Identification and characterization of HLA-B*5401-restricted HIV-1-Nef and Pol-specific CTL epitopes

Microbes and Infection

Volumn 10, Issue 7, 2008, Pages 764-772

  Kitano, Mitsutaka ^a   Kobayashi, Naoki ^a   Kawashima, Yuka ^a   Akahoshi, Tomohiro ^a   Nokihara, Kiyoshi ^c   Oka, Shinichi ^a,b   Takighuchi, Masafumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c HiPep Laboratories   (Japan)

Author keywords

Cytotoxic T lymphocytes; Epitopes; HIV 1

Indexed keywords

EPITOPE; GAG PROTEIN; HLA B ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEF PROTEIN; POL PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLELE; ANTIGEN PRESENTATION; ARTICLE; ASIA; CD8+ T LYMPHOCYTE; CELL KILLING; CYTOTOXIC T LYMPHOCYTE; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS RECOMBINANT;

ASIA; B-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPE MAPPING; EPITOPES; HIV-1; HLA-B ANTIGENS; HUMANS; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1; VACCINIA VIRUS;

EID: 45849154228     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2008.04.006     Document Type: Article

References (31)

1. Koup R.A., Safrit J.T., Cao Y., Andrews C.A., McLeod G., Borkowsky W., Farthing C., and Ho D.D. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68 (1994) 4650-4655
2. Pantaleo G., Demarest J.F., Soudeyns H., Graziosi C., Denis F., Adelsberger J.W., Borrow P., Saag M.S., Shaw G.M., Sekaly P.S., and Fauci A.S. Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV. Nature 370 (1994) 463-467
3. Moss P.A., Rowland-Jones S.L., Frodsham P.M., McAdam S., Giangrande P., McMichael A.J., and Bell J. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc. Natl. Acad. Sci. U. S. A. 192 (1995) 5773-5777
4. Rowland-Jones S., Sutton J., Ariyoshi K., Dong T., Gotch F., McAdam S., Whitby D., Sabally S., Gallimore A., Corrah T., Takiguchi M., Schultz T., McMichael A., and Whittle H. HIV-1 specific cytotoxic T cells in HIV-exposed but uninfected Gambian women. Nat. Med. 1 (1995) 59-64
5. Walker C.M., Moody D.J., Stites D.P., and Levy J.A. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234 (1986) 1563-1566
6. Yang O.O., and Walker B.D. CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication. Adv. Immunol. 66 (1997) 273-311
7. Matano T., Shibata R., Siemon C., Connors M., Lane H.C., and Martin M.A. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72 (1998) 164-169
8. Borrow P., Lewicki H., Wei X., Horwitz M.S., Peffer N., Meyers H., Nelson J.A., Gairin J.E., Hahn B.H., Oldstone M.B., and Shaw G.M. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3 (1997) 205-211
9. Goulder P.J., Philips R.E., Colbert R.A., McAdam S., Ogg G., Nowak M.A., Giangrande P., Luzzi G., Morgan B., Edwards A., McMichael A.J., and Rowland-Jones S. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3 (1997) 212-217
10. Frater A.J., Brown H., Oxenius A., Günthard H.F., Hirschel B., Robinson N., Leslie A.J., Payne R., Crawford H., Prendergast A., Brander C., Kiepiela P., Walker B.D., Goulder P.J., McLean A., and Phillips R.E. Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression. J. Virol. 81 (2007) 6742-6751
11. O'Brien S.J., Gao X., and Carrington M. HLA and AIDS: a cautionary tale. Trends Mol. Med. 7 (2001) 379-381
12. Altfeld M., Kalife E.T., Qi Y., Streeck H., Lichterfeld M., Johnston M.N., Burgett N., Swartz M.E., Yang A., Alter G., Yu X.G., Meier A., Rockstroh J.K., Allen T.M., Jessen H., Rosenberg E.S., Carrington M., and Walker B.D. HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T cell response against HIV-1. PLoS Med. 3 (2006) e403
13. Ikeda-Moore Y., Tomiyama H., Miwa K., Oka S., Iwamoto A., Kaneko Y., and Takiguchi M. Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1. J. Immunol. 159 (1997) 6242-6252
14. Fukada K., Tomiyama H., Chujoh Y., Miwa K., Kaneko Y., Oka S., and Takiguchi M. HLA-A*1101-restricted cytotoxic T lymphocyte recognition for a novel epitope derived from the HIV-1 Env protein. AIDS 13 (1999) 2597-2599
