Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells

Cancer Chemotherapy and Pharmacology

Volumn 62, Issue 3, 2008, Pages 491-498

  Adler, Victor ^a   Bowne, Wilbur ^a,b   Kamran, Ikram ^b   Michl, Josef ^b,c   Friedman, Fred K ^d   Chin, Edwin ^a   Zenilman, Michael ^b   Pincus, Matthew R ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cancer cell lines; Cell transformation; Phenotypic reversion; Ras peptides; Ras p21 protein; Tumor cell necrosis

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CASPASE; INSULIN; LACTATE DEHYDROGENASE; PENETRATIN; PEPTIDE PNC 2; PEPTIDE PNC 7; PROTEIN P21; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ACINAR CELL; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ASTROCYTOMA CELL; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL COUNT; CELL DEATH; CELL LYSATE; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; FEMALE; FIBROSARCOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INHIBITION KINETICS; NONHUMAN; OOCYTE; OOCYTE MATURATION; PANCREAS CANCER; PRIORITY JOURNAL; RAT; WILD TYPE;

ANTINEOPLASTIC AGENTS; CASPASES; CELL CULTURE TECHNIQUES; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NECROSIS; ONCOGENE PROTEIN P21(RAS); PEPTIDE FRAGMENTS; PHOSPHORYLATION;

EID: 45849127300     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0630-5     Document Type: Article

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