A new player in gene therapy for pain?

Gene Therapy

Volumn 15, Issue 13, 2008, Pages 953-954

  Pohl, M ^a   Fink, D J ^b  

^a INSERM   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANALGESIC AGENT; BETA ENDORPHIN; DNA; ENKEPHALIN; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; MORPHINE; PARVOVIRUS VECTOR;

ALLODYNIA; ANALGESIA; BRAIN INFECTION; CEREBROSPINAL FLUID; CLINICAL TRIAL; DISEASE MODEL; DNA SEQUENCE; DRUG POTENCY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; NEUROPATHIC PAIN; NEUROTRANSMISSION; NONHUMAN; NOTE; PAIN; PRIORITY JOURNAL; SEROTYPE; SPINAL GANGLION; SYNAPSE; TRANSGENE; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; BETA-ENDORPHIN; GENE THERAPY; GENETIC VECTORS; HUMANS; INJECTIONS, SPINAL; PAIN; PROTEIN PRECURSORS; RATS; TRANSDUCTION, GENETIC;

EID: 45749127439     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.80     Document Type: Note

References (9)

1. Storek B, Reinhardt M, Wang C, Janssen WG, Harder NM, Banck MS et al. Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain. Proc Natl Acad Sci USA 2008; 105: 1055-1060.
2. Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007; 132: 237-251.
3. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001; 413: 203-210.
4. Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat Rev Neurosci 2005; 6: 521-532.
5. Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain 2006; 126: 294-308.
6. Antunes Bras JM, Epstein AL, Bourgoin S, Hamon M, Cesselin F, Pohl M. Herpes simplex virus 1-mediated transfer of preproenkephalin A in rat dorsal root ganglia. J Neurochem 1998; 70: 1299-1303.
7. Hao S, Mata M, Glorioso JC, Fink DJ. HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neumpathic pain. Mol Pain 2006; 2: 6.
8. Mata M, Hao S, Fink DJ. Applications of gene therapy to the treatment of chronic pain. Curr Gene Ther 2008; 8: 42-48.
9. Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: Vector toolkit for human gene therapy. Mol Ther 2006; 14: 316-327.