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Volumn 3, Issue 5, 2008, Pages 335-343

Toxicological evaluation of the anti-malarial herb Cryptolepis sanguinolenta in rodents

Author keywords

Antimalarial; CNS depressant; Cryptolepis sanguinolenta; Haematological parameters; Rodents; Sleeping time

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ANTIMALARIAL AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON MONOXIDE; CENTRAL DEPRESSANT AGENT; CRYPTOLEPIS SANGUINOLENTA EXTRACT; CYTOCHROME P450; GAMMA GLUTAMYLTRANSFERASE; GLOBULIN; HEMOGLOBIN; HYPNOTIC SEDATIVE AGENT; KETOCONAZOLE; PENTOBARBITAL; PLANT EXTRACT;

EID: 45749147106     PISSN: 1816496X     EISSN: None     Source Type: Journal    
DOI: 10.3923/jpt.2008.335.343     Document Type: Article
Times cited : (8)

References (30)
  • 1
    • 0036906337 scopus 로고    scopus 로고
    • The popular herbal antimalarial, extract of Cryptolepis sanguinolenta, is potently cytotoxic
    • Ansah, C. and N.J. Gooderham, 2002. The popular herbal antimalarial, extract of Cryptolepis sanguinolenta, is potently cytotoxic. Toxicol. Sci., 70 (2): 245-251.
    • (2002) Toxicol. Sci , vol.70 , Issue.2 , pp. 245-251
    • Ansah, C.1    Gooderham, N.J.2
  • 2
    • 45749101571 scopus 로고    scopus 로고
    • Reactive oxygert species is associated with cryptolepine cytotoxicity
    • Ansah, C. and N.J Gooderham, 2005. Reactive oxygert species is associated with cryptolepine cytotoxicity. J. Sci. Technol., 25 (1): 1-10.
    • (2005) J. Sci. Technol , vol.25 , Issue.1 , pp. 1-10
    • Ansah, C.1    Gooderham, N.J.2
  • 3
    • 0019424939 scopus 로고
    • Studies on cryptolepine II: Inhibition of carageenan-induced oedema by cryptolepine
    • Bamgbose, S.O.A. and B.K. Noamesi, 1981. Studies on cryptolepine II: Inhibition of carageenan-induced oedema by cryptolepine. Planta Med., 41 (4): 392-396.
    • (1981) Planta Med , vol.41 , Issue.4 , pp. 392-396
    • Bamgbose, S.O.A.1    Noamesi, B.K.2
  • 4
    • 0031908470 scopus 로고    scopus 로고
    • Possible toxicity of herbal medicines
    • Bateman, J., R.D. Chapman and D. Simpson, 1998. Possible toxicity of herbal medicines. Scott-Med. J., 43 (1): 7-15.
    • (1998) Scott-Med. J , vol.43 , Issue.1 , pp. 7-15
    • Bateman, J.1    Chapman, R.D.2    Simpson, D.3
  • 5
    • 14444274095 scopus 로고    scopus 로고
    • Bierer, Dr.E., L.G. Dubenko, P. Zhang, Q. Lu, P.A. Imbach, A.W. Garofalo, P.W. Phuan, D.M. Fort, J. Litvak, R.E.: Gerber, B. Sloan, J. Luo, R. Cooper and G.M. Reaven, 1998. Antihyperglycaemic activities of cryptolepine analogues: An ethnobotanical lead structure isolated from Cryptolepis sanguinolenta. J. Med. Chem., 41 (15): 2754-2764.
    • Bierer, Dr.E., L.G. Dubenko, P. Zhang, Q. Lu, P.A. Imbach, A.W. Garofalo, P.W. Phuan, D.M. Fort, J. Litvak, R.E.: Gerber, B. Sloan, J. Luo, R. Cooper and G.M. Reaven, 1998. Antihyperglycaemic activities of cryptolepine analogues: An ethnobotanical lead structure isolated from Cryptolepis sanguinolenta. J. Med. Chem., 41 (15): 2754-2764.
  • 6
    • 0018631662 scopus 로고
    • Cryptolepine hydrochloride effect on Staphylococcus aureus
    • Boakye Yiadom, K. and S.M. Herman-Ackah, 1979. Cryptolepine hydrochloride effect on Staphylococcus aureus. J. Pharm. Sci., 68 (12): 1510-1514.
    • (1979) J. Pharm. Sci , vol.68 , Issue.12 , pp. 1510-1514
    • Boakye Yiadom, K.1    Herman-Ackah, S.M.2
  • 7
    • 0032515931 scopus 로고    scopus 로고
    • The DNA intercalating alkaloid Cryptolepine interacts with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells
    • Bonjean, K., M.C. Depauw.-Gillet ahd M.P. Defresne, 1998. The DNA intercalating alkaloid Cryptolepine interacts with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells. Biochemistry, 37 (5): 5136-5146.
