Anti-cofactor autoantibodies in systemic lupus erythematosus: Prevalence, clinical and HLA class II associations

Immunological Investigations

Volumn 37, Issue 4, 2008, Pages 375-385

  Sebastiani, Gian Domenico ^a   Morozzi, Gabriella ^b,h   Bellisai, Francesca ^b   Fineschi, Irene ^b   Bacarelli, Maria Romana ^b   Simpatico, Antonella ^b   Font, Josep ^c   Cervera, Ricard ^c   Houssiau, Frederic ^d   Fernandez Nebro, Antonio ^e   De Ramon Garrido, Enrique ^e   De Pità, Ornella ^f   Smolen, Josef ^g   Galeazzi, Mauro ^b  

^a SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c HOSPITAL CLÍNIC   (Spain)

^d CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^e HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^f LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^g GENERAL HOSPITAL LINZ   (Austria)

^h UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

Anti cofactor antibodies; APL; HLA; SLE

Indexed keywords

ANNEXIN V ANTIBODY; AUTOANTIBODY; HLA A11 ANTIGEN; HLA DPB1 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HLA DR5 ANTIGEN; PROTEIN C ANTIBODY; PROTEIN S ANTIBODY; PROTHROMBIN ANTIBODY;

ADULT; ALLELE; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; HEMOLYTIC ANEMIA; HETEROZYGOSITY; HUMAN; LIVEDO RETICULARIS; MALE; MIGRAINE; MOLECULAR TYPING; PRIORITY JOURNAL; RAYNAUD PHENOMENON; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; THROMBOSIS;

EID: 45949088068     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130802116117     Document Type: Article

References (24)

1. Arnold, J., Holmes, Z., Pickering, W., et al. (2001). Anti-beta 2 glycoprotein 1 and antiannexin V antibodies in women with recurrent miscarriage. Br. J. Haematol. 113:911-914.
2. Berard, M., Chantome, R., Marcelli, A., et al. (1996). Antiphosphatidylethanolamine antibodies as the only antiphospholipid antibodies. I. Association with thrombosis and vascular cutaneous diseases. J. Rheumatol. 23:1369-1374.
3. Bertolaccini, M. L., Atsumi, T., Caliz, A. R., et al. (2000). Association of antiphosphatidylserine/prothrombin autoantibodies with HLA class II genes. Arthritis Rheum. 43:683-688.
4. Bertolaccini, M. L., Atsumi, T., Koike, T., et al. (2005). Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus. Thromb. Haemost. 93:289-297.
5. Bizzaro, N., Tonutti, E., Villalta, D., et al. (2005). Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages. Arch. Pathol. Lab. Med. 129:61-68.
6. Cabiedes, J., Cabral, A. R., Alarcon-Segovia, D. (1995). Clinical manifestations of the antiphospholipid syndrome in patients with systemic lupus erythematosus associate more strongly with anti-beta2-glycoprotein-I than with antiphospholipid antibodies. J. Rheumatol. 22:1899-1906.
7. Fleck, R. A., Rapaport, S. I., Rao, L. V. M. (1988). Antiprothrombin antibodies and the lupus anticoagulant. Blood 72:512-519.
8. Galeazzi, M., Sebastiani, G. D., Tincani, A., et al. (2000). HLA class II associations of anticardiolipin and anti-β2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus 9:47-55.
9. Genetic diversity of HLA functional and medical implications. Proceedings of XII Histocompatibility Workshop and Conference. In: Dominique Charron (Ed.) HLA EDK 1997, I:496.
10. Harris, E. N., Gharavi, A. E., Boey, M. L., et al. (1983). Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 2:1211-1214.
11. Hochberg (1997). Updating the American College of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arth. Rheum. 40: 1725.
12. Horkko, S., Miller, E., Dudi, E., et al. (1996). Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. J. Clin. Invest. 98:815-825.
13. Kimura, A., Sasazuki, T. (1992). Eleventh International Histocompatibility Workshop reference protocol for the HLA-DNA typing technique. In: Tsuji, K., Aizawa, M., Sasazuki, T. (eds.) HLA 1991. Oxford: Oxford University Press; pp. 397-419.
14. Lakos, G., Kiss, E., Regeczy, N., et al. (2000). Antiprothrombin and antiannexin V antibodies imply risk of thrombosis in patients with systemic autoimmune diseases. J. Rheumatol. 27:924-929.
15. Levine, J. S., Branch, D. W., Rauch, J. (2002). The antiphospholipid syndrome. N. Engl. J. Med. 346:752-763.
16. Matsubayashi, H., Arai, T., Izumi, S., et al. (2001). Anti-annexin V antibodies in patients with early pregnancy loss or implantation failures. Fertil. Steril. 76: 694-699.
17. Matsuda, J., Saitoh, N., Gohchi, K., et al. (1994) Anti-annexin V antibody in systemic lupus erythematosus patients with lupus anticoagulant and/or anticardiolipin antibody. Am. J. Hematol. 47:56-58.
18. Roubey, R. A. S. (1996). Immunology of the antiphospholipid antibody syndrome. Arthritis Rheum. 39:1444-1454.
19. Sahin, M., Duzgun, N., Tunc, S. E., et al. (2007). Clinical manifestations and antiphosphatidylserine antibodies in patients with systemic lupus erythematosus: is there an association? Clin. Rheumatol. 26:154-160
20. Sebastiani, G. D., Minisola, G., Galeazzi, M. (2003). HLA class II alleles and genetic predisposition to the antiphospholipid syndrome. Autoimmun. Rev. 2:387-394.
21. Sebastiani, G. D., Galeazzi, M., Morozzi, G. (2002). Immunogenetics of the antiphospholipid syndrome. In: Asherson, R. A., et al. (eds.), "The Antiphospholipid Syndrome II - Autoimmune Thrombosis", Elsevier: Oxford, pp. 119-129.
22. Sebastiani, G. D., Galeazzi, M., Tincani, A., et al. (2003). HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus 12:560-563.
23. Tarr, T., Lakos, G., Bhattoa, H. P., Soltesz, P., Shoenfeld, Y., Szegedi, G., Kiss, E. (2007). Clinical thrombotic manifestations in SLE patients with and without antiphospholipid antibodies: a 5-year follow-up. Clin. Rev. Allergy Immunol. 32:131-137.
24. Viard, J., Amoura, Z., Bach, J. (1992). Association of anti-beta2-glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am. J. Med. 93:181-186.