The detection of Δ9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCA) in whole blood using two-dimensional gas chromatography and el-mass spectrometry

Journal of Analytical Toxicology

Volumn 30, Issue 4, 2006, Pages 262-266

  Scurlock, Rodger D ^a   Ohlson, Greg B ^a   Worthen, David K ^a  

^a Toxicology Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; DRONABINOL; TETRAHYDROCANNABINOLIC ACID; TRIMETHYLSILYL DERIVATIVE; 11 NOR DELTA(9) TETRAHYDROCANNABINOL 9 CARBOXYLIC ACID; 11-NOR-DELTA(9)-TETRAHYDROCANNABINOL-9-CARBOXYLIC ACID; DRUG DERIVATIVE; PSYCHOTROPIC AGENT; TETRAHYDROCANNABINOL;

ARTICLE; BLOOD ANALYSIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELUTION; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; BLOOD; EVALUATION; MASS FRAGMENTOGRAPHY; METHODOLOGY; SENSITIVITY AND SPECIFICITY;

FLAME IONIZATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PSYCHOTROPIC DRUGS; SENSITIVITY AND SPECIFICITY; TETRAHYDROCANNABINOL;

EID: 33747198086     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/30.4.262     Document Type: Article

References (9)

1. M.A. Huestis, J.E. Henningfield, and E.J. Cone. Blood cannabinoids I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. J. Anal. Toxicol. 16: 276-282 (1992).
2. 9-tetrahydrocannabinol (THCCOOH). J. Anal. Toxicol. 16: 283-289 (1992).
3. M.A. Peat. Advances in Analytical Toxicology, Vol II, R.C. Baselt, Ed. Yearbook Medical Publishers, Chicago, IL, 1989, pp 186-217.
4. M. Widman, S. Agurell, M. Ehrnebo, and G. Jones. Binding of (±)-and (-)-delta-1-tetrahydrocannabinols and (-)-7-hydroxy-delta-1- tetrahydrocannabinol to blood cells and plasma proteins in man. J. Pharm. Pharmacol. 26: 914-916 (1974).
5. 9- tetrahydrocannabinol in whole blood using solvent extraction combined with polar solid-phase extraction. J. Anal. Toxicol. 24: 127-132 (2000).
6. 9- tetrahydrocannabinol in human plasma by solid-phase extraction and gas chromatography-negative ion chemical ionization-mass spectrometry. J. Anal. Toxicol. 25: 531-537 (2001).
7. R.A. Gustafson, E.T. Moolchan, A. Barns, B. Levine, and M.A. Huestis. Validated method for the simultaneous determination of delta 9-tetrahydrocannabinol (THC), 11-hydroxy-THC and 11-nor-9-carboxy-THC in human plasma using solid phase extraction and gas chromatography-mass spectrometry with positive chemical ionization. J. Chromatogr. B 798(1): 145-154 (2003).
8. S. Niedbala, K. Kardos, S. Salamone, D. Fritch, M. Bronsgeest, and E.J. Cone. Passive cannabis smoke exposure and oral fluid testing. J. Anal. Toxicol. 28: 546-552 (2004).
9. 9-tetrahydrocannabinol and two major metabolites in serum using ion-trap GC-MS-MS. J. Anal. Toxicol. 24: 359-364 (2000).