Evidence that chronic hypoxia causes reversible impairment on male fertility

Asian Journal of Andrology

Volumn 10, Issue 4, 2008, Pages 602-606

  Verratti, Vittore ^a   Berardinelli, Francesc ^a   Di Giulio, Camillo ^a   Bosco, Gerardo ^a   Cacchio, Marisa ^a   Pellicciotta, Mario ^b   Nicolai, Michele ^a   Martinotti, Stefano ^a   Tenaglia, Raffaele ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

High altitude; Hypoxia; Male fertility; Seminological parameters

Indexed keywords

OXYGEN;

ADULT; AGED; ALTITUDE; ARTICLE; CONTROLLED STUDY; EJACULATION; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MALE FERTILITY; MOUNTAINEERING; NORMAL HUMAN; OLIGOSPERMIA; OXYGEN SUPPLY; SEA LEVEL; SEMEN ABNORMALITY; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; VOLUNTEER;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; ALTITUDE; ANOXIA; HUMANS; INFERTILITY, MALE; MALE; MIDDLE AGED; MOUNTAINEERING; OLIGOSPERMIA; SPERM COUNT; SPERM MOTILITY; SPERMATOGENESIS;

EID: 45749134679     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2008.00346.x     Document Type: Article

References (22)

1. Clegg EJ. Fertility and early growth. In: Baker PT. editor The Biology of High Altitude Peoples. Cambridge: Cambridge University Press; 1978: 65-115.
2. Monge C. Acclimatization in the Andes. Baltimore: Johns Hopkins Press; 1948, 113.
3. Beall CM, Blangero J, Williams-Blangero S, Goldstein MC. Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders. Am J Phys Anthropol 1994; 95: 271-6.
4. Beall CM, Almasy LA, Blangero J, Williams-Blangero S, Brittenham GM, Strohl KP, et al. Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m. Am J Phys Anthropol 1999; 108: 41-51.
5. Okumura A, Fuse H, Kawauchi Y, Mizuno I, Akashi T. Changes in male reproductive function after high altitude mountaineering. High Alt Med Biol 2003; 4: 349-53.
6. Eckes L. Altitude adaptation. I V. Fertility and reproduction at high altitudes. Gegenbaurs Morphol Jahrb 1976; 122: 761-70.
7. Gasco M, Rubio J, Chung A, Villegas L, Gonzales GF. Effect of high altitude exposure on spermatogenesis and epididymal sperm count in male rats. Andrologia 2003; 35: 368-74.
8. Saxena DK. Effect of hypoxia by intermittent altitude exposure on semen characteristics and testicular morphology of male rhesus monkeys. Int J Biometeorol 1995; 38: 137-40.
9. Okumura A, Fuse H, Kawauchi Y, Mizuno I, Akashi T. Changes in male reproductive function after high altitude mountaineering. High Alt Med Biol 2003; 4: 349-53.
10. Bustos-Obregon E, Olivares A. Efecto de la hipoxia en la reproducción de mamiferos. B. Función testicular postexposición a ambiente de altura. In: El hombre y los ecosistemas de montaòa (MAB-6). Montevideo: UNESCO-ROSTLAC; 1982: 65-80.
11. Farias JG, Bustos-Obregén E, Orellana R, Bucarey JL, Quiroz E, Reyes JG. Effects of chronic hypobaric hypoxia on testis histology and round spermatid oxidative metabolism. Andrologia 2005; 37: 47-52.
12. Gosney JR. Effects of hypobaric hypoxia on the Leydig cell population of the testis of the rat. J Endocrinol 1984; 103: 59-62.
13. Shevantaeva ON, Kosyuga YI. Effect of acute hypobaric hypoxia on spermatogenesis and lactate concentration in testicular tissue of male albino rats. Bull Exp Biol Med 2006; 141: 20-2.
14. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-cervical Mucus Interaction, 4th edn. Cambridge: Cambridge University Press; 1999.
15. Beall CM. Tibetan and Andean patterns of adaptation to high-altitude hypoxia. Hum Biol 2000; 72: 201-28.
16. Prabhakar NR, Kline DD. Ventilatory changes during intermittent hypoxia: importance of pattern and duration. High Alt Med Biol 2002; 3: 195-204.
17. Setchell BP. The Parkes Lecture. Heat and the testis. J Reprod Fertil 1998; 114: 179-94.
18. Zalata A, Hafez T, Comhaire F. Evaluation of the role of reactive oxygen species in male infertility. Hum Reprod 1995; 10: 1444-51.
19. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003; 79: 829-43.
20. Verratti V, Di Giulio C, Berardinelli F, Brunetti L, Orlando G, Vacca M, et al. Oxidative stress in testis of neonatal, young adult and aged rat. Andrology Update 2007; 1: 1-7.
21. Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J Androl 2003; 5: 231-42.
22. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001; 345: 1388-93.