Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

Genetics in Medicine

Volumn 7, Issue 3, 2005, Pages 206-208

  Capaccio, P ^a   Ottaviani, F ^a   Cuccarini, V ^a   Ambrosetti, U ^c   Fagnani, E ^c   Bottero, A ^a   Cenzuales, S ^b   Cesana, B M ^c   Pignataro, Lorenzo ^c  

^a Clinica Otorinolaringoiatrica   (Italy)

^b Centro Trasfusionale   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

MTHFR gene polymorphisms; Sudden hearing loss; Vascular impairment

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CLINICAL ARTICLE; COCHLEA; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENETIC ANALYSIS; HUMAN; MALE; MTHFR GENE; PATHOGENESIS; RISK ASSESSMENT; RISK FACTOR; SUDDEN DEAFNESS; VASCULAR DISEASE;

CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEARING LOSS, SUDDEN; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 16444383575     PISSN: 10983600     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.GIM.0000157817.92509.45     Document Type: Article

References (19)

1. Ottaviani F, Cadoni G, Marinelli L, Fetoni AR, De Santis A, Romito A, Vulpiani P, Manna R. Anti-Endothelial Autoantibodies in Patients with Sudden Hearing Loss. Laryngoscope 1999;109(7, Part 1):1084-7.
2. Patscheke JH, Arndt I, Dietz K, Zenner HP, Reuner KH. The Prothrombin G20210A Mutation is a Risk Factor for Sudden Hearing Loss in Young Patients. Thromb Haemost 2001;86:1118-9.
3. Schweinfurth IM, Cacace AT. Cochlear Ischemia Induced by Circulating Iron Particles under Magnetic Control: an Animal Model for Sudden Hearing Loss. Am J Otol 2000;21:636-40.
4. Lane DA, Grant PJ. Role of Hemostatic Gene Polymorphisms in Venous and Arterial Thrombotic Disease. Blood 2000;95(5):1517-32.
5. Abbate R, Sardi I, Pepe G, Marcucci R, Brunelli T, Prisco D, Fatini C, Capanni M, Gensini GF. The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated with an increased risk for coronary artery disease (CAD). Thromb Haemost 1998 Apr;79(4):727-30.
6. Sacchi E, Tagliabue L, Duca F, Mannucci PM. High Frequency of the C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in Northern Italy. Thromb Haemost 1997 Aug;78(2):963-4.
7. De Marco P, Calevo MG, Moroni A, Arata L, Merello E, Finnell RH, Zhu H, Andreussi L, Cama A, Capra V. Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet 2002;47(6):319-24.
8. Couturaud F, Oger E, Abalain JH, Chenu E, Guias B, Floch HH, Mercier B, Mottier D, Leroyer C. Methylenetetrahydrofolate Reductase C677T Genotype and Venous Thromboembolic Disease. Respiration 2000;67:657-61.
9. Harrington DJ, Malefora A, Schmeleva V, Kapustin S, Papayan L, Blinov M, Harrington P, Mitchell M, Savidge GF. Genetic Variations Observed in Arterial and Venous Thromboembolism - Relevance for Therapy, Risk Prevention and Prognosis. Clin Chem Lab Med 2003;41(4):496-500.
10. Lievers KJA, Boers GHJ, Verhoef P, den Heijer M, Kluijtmans LAI, Van der Put NMJ, Trijbels FJM, Blom HJ. A Second Common Variant in the MTHFR Gene and its Relationship to MTHFR Enzyme Activity, Homocysteine, and Cardiovascular Disease Risk. J Mol Med 2001;79:522-8.
11. Ashfield-Watt PAL, Moat SJ, Doshi SN, Mc Dowell IFW. Folate, Homocysteine, Endothelial Function and Cardiovascular Disease. Biomed Pharmacother 2001;55:425-33.
12. Kim RJ, Becker RC. Association between factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J 2003 Dec; 146(6):948-57.
13. Kumar KS, Govindaiah V, Naushad SE, Devi RR, Jyothy A. Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss. J Obstet Gynaecol 2003 Jan;23(1):55-8.
14. Zetterberg H. Methylenetetrahydrofolate reductase and transcobalamin gene polymorphisms in human spontaneous abortion: biological and clinical implications. Reprod Biol Endocrinol 2004 Feb 17;2(1):7.
15. Rudack C, Langer C, Junker R. Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss. Hear Res 2004;191(1-2):41-8.
16. Mattson MP, Kruman II, Duan W. Folic acid and homocysteine in age-related disease. Ageing Res Rev 2002;1:95-111.
17. Genest J, Malinow MR. Homocysteine and coronary artery disease. Cun Opin Lipidol 1992;3:295-9.
18. Hirano K, Ikeda K, Kawase T, Oshima T, Kekehata S, Takahashi S, Sato T, Kobayashi T, Takasaka T. Prognosis of sudden deafness with special reference to risk factors of microvascular pathology. Ann's Nasus Larynx 1999;26:111-5.
19. Cadoni G, Agostino S, Scipione S, Galli I. Low serum folate levels: a risk factor for sudden sensorineural hearing loss? Acta Otolaryngol 2004;124(5):609-11.