Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 +CD45RA+ T-cells in old age

Biological Chemistry

Volumn 389, Issue 5, 2008, Pages 561-568

  Herndler Brandstetter, Dietmar ^a   Veel, Ellen ^a   Laschober, Gerhard T ^a   Pfister, Gerald ^a,c   Brunner, Stefan ^a   Walcher, Susanne ^a   Parson, Walther ^b   Lepperdinger, Günter ^a   Grubeck Loebenstein, Beatrix ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Aging; CD8 T cell; Gene expression; Immune system; Naive

Indexed keywords

CD45RA ANTIGEN; CD45RO ANTIGEN; INTERLEUKIN 2; MARKER VACCINE; T LYMPHOCYTE RECEPTOR;

AGED; AGING; ARTICLE; CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; GENE EXPRESSION; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; INFLUENZA VACCINATION; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; TELOMERE; VACCINATION;

ADULT; AGED; AGING; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; DNA, COMPLEMENTARY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENES, T-CELL RECEPTOR; HUMANS; IN SITU HYBRIDIZATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STIMULATION, CHEMICAL; TELOMERE;

EID: 45749134615     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.052     Document Type: Article

References (42)

1. Akbar, A.N. and Fletcher, J.M. (2005). Memory T-cell homeostasis and senescence during aging. Curr. Opin. Immunol. 17, 480-485.
2. + T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly individuals. J. Virol. 79, 3675-3683.
3. Barker, W.H. and Mullooly, J.P. (1982). Pneumonia and influenza deaths during epidemics: implications for prevention. Arch. Intern. Med. 142, 85-89.
4. Betz, U.A. and Muller, W. (1998). Regulated expression of gp130 and IL-6 receptor a chain in T-cell maturation and activation. Int. Immunol. 10, 1175-1184.
5. Cho, B.K., Rao, V.P., Ge, Q., Eisen, H.N., and Chen, J. (2000). Homeostasis-stimulated proliferation drives naive T-cells to differentiate directly into memory T-cells. J. Exp. Med. 192, 549-556.
6. + T-cells provides new insights on immunodeficiency in aging. Blood 95, 2860-2868.
7. + T-cells and its implication in T-cell aging. Immunol. Rev. 205, 190-206.
8. + T-cell response. Blood 108, 3363-3370.
9. + T-cell response. Blood 108, 3363-3370.
10. Fehrer, C., Voglauer, R., Wieser, M., Pfister, G., Brunauer, R., Cioca, D., Grubeck-Loebenstein, B., and Lepperdinger, G. (2006). Techniques in gerontology: cell lines as standards for telomere length and telomerase activity assessment. Exp. Gerontol. 41, 648-651.
11. + T-cells in healthy carriers are continuously driven to replicative exhaustion. J. Immunol. 175, 8218-8225.
12. Gavazzi, G. and Krause, K.H. (2002). Ageing and infection. Lancet Infect. Dis. 2, 659-666.
13. Goldrath, A.W., Bogatzki, L.Y., and Bevan, M.J. (2000). Naive T-cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192, 557-564.
14. Grubeck-Loebenstein, B., Berger, P., Saurwein-Teissl, M., Zisterer, K., and Wick, G. (1998). No immunity for the elderly. Nat. Med. 4, 870.
15. Haynes, B.F., Markert, M.L., Sempowski, G.D., Patel, D.D., and Hale, L.P. (2000). The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18, 529-560.
16. Haynes, L., Eaton, S.M., Burns, E.M., Randall, T.D., and Swain, S.L. (2003). CD4 T-cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc. Natl. Acad. Sci. USA 100, 15053-15058.
17. + T-cells are potent memory cells in old age. J. Immunol. 175, 1566-1574.
18. Holmes, S., He, M., Xu, T., and Lee, P.P. (2005). Memory T-cells have gene expression patterns intermediate between naive and effector. Proc. Natl. Acad. Sci. USA 102, 5519-5523.
19. Kaech, S.M., Hemby, S., Kersh, E., and Ahmed, R. (2002). Molecular and functional profiling of memory CD8 T-cell differentiation. Cell 111, 837-851.
20. Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J.A., Sinclair, A.J., Nayak, L., and Moss, P.A. (2002). Cytomegalovirus seropositivity drives the CD8 T-cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169, 1984-1992.
21. + T-cells constrains the TCR repertoire in healthy human adults. Eur. J. Immunol. 35, 1987-1994.
22. -ΔΔCT method. Methods 25, 402-408.
23. + T-cells. Immunity 22, 259-270.
24. Mi, H., Lazareva-Ulitsky, B., Loo, R., Kejariwal, A., Vandergriff, J., Rabkin, S., Guo, N., Muruganujan, A., Doremieux, O., Campbell, M.J., et al. (2005). The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res. 33, D284-288.
25. Murali-Krishna, K. and Ahmed, R. (2000). Cutting edge: naive Tcells masquerading as memory cells. J. Immunol. 165, 1733-1737.
26. Nadon, N.L., Mohr, D., and Becker, K.G. (2005). National Institute on aging microarray facility - resources for gerontology research. J. Gerontol. A Biol. Sci. Med. Sci. 60, 413-415.
27. Naylor, K., Li, G., Vallejo, A.N., Lee, W.W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C.M., and Goronzy, J.J. (2005). The influence of age on T-cell generation and TCR diversity. J. Immunol. 174, 7446-7452.
28. Nikolich-Zugich, J., Slifka, M.K., and Messaoudi, I. (2004). The many important facets of T-cell repertoire diversity. Nat. Rev. Immunol. 4, 123-132.
29. Pawelec, G., Akbar, A., Caruso, C., Effros, R., Grubeck-Loebenstein, B., and Wikby, A. (2004). Is immunosenescence infectious? Trends Immunol. 25, 406-410.
30. Pfister, G., Weiskopf, D., Lazuardi, L., Kovaiou, R.D., Cioca, D.P., Keller, M., Lorbeg, B., Parson, W., and Grubeck-Loebenstein, B. (2006). Naive T-cells in the elderly: are they still there? Ann. N.Y. Acad. Sci. 1067, 152-157.
31. Raffeiner, B., Dejaco, C., Duftner, C., Kullich, W., Goldberger, C., Vega, S.C., Keller, M., Grubeck-Loebenstein, B., and Schirmer, M. (2005). Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. Arthritis Res. Ther. 7, R1412-1420.
32. Rozen, S. and Skaletsky, H. (2000). Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132, 365-386.
33. Saeed, A.I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003). TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34, 374-378.
34. - T-cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168, 5893-5899.
35. ++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. J. Immunol. 170, 613-619.
36. + T-cells to antigen stimulation in vivo. Nat. Immunol. 1, 47-53.
37. + T-cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length. Immunology 119, 243-253.
38. + T-cellsubsets in the elderly. Hum. Immunol. 68, 86-90.
39. Weyand, C.M., Fulbright, J.W., and Goronzy, J.J. (2003). Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp. Gerontol. 38, 833-841.
40. Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Lofgren, S., Nilsson, B.O., Ernerudh, J., Pawelec, G., and Johansson, B. (2005). An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J. Gerontol. A Biol. Sci. Med. Sci. 60, 556-565.
41. Willinger, T., Freeman, T., Hasegawa, H., McMichael, A.J., and Callan, M.F. (2005). Molecular signatures distinguish human central memory from effector memory CD8 T-cellsubsets. J. Immunol. 175, 5895-5903.
42. Wolters, B., Junge, U., Dziuba, S., and Roggendorf, M. (2003). Immunogenicity of combined hepatitis A and B vaccine in elderly individuals. Vaccine 21, 3623-3628.