Integration of global signaling pathways, cAMP-PKA, MAPK and TOR in the regulation of FLO11

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Vinod, P K ^a   Sengupta, Neelanjan ^a   Bhat, P J ^a   Venkatesh, K V ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM SULFATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLOCCULIN 11; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN; SACCHAROMYCES CEREVISIAE PROTEIN; TARGET OF RAPAMYCIN KINASE; TREHALOSE; MEMBRANE PROTEIN; MUC1 PROTEIN, S CEREVISIAE; PROTEIN SERINE THREONINE KINASE; TARGET OF RAPAMYCIN PROTEIN, S CEREVISIAE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPERIMENTAL STUDY; FUNGUS CULTURE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SWITCHING; NEGATIVE FEEDBACK; NITROGEN AVAILABILITY; NONHUMAN; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; STARVATION; STEADY STATE; TRANSCRIPTION INITIATION; VEGETATIVE GROWTH; ADAPTATION; FEEDBACK SYSTEM; GENETICS; METABOLISM;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

ADAPTATION, PHYSIOLOGICAL; AMMONIUM SULFATE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, FUNGAL; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; NITROGEN; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 45749108672     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001663     Document Type: Article

References (59)

1. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR (1992) Unipolar Cell Divisions in the Yeast Saccharomyces-Cerevisiae Lead to Filamentous Growth-Regulation by Starvation and Ras. Cell 68: 1077-1090.
2. Kron SJ, Styles CA, Fink GR (1994) Symmetrical Cell-Division in Pseudohyphae of the Yeast Saccharomyces-Cerevisiae. Mol Biol Cell 5: 1003-1022.
3. Rua D, Tobe BT, Kron SJ (2001) Cell cycle control of yeast filamentous growth. Curr Opin Microbiol 4: 720-727.
4. Roberts RL, Fink GR (1994) Elements of a Single Map Kinase Cascade in Saccharomyces-Cerevisiae Mediate 2 Developmental Programs in the Same Cell-Type - Mating and Invasive Growth. Genes & Dee 8: 2974-2985.
5. Liu HP, Styles CA, Fink GR (1993) Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids. Science 262: 1741-1744.
6. Lorenz MC, Heitman J (1997) Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J 16: 7008-7018.
7. Pan XW, Heitman J (1999) Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol 19: 4874-4887.
8. Rupp S, Summers E, Lo HJ, Madhani H, Fink G (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBOJ 18: 1257-1269.
9. Cutler NS, Pan XW, Heitman J, Cardenas ME (2001) The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol Biol Cell 12: 4103-4113.
10. Rohde JR, Cardenas ME (2003) Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi. Tor-Target of Rapamycin. pp 53-72.
11. Lo WS, Dranginis AM (1996) FLO11, a yeast gene related to the STA genes, encodes a novel cell surface flocculin. J Bacteriol 178: 7144-7151.
12. Lo WS, Dranginis AM (1998) The cell surface floccuim Flo11 is required for pseudohyphae formation and invasion by Saccharomyces, cerevisiae, Mol Biol Cell 9: 161-171.
13. Lorenz MC, Heitman J (1998) The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J 17: 1236-1247.
14. Rohde J, Heitman J, Cardenas ME (2001) The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276: 9583-9586.
15. Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J (1999) The TOR signaling cascade regulates gene expression in response to nutrients. Genes & Dev 13: 3271-3279.
16. Sengupta N, Vinod PK, Venkatesh KV (2007) Crosstalk between cAMP-PKA and MAP kinase pathways is a key regulatory design necessary to regulate FLO11 expression. Biophys Chem 125: 59-71.
17. Gagiano M, Bauer FF, Pretorius IS (2002) The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae. FEMS Yeast Res 2: 433-470.
18. Gancedo JM (2001) Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev 25: 107-123.
19. Mosch HU, Roberts RL, Fink GR (1996) Ras2 signals via the Cdc42/Ste20/ mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc, Natl Acad Sci U S A 93: 5352-5356.
20. Biswas K, Morschhauser J (2005) The Mep2p ammonium permease controls nitrogen aarvation-induced filamentous growth in Candida albicans. Mol Microbiol 56: 649-669.
21. Van Nuland A, Vandormael P, Donaton M, Alenquer M, Lourenco A, et al. (2006) Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Mol Microbiol 59: 1485-1505.
22. Peeters T, Louwet W, Gelade R, Nauwelaers D, Thevelein JM, et al. (2006) Kelch-repeat proteins interacting with the G(alpha) protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103: 13034-13039.
23. Harashima T, Heitman J (2002) The G alpha protein GPa2 controls yeast differentiation by interacting with Kelch repeat proteins that mimic G beta subunits. Mol Cell 10: 163-173.
24. Harashima T, Heitman J (2005) G alpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. Mol Biol Cell 16: 4557-4571.
25. Batlle M, Lu AL, Green DA, Xue Y, Hirsch JP (2003) Krh1 p and Krh2p act downstream of the Gpa2p G alpha subunit to negatively regulate haploid invasive growth. J Cell Sci 116: 701-710.
