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All our attempts to apply Klaver's procedure to monocyclic thioiminium salts bearing acidic H-atoms, such as 3a, failed to give the expected monoalkylated or dialkylated products due to competitive deprotonation of the thioiminium salts.
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All our attempts to apply Klaver's procedure to monocyclic thioiminium salts bearing acidic H-atoms, such as 3a, failed to give the expected monoalkylated or dialkylated products due to competitive deprotonation of the thioiminium salts.
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For examples of multistep tert-butylation of a secondary amines, see: Knabe, J.; Grund, G. Arch. Pharm. 1963, 296, 820-828.
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