    • (1998) Biochemistry , vol.37 , Issue.5 , pp. 5136-5146
    • Bonjean, K.M.C.1    Depauw2    Gillet ahd, M.P.3    Defresne4
  • 8
    • 0002894419 scopus 로고
    • Clinical Uses of Cryptolepis singuinolenta (Asclepiadaceae)
    • Boakye Yiadom, K. and S.O.A. Bamgbose Eds, Abstract No. 4, University of Science and Technology, Kumasi, Ghana
    • Boye, G.L. and O. Ampofo, 1983. Clinical Uses of Cryptolepis singuinolenta (Asclepiadaceae). In: Proceeding of the 1st International Symposium on Cryptolepine, Boakye Yiadom, K. and S.O.A. Bamgbose (Eds.). Abstract No. 4, University of Science and Technology, Kumasi, Ghana.
    • (1983) Proceeding of the 1st International Symposium on Cryptolepine
    • Boye, G.L.1    Ampofo, O.2
  • 9
    • 0026327838 scopus 로고
    • Biological activities of cryptolepine, an alkaloid from Cryptolepis sanguinolenta
    • Cimanga, K., L. Pieters, M. Claeys, D. Vander Berghe and A.J. Vlietinck, 1991. Biological activities of cryptolepine, an alkaloid from Cryptolepis sanguinolenta. Planta Med., 57 (2): A98-A99.
    • (1991) Planta Med , vol.57 , Issue.2
    • Cimanga, K.1    Pieters, L.2    Claeys, M.3    Vander Berghe, D.4    Vlietinck, A.J.5
  • 10
    • 0034558060 scopus 로고    scopus 로고
    • Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: Relation to drug-induced apoptosis
    • Dassonneville, L., A. Lansiaux, A. Wattelet, N. Wattez, C. Mahieu, S. Van Miert, L. Pieters and C. Bailly, 2000. Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: Relation to drug-induced apoptosis. Eur. J. Pharmacol., 409 (1): 9-18.
    • (2000) Eur. J. Pharmacol , vol.409 , Issue.1 , pp. 9-18
    • Dassonneville, L.1    Lansiaux, A.2    Wattelet, A.3    Wattez, N.4    Mahieu, C.5    Van Miert, S.6    Pieters, L.7    Bailly, C.8
  • 11
    • 0030986823 scopus 로고    scopus 로고
    • Adverse effects of herbal remedies
    • De Smet P.G.A.M., 1997. Adverse effects of herbal remedies. Adverse Dnig Reaction Bull., 183 (1): 695-698.
    • (1997) Adverse Dnig Reaction Bull , vol.183 , Issue.1 , pp. 695-698
    • De Smet, P.G.A.M.1
  • 13
    • 0029129352 scopus 로고
    • In vitro an in vivo antimalarial activity of cryptolepine, a plant-derived indoloquinolone
    • Kirby, G.C., A. Paine, D.C. Warhurst, B.K. Noamesi and J.D. Phillipson, 1995. In vitro an in vivo antimalarial activity of cryptolepine, a plant-derived indoloquinolone. Phytother. Res., 9 (5): 359-363.
    • (1995) Phytother. Res , vol.9 , Issue.5 , pp. 359-363
    • Kirby, G.C.1    Paine, A.2    Warhurst, D.C.3    Noamesi, B.K.4    Phillipson, J.D.5
  • 14
    • 0036142318 scopus 로고    scopus 로고
    • The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites
    • Lisgarten, J.N., M. Coll, J. Portugal, C.W. Wright and J. Aymami, 2002. The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. Nat. Struct. Biol., 9 (1): 57-60.
    • (2002) Nat. Struct. Biol , vol.9 , Issue.1 , pp. 57-60
    • Lisgarten, J.N.1    Coll, M.2    Portugal, J.3    Wright, C.W.4    Aymami, J.5
  • 17
    • 0032248672 scopus 로고    scopus 로고
    • Herbal medicines in the emergency-a primer for toxicities and treatment
    • Moss, T.M., 1998. Herbal medicines in the emergency-a primer for toxicities and treatment J. Emerg. Nurs., 24 (6): 509-513.
    • (1998) J. Emerg. Nurs , vol.24 , Issue.6 , pp. 509-513
    • Moss, T.M.1
  • 19
    • 23944451082 scopus 로고    scopus 로고
    • Artemisinin-based combination therapies (ACIs): Best hope for malaria treatment but inaccessible to the needy
    • Mutabingwa, T.K., 2005. Artemisinin-based combination therapies (ACIs): Best hope for malaria treatment but inaccessible to the needy. Acta Trop., 95 (3): 305-315.
    • (2005) Acta Trop , vol.95 , Issue.3 , pp. 305-315
