Determination of cannabinoids in whole blood by UPLC-MS-MS

Journal of Analytical Toxicology

Volumn 32, Issue 5, 2008, Pages 349-354

  Jamey, Carole ^a   Szwarc, Esther ^a   Tracqui, Antoine ^a   Ludes, Bertrand ^a  

^a INSTITUT DE MÉDECINE LÉGALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID;

ARTICLE; BLOOD SAMPLING; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 45849093256     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.5.349     Document Type: Article

References (19)

1. P. Mura, C. Chatelain, V. Dumestre, J.M. Gaulier, M.H. Ghysel, C. Lacroix, M.F. Kergueris, M. Lhermitte, M. Moulsma, G. Pépin, F. Vincent, and P. Kintz. Use of drugs of abuse in less than 30-year-old drivers killed in a road crash in France: a spectacular increase for cannabis, cocaine and amphetamines. Forensic Sci. Int. 160: 168-172 (2006).
2. F. Musshoff and B. Madea. Review of biologic matrices (urines, blood, hair) as indicators of recent or ongoing cannabis use. Ther. Drug Monit. 28: 155-163 (2006).
3. 9- tetrahydrocannabinol in human plasma after controlled oral administration of cannabinoids. Ther. Drug Monit. 28: 545-551 (2006).
4. 9-tetrahydrocannabinol (THCA) in whole blood using two-dimensional gas chromatography and EI-mass spectrometry. J. Anal. Toxicol. 30: 262-266 (2006).
5. T. Nadulski, F. Sporkert, M. Schnelle, A.M. Stadelmann, P. Roser, T. Schefter, and F. Pragst. Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extract. J. Anal. Toxicol. 29: 782-789 (2005).
6. 9- tetrahydrocannabinol (THC), 11-hydroxy-THC and 11-nor-9-carboxy-THC in human plasma using solid phase extraction and gas chromatography-mass spectrometry with positive chemical ionization. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 798: 145-154 (2003).
7. 9-THC in whole blood using gas chromatography-mass spectrometry. J. Anal. Toxicol. 26: 575-581 (2002).
8. 9-THC-COOH in oral fluid, urine and whole blood using solid-phase extraction and liquid chromatography-mass spectrometry with electrospray extraction and liquid chromatography-mass spectrometry with electrospray ionization. Forensic Sci. Int. 170: 148-155 (2007).
9. S.B. Grauwiler, A. Scholer, and J. Drewe. Development of a LC/MS/MS method for the analysis of cannabinoids in human EDTA-plasma and urine after small doses of Cannabis sativa extracts. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 850: 515-522 (2007).
10. 9-tetrahydrocannabinolic acid A in human urine and blood serum by LC-MS/MS. J. Mass. Spectrom. 42: 354-360 (2007).
11. R. Yang and W. Xie. Determination of cannabinoids in biological samples using a new solid phase micro-extraction membrane and liquid chromatography-mass spectrometry. Forensic Sci. Int. 162: 135-139 (2006).
12. 9-tetrahydrocannabinol in human plasma by high performance liquid chromatography after solidphase extraction. J. Pharm. Biomed. Anal. 41: 1011-1016 (2006).
13. 8- THC-9-COOH in plasma. J. Pharm. Biomed. Anal. 38: 112-118 (2005).
14. 9- tetrahydrocannabinol in human plasma by high-performance liquid chromatography/tandem mass spectrometry. J. Mass. Spectrom. 39: 526-531 (2004).
15. M.I. Churchwell, N.C. Twaddle, L.R. Meeker, and D.R. Doerge. Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 825: 134-143 (2005).
16. D.T. Nguyen, D. Guillarme, S. Heinisch, M.P. Barrioulet, J.L. Rocca, S. Rudaz, and J.L. Veuthey. High throughput liquid chromatography with sub-2 microm particles at high pressure and high temperature. J. Chromatogr. A 1167: 76-84 (2007).
17. 9-tetrahydrocannabinol in oral fluid samples using solid-phase extraction and high-performance liquid chromatography-electrospray ionization mass spectrometry. Forensic Sci. Int. 150: 205-211 (2005).
18. B.K. Matuszewski, M.L. Constanzer, and C.M. Chavez-Eng. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75: 3019-3030 (2003).
19. P. Kintz and V. Cirimele. Testing human blood for cannabis by GC-MS. Biomed Chromatogr. 11: 371-373 (1997).