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Volumn 10, Issue 7, 2008, Pages 1417-1420

An efficient method to convert lactams and amides into 2,2-dialkylated amines

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; LACTAM;

EID: 45849147386     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol800145h     Document Type: Article
Times cited : (41)

References (21)
  • 1
    • 33644950838 scopus 로고    scopus 로고
    • For a recent review on the synthesis of 1-azaspirocycles, see
    • For a recent review on the synthesis of 1-azaspirocycles, see: Dake, G. Tetrahedron 2006, 62, 3467-3492.
    • (2006) Tetrahedron , vol.62 , pp. 3467-3492
    • Dake, G.1
  • 6
    • 0037167070 scopus 로고    scopus 로고
    • Li, Z.; Zhang, Y. Tetrahedron 2002, 58 (26), 5301-5306.
    • (2002) Tetrahedron , vol.58 , Issue.26 , pp. 5301-5306
    • Li, Z.1    Zhang, Y.2
  • 14
    • 59849120438 scopus 로고    scopus 로고
    • All our attempts to apply Klaver's procedure to monocyclic thioiminium salts bearing acidic H-atoms, such as 3a, failed to give the expected monoalkylated or dialkylated products due to competitive deprotonation of the thioiminium salts.
    • All our attempts to apply Klaver's procedure to monocyclic thioiminium salts bearing acidic H-atoms, such as 3a, failed to give the expected monoalkylated or dialkylated products due to competitive deprotonation of the thioiminium salts.
  • 16
    • 0037424287 scopus 로고    scopus 로고
    • Recently, the monoalkylation of thioiminium ion with alkylcuprates has been reported by Amat et al.: Amat, M.; Llor, N.; Hidalgo, J.; Escolano, C.; Bosch, J. J. Org. Chem. 2003, 68, 1919-1928.
    • Recently, the monoalkylation of thioiminium ion with alkylcuprates has been reported by Amat et al.: Amat, M.; Llor, N.; Hidalgo, J.; Escolano, C.; Bosch, J. J. Org. Chem. 2003, 68, 1919-1928.
  • 17
    • 33947350302 scopus 로고    scopus 로고
    • Direct reaction of secondary amines with tert-butyl halides did not afford the tert-butyl amines in useful yields: Drake, W. V.; McElvain, S. M. J. Am. Chem. Soc. 1933, 55, 1155-1158.
    • Direct reaction of secondary amines with tert-butyl halides did not afford the tert-butyl amines in useful yields: Drake, W. V.; McElvain, S. M. J. Am. Chem. Soc. 1933, 55, 1155-1158.
  • 18
    • 78651150322 scopus 로고    scopus 로고
    • For examples of multistep tert-butylation of a secondary amines, see: Knabe, J, Grund, G. Arch. Pharm. 1963, 296, 820-828
    • For examples of multistep tert-butylation of a secondary amines, see: Knabe, J.; Grund, G. Arch. Pharm. 1963, 296, 820-828.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.