26. Harashima T, Anderson S, Yates JR, Heitman J (2006) The Kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22: 819-830.
27. Cullen PJ, Sabbagh W, Graham E, Irick MM, van Olden EK, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes & Dev 18: 1695-1708.
28. Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103: 253-262.
29. Cooper TG (2002) Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. FEMS Microbiol Rev 26: 223-238.
30. Crespo JL, Hall MN (2002) Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev 66: 579-591.
31. Hardwick JS, Kuruvilla FG, Tong JK, Sharnji AF, Schreiber SL (1999) Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci U S A 96: 14866-14870.
32. DiComo CJ, Arndt KT (1996) Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes & Dev 10: 1904-1916.
33. J iang Y, Broach JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBOJ 18: 2782-2792.
34. Santhanam A, Hartley A, Duvel K, Broach JR, Garrett S (2004) PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryotic Cell 3: 1261-1271.
35. Parrou JL, Enjalbert B, Plourde L, Bauche A, Gonzalez B, et al. (1999) Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiae. Yeast 15: 191-203.
36. Francois J, Parrou JL (2001) Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 25: 125-145.
37. Barbet NC, Schneider U, Helliwell SB, Stansfield I, Tuite MF, et al. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7: 25-42.
38. Berset C, Trachsel H, Altmann M (1998) The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 95: 4264-4269.1.
39. Cherkasova VA, Hinnebusch AG (2003) Translational control by TOR and TAP42 through dephosphorylation of eIF2 alpha kinase GCN2. Genes & Dev 17: 859-872.
40. Gallego C, Gari E, Colomina N, Herrero E, Aldea M (1997) The Cln3 cyclin is down-regulated by translational repression and degradation during the G(1) arrest caused by nitrogen deprivation in budding yeast. EMBOJ 16: 7196-7206.
41. Loeb JDJ, Karentseva TA, Pan T, Sepulveda-Becerra M, Liu HP (1999) Saccharomyces cerevisiae G1 cyclins are differentially involved in invasive and pseudohyphal growth independent of the filamentation mitogen-activated protein kinase pathway. Genetics 153: 1535-1546.
42. Ahn SH, Acurio A, Kron SJ (1999) Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth. Mol Biol Cell 10: 3301-3316.
43. Oehlen L, Cross FR (1998) Potential regulation of Ste20 function by the Cln1-Cdc28 and Cln2-Cdc28 cyclin-dependent protein kinases. J Biol Chem 273: 25089-25097.
44. Pan XW, Heitman J (2000) Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol 20: 8364-8372.
45. Gorner W, Durchschlag E, Wolf J, Brown EL, Ammerer G, et al. (2002) Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor. EMBO J 21: 135-144.
46. Hounsa CG, Brandt EV, Thevelein J, Hohmann S, Prior BA (1998) Role of trehalose in survival of Saccharomyces cerevisiae under osmotic stress. Microbiol 144: 671-680.
47. O'Rourke SM, Herskowitz I (2004) Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis. Mol Biol Cell 15: 532-542.
48. Ferrell JE, Xiong W (2001) Bistability in cell signaling: How to make continuous processes discontinuous and reversible processes irreversible. Chaos 11: 227-236.
49. Ferrell JE (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14: 140-148.
50. Stanhill A, Schick N, Fogelberg D (1999) The yeast Ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response. Mol Cell Biol 19: 7529-7538.
51. Gietz RD, Woods RA (2002) Transformation of yeast by lithium acetate/ single-stranded carrier DNA/polyethylene glycol method. Guide to Yeast Genetics and Molecular and Cell Biology, Pt B. pp 87-96.
52. Hojeong KEH, Seok SP (2003) A Sensitive Method for the Measurement of Ammonium in Soil Extract and Water. Commun Soil Sci Plant Anal 34: 2193-2201.
53. Adams AGD, Kaiser CA, Stearns T (1997) Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
54. Liu Chuanbin XJ, Bai F, Su Z (1998) Trehalose extraction from Saccharomyces cerevisiae after microwave treatment. Biotechnol Tech 12: 941-943.
55. Lorenz MC, Pan XW, Harashima T, Cardenas ME, Xue Y, et al. (2000) The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 154: 609-622.
56. Zurita-Martinez SA, Cardenas ME (2005) Tor and cyclic AMP-protein kinase A: Two parallel pathways regulating expression of genes required for cell growth. Eukaryotic Cell 4: 63-71.
57. Hubler L, Bradshawrouse J, Heideman W (1993) Connections between the Ras-Cyclic Amp Pathway and G(I)-Cyclin Expression in the Budding Yeast Saccharomyces-Cerevisiae. Mol Cell Biol 13: 6274-6282.
58. Markwardt DD, Garrett JM, Eberhardy S, Heideman W (1995) Activation of the Ras/Cyclic Amp Pathway in the Yeast Saccharomyces-Cerevisiae Does Not Prevent G(1) Arrest in Response to Nitrogen Starvation. J Bacteriol 177: 6761-6765.
59. Koshland Jr DE, Goldbeter A, Stock JB (1982) Amplification and adaptation in regulatory and sensory systems. Science 217: 220-225.