15. Tomiyama H., Sakaguchi T., Miwa K., Oka S., Iwamoto A., Kaneko Y., and Takiguchi M. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101 molecules. Hum. Immunol. 60 (1999) 177-186
16. Hossain M.S., Tomiyama H., Inagawa T., Ida S., Oka S., and Takiguchi M. Identification and characterization of HLA-A*3303-restricted, HIV type 1 Pol- and Gag-derived cytotoxic T cell epitopes. AIDS Res. Hum. Retroviruses 19 (2003) 503-510
17. Satoh M., Takamiya Y., Oka S., Tokunaga K., and Takiguchi M. Identification and characterization of HIV-1-specific CD8+ T cell epitopes presented by HLA-A*2601. Vaccine 23 (2005) 3783-3790
18. Kawashima Y., Satoh M., Oka S., and Takiguchi M. Identification and characterization of HIV-1 epitopes presented by HLA-A*2603: comparison between HIV-1 epitopes presented by A*2601 and A*2603. Hum. Immunol. 66 (2005) 1155-1166
19. Borghan M.A., Oka S., and Takiguchi M. Identification of HLA-A*3101-restricted cytotoxic T-lymphocyte response to human immunodeficiency virus type 1 (HIV-1) in patients with chronic HIV-1 infection. Tissue Antigens 66 (2005) 305-313
20. Dong T., Boyd D., Rosenberg W., Alp N., Takiguchi M., McMichael A., and Rowland-Jones S. An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide. Eur. J. Immunol. 26 (1996) 335-339
21. Goulder P.J., Reid S.W., Price D.A., O'Callaghan C.A., McMichael A.J., Phillips R.E., and Jones E.Y. Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes. Eur. J. Immunol. 27 (1997) 1515-1521
22. Altfeld M., Addo M.M., Eldridge R.L., Yu X.G., Thomas S., Khatri A., Strick D., Phillips M.N., Cohen G.B., Islam S.A., Kalams S.A., Brander C., Goulder P.J., Rosenberg E.S., Walker B.D., and HIV Study Collaboration. Vpr is preferentially targeted by CTL during HIV-1 infection. J. Immunol. 167 (2001) 2743-2752
23. Addo M.M., Altfeld M., Rosenberg E.S., Eldridge R.L., Philips M.N., Habeeb K., Khatri A., Brander C., Robbins G.K., Mazzara G.P., Goulder P.J., Walker B.D., and HIV Controller Study Collaboration. The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1781-1786
24. Goulder P.J., Addo M.M., Altfeld M.A., Rosenberg E.S., Tang Y., Govender U., Mngqundaniso N., Annamalai K., Vogel T.U., Hammond M., Bunce M., Coovadia H.M., and Walker B.D. Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays. J. Virol 75 (2001) 1339-1347
25. Draenert R., Altfeld M., Brander C., Basgoz N., Corcoran C., Wurcel A.G., Stone D.R., Kalams S.A., Trocha A., Addo M.M., Goulder P.J., and Walker B.D. Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses. J. Immunol. Methods 275 (2003) 19-29
26. Maecker H.T., Dunn H.S., Suni M.A., Khatamzas E., Pitcher C.J., Bunde T., Persaud N., Trigona W., Fu T.M., Sinclair E., Bredt B.M., McCune J.M., Maino V.C., Kern F., and Picker L.J. Use of overlapping peptide mixtures as antigens for cytokine flow cytometry. J. Immunol. Methods 255 (2001) 27-40
27. Imanishi T., Akaza T., Kimura A., Tokunaga K., and Gojobori T. In: Tsuji K., Aizava M., and Sasazuki T. (Eds). Allele and Haplotype Frequencies for HLA and Complement Loci in Various Ethnic Groups, HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference (1992), Oxford University Press, Oxford
28. Blagoveshchenskaya A.D., Thomas L., Feliciangeli S.F., Hung C.-H., and Thomas G. HIV-1 Nef downregulates MHC-1 by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell 111 (2002) 853-866
29. Barber L.D., Gillece-Castro B., Percival L., Li X., Clayberger C., and Parham P. Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes. Curr. Biol. 1 (1995) 179-190
30. Yewdell J.W., and Bennink J.R. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 17 (1999) 51-88
31. Kiepiela P., Ngumbela K., Thobakgale C., Ramduth D., Honeyborne I., Moodley E., Reddy S., de Pierres C., Mncube Z., Mkhwanazi N., Bishop K., van der Stok M., Nair K., Khan N., Crawford H., Payne R., Leslie A., Prado J., Prendergast A., Frater J., McCarthy N., Brander C., Learn G.H., Nickle D., Rousseau C., Coovadia H., Mullins J.I., Heckerman D., Walker B.D., and Goulder P. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13 (2007) 46-53