemical characterization and evaluation of buccal bioadhesive tablets containing omeprazole. Drug Dev. Ind. Pharm. 2001, 27, 447-455.
14. Smart, J. D. Drug delivery using buccal adhesive systems. Adv. Drug Delivery Rev. 1993, 11, 253-270.
15. Spiegeleer, B. D.; Vooren, L. V.; Voorspoels, J.; Thone, D.; Rosier, J. Dissolution stability and IVIVC investigation of a buccal tablet. Anal. Chim. Acta 2001, 446, 345-351.
16. Desai, H.; Pramod Kumar, T. M.; Goud, K. Preparation and evaluation of a novel buccal adhesive system. AAPS PharmSciTech 2004, 5, Article 35.
17. Lumb, W. V.; Jones, E. W. Veterinary Anesthesia. In Methods and Equipment for Administration of Inhalation Anesthetics; Lea and Febiger: Philadelphia, PA, 1984; p 265.
18. Kohn, D. F., Wixson, S. K., White, W. J., Benson, G. J., Eds. Anesthesia and Analgesia in Laboratory Animals; Academic Press: New York, 1997.
19. Pablo, A.; Quiroga, M.; Yuln, G. V.; Palummo, M.; Cingolani, A.; Dall, L. L.; Volonte, M. G. Comparative bioavailabilty of Diltiazem in prolonged-release oral preparations. Drug Dev. Ind. Pharm. 2001, 27, 1099-1106.
20. Notari, R. E. Biopharmaceutics and Clinical Pharmacokinetics, 4th ed.; Dekker: New York, 1987.
21. Ritschel, W. A. Bioavailability and bioequivalence. In Ritschel, W. A., Ed. Handbook of Basic Pharmacokinetics, 4th ed.; Drug Intelligence Publications: Hamilton, IL, 1992; pp 493-526.
22. Boxenbaum, H. Pharmacokinetics tricks and traps: flip-flop models. J. Pharm. Pharmaceut. Sci. 1998, 3, 90-91.
23. Snedecor, G. W.; Cochrun, W. G. Statistical Methods Applied to Experiments in Agriculture and Biology, 5th ed.; Iowa State University Press: Ames, IA, 1956.
24. Bailey, K. Cress seed mucilage. Biochemistry Journal 1935, 29, 2477-2485.
25. Cui, W. Mustard as a neutraceutical. Canadian Chemical News 1997, 49, 20-25.
26. Cui, W.; Eskin, N. A. M.; Biliaderis, C. G. Chemical and physical properties of white Mustard (Sinapis alba L). Mucilage Food Chemistry 1993, 46, 169-176.
27. Sharafabadi, S. K. Pseudoplastic Yellow Mustard Gum. U.S. Patent 4,980,186, 1990.
28. Cui, W.; Eskin, N. A. M.; Biliaderis, C. G. Water-soluble white mustard (Sinapis alba L) polysaccharides: partial characterization, molecular size distribution and rheological properties. Carbohydrate Polymers 1993, 40, 215-225.
29. Cui, W.; Eskin, N. A. M.; Biliaderis, C. G.; Marat, K. NMR characterization of a 4-O-methy-β-D-glucuronicacid-containing rhamnogalacturonan from whitemustard (sinapis alba L.) mucilage. Carbohydrate Research 1996, 292, 173-183.
30. Mortazavi, S. A.; Smart, J. D. An in-vitro method for assessing the duration of mucoadhesion. J. Controlled Release 1994, 31, 207-212.
31. Rubel, B. L. Possible mechanisms of the healing actions of Aloe gel. Cosmetics and Toiletries 1983, 98, 109-114.
32. Sheets, M. A. Studies of the effect of acemannon on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats. Veterinary Microbiology 1991, 3, 41-45.
33. Pulse, T. L.; Uhlig, E. A significant improvement in a clinical pilot study utilizing nutritional supplements, essential fatty acids and stabilized Aloe vera juice in 29 HIV seropositive, ARC and AIDS patients. Journal of Advancement in Medicine 1990, 3, 209-230.
34. Bradley, P. R., Ed. British Herbal Compendium; British Herbal Medicine Association: Dorset, U.K., 1992; p 1.
35. Landin, M.; Martinez-Pacheco, R.; Gomez-Amoza, J. L.; Souto, C.; Concheiro, A.; Rowe, R. C. Effect of batch variation and source of pulp on the properties of microcrystalline cellulose. Int. J. Pharm. 1993, 91, 133-141.
36. Staniforth, J. N. Powder Flow. In Pharmaceutics - The Science of Dosage Form Design; Aulton, M. E., Ed.; Churchill Livingston: London, 1996; pp 600-615.
37. Li, K.; Zhang, X.; Zhao, F. HPLC determination of diltiazem in human plasma and its application to pharmacokinetics in humans. Biomed. Chromatogr. 2003, 17, 522-525.