    • Mutabingwa, T.K.1
  • 20
    • 0019151223 scopus 로고
    • The α-adrenoceptor blocking properties of cryptolpeine on the rat isolated vas. deferens
    • Noamesi, B.K. and S.O.A. Bamgbose, 1980. The α-adrenoceptor blocking properties of cryptolpeine on the rat isolated vas. deferens. Planta Med., 39 (1): 51-56.
    • (1980) Planta Med , vol.39 , Issue.1 , pp. 51-56
    • Noamesi, B.K.1    Bamgbose, S.O.A.2
  • 22
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura, T. and R. Sato, 1964. The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem., 239 (7): 2370-2378.
    • (1964) J. Biol. Chem , vol.239 , Issue.7 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 23
    • 0024802399 scopus 로고
    • Effects of cryptolepine alone and in combination with dipyridamole on a mouse model of arterial thrombosis
    • Oyekan, A.O. ano J.P.O. Okafor, 1989. Effects of cryptolepine alone and in combination with dipyridamole on a mouse model of arterial thrombosis. J. Ethnopharmacol., 27 (1-2): 141-148.
    • (1989) J. Ethnopharmacol , vol.27 , Issue.1-2 , pp. 141-148
    • Oyekan, A.O.1    ano, J.P.O.2    Okafor3
  • 24
    • 0028202434 scopus 로고
    • Role of endothelium and cyclic GMP on renal vasodilator responses to cryptolepine in rats
    • Oyekan, A.O., 1994. Role of endothelium and cyclic GMP on renal vasodilator responses to cryptolepine in rats. J. Cardiovas. Pharmacol., 23 (4): 602-611.
    • (1994) J. Cardiovas. Pharmacol , vol.23 , Issue.4 , pp. 602-611
    • Oyekan, A.O.1
  • 25
    • 0028100032 scopus 로고
    • In vitro anti-bacterial screening of Cryptolepis sanguinolenta alkaloids
    • Paulo, A., A. Duarte and E.T. Gomes, 1994. In vitro anti-bacterial screening of Cryptolepis sanguinolenta alkaloids. J. Ethnopharmacol., 44 (2): 127-130.
    • (1994) J. Ethnopharmacol , vol.44 , Issue.2 , pp. 127-130
    • Paulo, A.1    Duarte, A.2    Gomes, E.T.3
  • 26
    • 0029417154 scopus 로고
    • Possible association of liver damage with the use of Chinese herbal medicine for skin disease
    • Perharic, L., D. Shaw, C. Leon, P.A. De-Smet and V. S. Murray, 1995. Possible association of liver damage with the use of Chinese herbal medicine for skin disease. Vet. Hum. Toxicol., 37 (6): 562-566.
    • (1995) Vet. Hum. Toxicol , vol.37 , Issue.6 , pp. 562-566
    • Perharic, L.1    Shaw, D.2    Leon, C.3    De-Smet, P.A.4    Murray, V.S.5
  • 27
    • 0027087040 scopus 로고
    • Antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors
    • Rauwald, H.W., M. Kober, E. Mutschler and G. Lambrecht, 1992. Antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors. Planta Med., 58 (6): 486-488.
    • (1992) Planta Med , vol.58 , Issue.6 , pp. 486-488
    • Rauwald, H.W.1    Kober, M.2    Mutschler, E.3    Lambrecht, G.4
  • 28
    • 0028788380 scopus 로고
    • The effect of cryptolepine on the morphology and survival of Escherichia coli and Candida albicans and Saccharomyces cerevisiae
    • Sawer I.K., M.I. Berry, M.W. Brown and J.L. Ford, 1995. The effect of cryptolepine on the morphology and survival of Escherichia coli and Candida albicans and Saccharomyces cerevisiae. J. Applied Bacteriol., 79 (3): 314-321.
    • (1995) J. Applied Bacteriol , vol.79 , Issue.3 , pp. 314-321
    • Sawer, I.K.1    Berry, M.I.2    Brown, M.W.3    Ford, J.L.4
  • 29
    • 4043068501 scopus 로고    scopus 로고
    • Shaping the Future
    • WHO, The World Health Report 2003, Technical Report Series, Geneva, Switzerland
    • WHO, 2003. Shaping the Future: The World Health Report 2003. Report of WHO Scientific Group. Technical Report Series 711, Geneva, Switzerland.
    • (2003) Report of WHO Scientific Group , vol.711


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