Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma

Familial Cancer

Volumn 7, Issue 2, 2008, Pages 141-149

  Prazeres, Hugo João ^a,b   Rodrigues, Fernando ^a   Soares, Paula ^b,c   Naidenov, Plamen ^a   Figueiredo, Paulo ^a   Campos, Beatriz ^a   Lacerda, Manuela ^a   Martins, Teresa C ^a,d  

^a Instituto Portugues de Oncologia Francisco Gentil Centro Regional de Oncologia de Coimbra SA   (Portugal)

^b University of Porto   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Familial non medullary thyroid cancer; Loci 19p13.2 and 2q21; Loss of heterozygosity; Tumour suppressor genes

Indexed keywords

ADULT; ARTICLE; BLOOD SAMPLING; CHROMOSOME 19P; CHROMOSOME 2Q; CLINICAL ARTICLE; DNA SEQUENCE; FAMILIAL CANCER; FAMILY STUDY; FEMALE; GENE CLUSTER; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY LOSS; HUMAN; MALE; MICROSATELLITE MARKER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; THYROID CARCINOMA; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; ALLELES; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENES, TUMOR SUPPRESSOR; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIGENE FAMILY; RISK FACTORS; THYROID NEOPLASMS;

EID: 45749141296     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-007-9160-x     Document Type: Article

References (25)

1. Schlumberger MJ (1998) Papillary and follicular thyroid carcinoma. N Engl J Med 338:297-306
2. Stoffer SS, Van Dyke DL, Bach JV et al (1986) Familial papillary carcinoma of the thyroid. Am J Med Genet 25:775-782
3. Malchoff CD, Malchoff DM (2006) Familial nonmedullary thyroid carcinoma. Cancer Control 13:106-110
4. Grossman RF, Tu SH, Duh QY, et al (1995) Familial nonmedullary thyroid cancer: an emerging entity that warrants aggressive treatment. Arch Surg 130:892-897
5. Houlston RS, Stratton MR (1995) Genetics of non-medullary thyroid cancer. Q J Med 88:685-693
6. Malchoff CD, Malchoff DM (1999) Familial nonmedullary thyroid carcinoma. Semin Surg Oncol 16:16-18
7. Burgess JR, Duffield A, Wilkinson SJ et al (1997) Two families with an autossomal dominant inheritance pattern for papillary carcinoma of the thyroid. J Clin Endocrinol Metabol 82:345-348
8. Hemminki K, Dong C (2000) Familial relationships in thyroid cancer by histopathological subtype. Int J Cancer 85:201-205
9. Pal T, Vogl FD, Chappuis PO et al (2001) Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study. J Clin Endocrinol Metabol 86:5307-5312
10. Frich L, Glattre E, Akslen LA (2001) Familial occurrence of nonmedullary thyroid cancer: a population-based study of 5673 first-degree relatives of thyroid cancer patients from Norway. Cancer Epidemiol Biomarkers Prev 10:113-117
11. Hemminki K, Eng C, Chen B (2005) Familial risks for non-medullary thyroid cancer. J Clin Endocrinol Metabol 90:5747-5753
12. Alsanea O, Wada N, Ain K et al (2000) Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series. Surgery 128:1043-1050
13. Uchino S, Noguchi S, Kawamoto H et al (2002) Familial nonmedullary thyroid carcinoma characterized by multifocality and a high recurrence rate in a large study population. World J Surg 26:897-902
14. Bignell GR, Canzian F, Shayeghi M et al (1997) Familial nontoxic multinodular goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. Am J Hum Genet 61:1123-1130
15. Canzian F, Amati P, Harach HR, et al (1998) A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromomosome 19p132. Am J Hum Genet 63:1743-1748
16. Malchoff CD, Sarfarazi M, Tendler B et al (2000) Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metabol 85:1758-1764
17. McKay JD, Lesueur F, Jonard L et al (2001) Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21. Am J Hum Genet 69:440-446
18. Bevan S, Pal T, Greenberg CR et al (2001) A comprehensive analysis of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer: confirmation of linkage to TCO1. J Clin Endocrinol Metabol 86:3701-3704
19. McKay JD, Thompson D, Lesueur F et al (2004) Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. J Med Genet 41:407-412
20. Bonora E, Evangelisti C, Bonichon F et al (2006) Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas. Br J Cancer 11:1529-1536
21. Musholt TJ, Musholt PB, Petrich T et al (2000) Familial papillary thyroid carcinoma: genetics, criteria for diagnosis, clinical features, and surgical treatment. World J Surg 24:1409-1417
22. Vasen HF, Mecklin JP, Khan PM, Lynch HT (1991) The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34:424-425
23. Caldas C, Carneiro F, Lynch HT et al (1999) Familial gastric cancer: overview and guidelines for management. J Med Genet 36:873-880
24. Stankov K, Pastore A, Toschi L et al (2004) Allelic loss at chromosomes 2q21 and 19p13.2 in oxyphilic thyroid tumours. Int J Cancer 111:463-467
25. Charkes ND (2006) On the prevalence of familial nonmedullary thyroid cancer in multiply affected kindreds. Thyroid 16:181-186