Death of a female addict due to heroin and cocaine overdoses: A case report with multiparameter evaluation

Forensic Toxicology

Volumn 26, Issue 1, 2008, Pages 36-40

  Kłys, Małgorzata ^a   Rojek, Sebastian ^a   Kowalski, Piotr ^a   Rzepecka Woźniak, Ewa ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Cocaine; Hair analysis; Heroin; LC APCI MS MS; Morphine glucuronides; Multiparameter evaluation

Indexed keywords

BENZOYLECGONINE; COCAINE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 ACETATE; MORPHINE 6 GLUCURONIDE;

ADULT; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CASE REPORT; COCAINE DEPENDENCE; DRUG OVERDOSE; FATALITY; FEMALE; FORENSIC TOXICOLOGY; HAIR ANALYSIS; HEROIN DEPENDENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 45849149242     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-008-0042-1     Document Type: Article

References (20)

1. Preti A, Miotto P, De Coppi M (2002) Deaths by unintentional illicit drug overdose in Italy, 1984-2000. Drug Alcohol Depend 66:275-282
2. Darke S, Zador D (1996) Fatal heroin "overdose". Addiction 91:1765-1772
3. White JM, Irvine RJ (1999) Mechanisms of fatal opioid overdose. Addiction 94:961-972
4. Coffin PO, Galea S, Ahern J, Leon AC, Vlahov D, Tardiff K (2003) Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98. Addiction 98:739-747
5. Marzuk PM, Tardiff K, Leon AC, Hirsch CS, Stajic M, Pertera L, Hartwell N (1997) Poverty and fatal accidental drug overdoses of cocaine and opiates in New York City: an ecological study. Am J Drug Alcohol Abuse 23:221-228
6. Kronstrand R, Grundin R, Jonsson J (1998) Incidence of opiates, amphetamines, and cocaine in hair and blood in fatal cases of heroin overdose. Forensic Sci Int 92:29-38
7. Lachenmeier K, Musshoff F, Madea B (2006) Determination of opiates and cocaine in hair using automated enzyme immunoassay screening methodologies followed by gas chromatographic-mass spectrometric (GC-MS) confirmation. Forensic Sci Int 159:188-199
8. Torralba L, Brugal MT, Villalbi JR, Tortosa MT, Toribio A, Valverde JL (1996) Mortality due to acute adverse drug reactions: opiates and cocaine in Barcelona, 1989-93. Addiction 91:419-426
9. Kłys M, Bystrowska B, Bujak-Giżycka B, Nowak G (2001) Significance of toxic interactions in medicolegal evidence. Complex fatal poisonings with drugs of abuse in the material of the Chair of Forensic Medicine, Collegium Medicum Jagiellonian University in Kraków. Pol J Pharmacol 53:653-658
10. Kłys M, Rojek S, Kulikowska J, Bożek E, Ścisł owski M (2005) Usefulness of multiparameter opiate analysis in hair of drug users and victims of fatal poisonings. Przegl Lek 62:595-590
11. Kłys M, Rojek S, Kulikowska J, Bożek E, Ścisł owski M (2007) Usefulness of multi-parameter opiate analysis in hair of drug users for the evaluation of an abuse profile by means of tandem LC-APCI-MS-MS. J Chromatogr B 854:299-307
12. Kłys M, Rojek S, Kulikowska J, Bożek E (2007) Usefulness of multiparameter opiate and amphetamine analysis of hair segments under methadone therapy using LC-APCI-MS-MS. Forensic Toxicol 25:69-75
13. Baselt RC (2000) Disposition of toxic drugs and chemicals in man, 5th edn. Chemical Toxicology Institute, Foster City, pp 407-412
14. Winek CL, Wahba WW, Winek CL Jr, Balzer TW (2001) Drug and chemical blood-level data 2001. Forensic Sci Int 122:107-123
15. Uges DRA (1996) Therapeutic and toxic drug concentrations. Bull Int Assoc Forensic Toxicol 26:1-34
16. Bogusz MJ, Maier RD, Erkens M, Driessen S (1997) Determination of morphine and 3-and 6-glucuronides, codeine, codeine-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography atmospheric pressure chemical ionization mass spectrometry. J Chromatogr B 703:115-127
17. Bogusz MJ, Maier RD, Driessen S (1997) Morphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacethylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims. J Anal Toxicol 21:346-355
18. Aderjan R, Hofmann S, Schmitt G, Skopp G (1995) Morphine and morphine glucuronides in serum of heroin consumers and heroin-related deaths determined by HPLC with native fluorescence detection. J Anal Toxicol 19:163-168
19. Goldberger BA, Cone EJ, Grant TM, Caplan YK, Levine BS, Smialek JL (1994) Disposition of heroin and its metabolites in heroin-related deaths. J Anal Toxicol 18:22-28
20. Spieler VR, Reed D (1985) Brain concentrations of cocaine and benzoylecgonine in fatal cases. J Forensic Sci 30:1003-1011