Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial

Fertility and Sterility

Volumn 90, Issue 1, 2008, Pages 113-120

  Lee, Tsung Hsien ^a,b,c   Lin, Yu Hung ^d,e   Seow, Kok Min ^d   Hwang, Jiann Loung ^d,e,f   Tzeng, Chii Ruey ^f   Yang, Yu Shih ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aromatase inhibitor; GnRH antagonist; ovulation induction; pregnancy; premature LH surge

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; GONADORELIN ANTAGONIST; GONADOTROPIN DERIVATIVE; LETROZOLE; LUTEINIZING HORMONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CELL STIMULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRAUTERINE INSEMINATION; MAJOR CLINICAL STUDY; OVARY CELL CULTURE; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; UNIVERSITY HOSPITAL;

ADULT; AROMATASE INHIBITORS; CHORIONIC GONADOTROPIN; DRUG THERAPY, COMBINATION; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HORMONE ANTAGONISTS; HUMANS; INFERTILITY; LUTEINIZING HORMONE; NITRILES; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TAIWAN; TREATMENT OUTCOME; TRIAZOLES; UP-REGULATION;

EID: 45849141630     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.06.029     Document Type: Article

References (25)

1. Dodson W.C., Whitesides D.B., Hughes Jr. C.L., Easley III H.A., and Haney A.F. Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertil Steril 48 (1987) 441-445
2. Guzick D.S., Carson S.A., Coutifaris C., Overstreet J.W., Factor-Litvak P., Steinkampf M.P., et al. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network. N Engl J Med 340 (1999) 177-183
3. Gonen Y., and Casper R.F. Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth. Hum Reprod 5 (1990) 670-674
4. Goswami S.K., Das T., Chattopadhyay R., Sawhney V., Kumar J., Chaudhury K., et al. A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Hum Reprod 19 (2004) 2031-2035
5. Mitwally M.F., and Casper R.F. Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility. Hum Reprod 18 (2003) 1588-1597
6. Casper R.F., and Mitwally M.F. Review: aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab 91 (2006) 760-771
7. Mitwally M.F., Abdel-Razeq S., and Casper R.F. Human chorionic gonadotropin administration is associated with high pregnancy rates during ovarian stimulation and timed intercourse or intrauterine insemination. Reprod Biol Endocrinol 2 (2004) 55
8. Fatemi H.M., Kolibianakis E., Tournaye H., Camus M., Van Steirteghem A.C., and Devroey P. Clomiphene citrate versus letrozole for ovarian stimulation: a pilot study. Reprod Biomed Online 7 (2003) 543-546
9. Mitwally M.F., and Casper R.F. LH surge is associated with higher LH levels and more physiologic estradiol levels in aromatase inhibitor ovarian stimulation cycles. [abstract]. Fertil Steril 82 Suppl 2 (2004) S144
10. Engel J.B., Ludwig M., Felberbaum R., Albano C., Devroey P., and Diedrich K. Use of cetrorelix in combination with clomiphene citrate and gonadotrophins: a suitable approach to "friendly IVF"?. Hum Reprod 17 (2002) 2022-2026
11. Garcia-Velasco J.A., Moreno L., Pacheco A., Guillen A., Duque L., Requena A., et al. The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study. Fertil Steril 84 (2005) 82-87
12. Olivennes F., Belaisch-Allart J., Emperaire J.C., Dechaud H., Alvarez S., Moreau L., et al. Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin). Fertil Steril 73 (2000) 314-320
13. Al Inany H., and Aboulghar M. GnRH antagonist in assisted reproduction: a Cochrane review. Hum Reprod 17 (2002) 874-885
14. Lossl K., Andersen A.N., Loft A., Freiesleben N.L., Bangsboll S., and Andersen C.Y. Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols. Hum Reprod 21 (2006) 2593-2600
15. Weil S.J., Vendola K., Zhou J., Adesanya O.O., Wang J., Okafor J., et al. Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations. J Clin Endocrinol Metab 83 (1998) 2479-2485
16. Vendola K., Zhou J., Wang J., Famuyiwa O.A., Bievre M., and Bondy C.A. Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary. Biol Reprod 61 (1999) 353-357
17. Fraser H.M., Groome N.P., and McNeilly A.S. Follicle-stimulating hormone-inhibin B interactions during the follicular phase of the primate menstrual cycle revealed by gonadotropin-releasing hormone antagonist and antiestrogen treatment. J Clin Endocrinol Metab 84 (1999) 1365-1369
18. Erickson G.F., Wang C., and Hsueh A.J. FSH induction of functional LH receptors in granulosa cells cultured in a chemically defined medium. Nature 279 (1979) 336-338
19. Al Inany H., Aboulghar M.A., Mansour R.T., and Serour G.I. Optimizing GnRH antagonist administration: meta-analysis of fixed versus flexible protocol. Reprod Biomed Online 10 (2005) 567-570
20. Hwang J.L., Huang L.W., Hsieh B.C., Tsai Y.L., Huang S.C., Chen C.Y., et al. Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles. Hum Reprod 18 (2003) 45-49
21. Lin Y.H., Hwang J.L., Seow K.M., Huang L.W., Hsieh B.C., and Tzeng C.R. Comparison of outcome of clomiphene citrate/human menopausal gonadotropin/cetrorelix protocol and buserelin long protocol-a randomized study. Gynecol Endocrinol 22 (2006) 297-302
22. Lambalk C.B., Leader A., Olivennes F., Fluker M.R., Andersen A.N., Ingerslev J., et al. Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial. Hum Reprod 21 (2006) 632-639
23. Allegra A., Marino A., Coffaro F., Scaglione P., Sammartano F., Rizza G., et al. GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial. Hum Reprod 22 (2007) 101-108
24. Aboulghar M.A., Mansour R.T., Serour G.I., and Al Inany H.G. Diagnosis and management of unexplained infertility: an update. Arch Gynecol Obstet 267 (2003) 177-188
25. World Health Organization. Temporal relationships between ovulation and defined changes in the concentration of plasma estradiol-17 beta, luteinizing hormone, follicle-stimulating hormone, and progesterone. Am J Obstet Gynecol 138 (1980) 383-390