The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss

Clinical and Applied Thrombosis/Hemostasis

Volumn 14, Issue 3, 2008, Pages 356-359

  Yildiz, Zuleyha ^a   Ulu, Arzu ^a   Incesulu, Armagan ^b   Ozkaptan, Yalcin ^c   Akar, Nejat ^a,d  

^a ANKARA UNIVERSITY   (Turkey)

^b Social Security Hospital   (Turkey)

^c GULHANE SCHOOL OF MEDICINE   (Turkey)

^d NONE   (Turkey)

Author keywords

EPCR; Idiopathic sudden hearing loss; Thrombotic risk factors; Vascular impairment

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; PROTHROMBIN;

ADOLESCENT; ADULT; ARTICLE; COCHLEA BLOOD FLOW; CONTROLLED STUDY; DNA POLYMORPHISM; ENDOTHELIUM CELL; FEMALE; GENE FREQUENCY; GENE INSERTION; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PERCEPTION DEAFNESS; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; STATISTICAL SIGNIFICANCE; SUDDEN DEAFNESS; THROMBOSIS;

ADOLESCENT; ADULT; ANTIGENS, CD; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FACTOR V; FEMALE; HEARING LOSS, SUDDEN; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTAGENESIS, INSERTIONAL; PLASMINOGEN ACTIVATOR INHIBITOR 1; POINT MUTATION; PROTHROMBIN; RECEPTORS, CELL SURFACE; RISK FACTORS; THROMBOSIS;

EID: 45749088959     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029607306399     Document Type: Article

References (23)

1. Patscheke JH, Arndt J., Dietz K., Zenner HP, Reuner KH The prothrombin G20210A mutation is a risk factor for sudden hearing loss in young patients. Thromb Haemost. 2001 ; 86: 118-119.
2. Byl FM Jr. Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope. 1984 ; 94: 647-661.
3. Mattox DE, Leyles CA Idiopathic sudden sensorineural hearing loss. Am J Otol. 1989 ; 10: 242-247.
4. Mattox DE, Simmons FB Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1977 ; 86: 463-480.
5. Akar N., Akar E., Yilmaz E. Factor V (his1299arg) in Turkish patients with venous thromboembolism. Am J Hematol. 2000 ; 63: 102-103.
6. Akar N., Akar E., Dalgin G., Sozuoz A., Omurlu K., Cin S. Frequency of Factor V 1691 G-A mutation in Turkish population. Thromb Haemost. 1997 ; 78: 1527-1529.
7. Akar N., Akar E., Yilmaz E., Sozuoz E. Frequency of FV 1299 His-Arg (A4070G) in Turkish Cypriots. Turk J Haematol. 2001 ; 18: 243-244.
8. Akar N., Misirlioglu M., Akar E., Avcu F., Yalcin A., Sozuoz A. Prothrombin gene 20210G-A mutation in Turkish population. Am J Hemotol. 1998 ; 58: 249.
9. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM A common genetic variation in the 3′untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996 ; 88: 3698-3703.
10. Margaglione M., Bossone A., Coalizzo D., et al. FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile. Thromb Haemost. 2002 ; 87: 32-36.
11. Esmon CT The protein C pathway. Chest. 2003 ; 124 (3 Suppl). 26-32.
12. Akar N., Yilmaz E., Akar E., Avcu F., Yalcin A., Cin S. Effect of plasminogen activator inhibitor-1 4G/5G polymorphism in Turkish deep vein thrombotic patients with and without FV1691G-A. Thromb Res. 2000 ; 97: 227-230.
13. Den Heijer M., Koster T., Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med. 1996 ; 334: 759-762.
14. Frosst P., Blom HJ, Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase. Nat Genet. 1995 ; 10: 111-113.
15. Akar N., Akar E., Ozel D., Deda G., Sipahi T. Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 ; 102: 115-120.
16. Akar N., Akar E., Akcay R., Avcu F., Yalcin A., Cin S. Effect of methylenetetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res. 2000 ; 97: 163-167.
17. Gorur K., Tuncer U., Eskandari G., Ozcan C., Unal M., Ozsahinoglu C. The role of Factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss. Otol Neurotol. 2005 ; 26: 599-601.
18. Capaccio P., Ottaviani F., Cuccarini V., et al. Sudden hearing loss and MTHFT 677C>T/1298A>C gene polymorphisms. Genet Med. 2005 ; 7: 206-208.
19. Akar N., Gokdemir R., Ozel D., Akar E. Endothelial cell protein C receptor (EPCR) gene exon III, 23 bp insertion mutation in the Turkish pediatric thrombotic patients. Thromb Haemost. 2002 ; 88: 1068-1069.
20. Esmon CT Crosstalk between inflammation and thrombosis. Maturitas. 2004 ; 47: 305-314.
21. Saposnik B., Reny JL, Gaussem P., Emmerich J., Aiach M., Gandrille S. A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood. 2003 ; 103: 1311-1318.
22. Uitte de Willige S., Van Marion V., Rosendaal FR, Vos HL, de Visser MC, Bertina RM Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis. J Thomb Haemost. 2004 ; 2: 1305-1310.
23. Sipahi T., Pocan H., Akar N. Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. Clin Appl Thromb Hemost. 2005: 12: 47-54.