Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel

Tissue Engineering - Part A.

Volumn 14, Issue 6, 2008, Pages 1089-1098

  Kikuchi, Takeshi ^a   Kubota, Satoshi ^a   Asaumi, Koji ^a   Kawaki, Harumi ^a   Nishida, Takashi ^a   Kawata, Kazumi ^a   Mitani, Shigeru ^a   Tabata, Yasuhiko ^b   Ozaki, Toshifumi ^a   Takigawa, Masaharu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BONE; CARTILAGE; COLLAGEN; COLLOIDS; HYDROGELS; MINERALOGY; MUSCULOSKELETAL SYSTEM; OSTEOBLASTS; PHOTOACOUSTIC EFFECT; PROTEINS;

(E ,3E) PROCESS; ARTICULAR CARTILAGE (AC); BONE DEFECTS; BONE REGENERATION; BONE-MARROW STROMAL CELL (BMSC); CONNECTIVE TISSUE GROWTH FACTOR (CTGF); ENDOCHONDRAL OSSIFICATION; GELATIN HYDROGEL (GH); IN-VITRO; IN-VIVO; RAT MODELS; REGENERATION (RENOVATING);

TISSUE;

COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CONNECTIVE TISSUE GROWTH FACTOR 2; GELATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE MARROW CELL; BONE MINERALIZATION; BONE REGENERATION; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; STROMA CELL; SUSTAINED DRUG RELEASE;

RATTUS;

EID: 45549107295     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2007.0167     Document Type: Article

References (40)

1. Chapman, M.W., Buchholz, R., and Cornell, C. Treatment of acute fractures with a collagen-calcium phosphate graft material. J Bone Joint Surg (Am) 79, 495-502, 1997.
2. Bohner, M. Physical and chemical aspects of calcium phosphates used in spinal surgery. Eur Spine J 10, 114-121, 2001.
3. Dorozhkin, S.V., and Epple, M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed Engl 41, 3130-3146, 2002.
4. Tadic, D., and Epple, M. A thorough physicochemical characterization of 14 calcium phosphate-based bone substitution materials in comparison to natural bone. Biomaterials 25, 987-994, 2004.
5. Komaki, H., Tanaka, T., Chazono, M., and Kikuchi, T. Repair of segmental bone defects in rabbit tibiae using a complex of beta-tricalcium phosphate, type I collagen, and fibroblast growth factor-2. Biomaterials 27, 5118-5126, 2006.
6. Jeon, O., Song, S.J., Kang, S.W., Putnam, A.J., and Kim, B.S. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold. Biomaterials 28, 2763-2771, 2007.
7. Karl, H.K., and Carl, K.H. Mesenchymal stem cell and bone regeneration. Vet Surg 35, 232-242, 2006.
8. Mengchun, Q.I., Jing, H.U., Shujuan, Z.O.U., Haixian, Z.H.O.U., and Lichi, H.A.N. Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg 34, 283-289, 2006.
9. Schnettler, R., Alt, V., Dingeldein, E., Pfefferle, H., Kilian, O., Meyer, C., Heiss, C., and Wenisch, S. Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants. Biomaterials 24, 4603-4608, 2003.
10. Tabata, Y., and Ikada, Y. Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 20, 2169-2175, 1999.
11. Nakase, T., and Yoshikawa, H. Potential roles of bone morphogenetic proteins (BMPs) in skeletal repair and regeneration. J Bone Miner Metab 24, 425-433, 2006.
12. Liu, H.W., Chen, C.H., Tsai, C.L., Lin, I.H., and Hsiue, G.H. Heterobifunctional poly(ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cell differentiation and osteogenesis. Tissue Eng 13, 1113-1124, 2007.
13. Bradham, D.M., Igarashi, A., Potter, R.L., and Grotendorst, G.R. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 114, 1285-1294, 1991.
14. Moussad, E., and Brigstock, D.R. Connective tissue growth factor: what's in a name? Mol Genet Metab 71, 276-292, 2000.
15. Takigawa, M., Nakanishi, T., Kubota, S., and Nishida, T. Role of CTGF/Hcs24/ecogenin in skeletal growth control. J Cell Physiol 194, 256-266, 2003.
16. Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kushibiki, T., Tabata, Y., and Takigawa, M. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res 19, 1308-1319, 2004.
17. Kubota, S., and Takigawa, M. Role of CCN2/CTGF/Hcs24 in bone growth. In: Jeon, K.W., ed. International Review of Cytology, vol. 257. London, UK: Academic Press/Elsevier, 2007, pp. 1-41.
18. Bork, P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 327, 125-130, 1993.
19. Lau, L.F., and Lam, S.C.T. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 248, 44-57, 1999.
20. Brigstock, D.R., Goldschmeding, R., Katsube, K., Lam, S.C.-T., Lau, L.F., Lyons, K., Naus, C., Perbal, B., Riser, B., Takigawa, M., and Yeger, H. Proposal for a unified CCN nomenclature. Mol Pathol 56, 127-128, 2003.
21. Perbal, B. CCN proteins: multifunctional signalling regulators. Lancet 363, 62-64, 2004.
22. Perbal, B., and Takigawa, M. CCN Protein - A New Family of Cell Growth and Differentiation Regulators. London, UK: Imperial College Press, 2005.
23. Frazier, K., Williams, S., Kothapalli, D., Klapper, H., and Grotendorst, G.R. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 107, 404-411, 1996.
24. Kikuchi, K., Kadono, T., Ihn, H., Sato, S., Igarashi, A., Nakagawa, H., Tamaki, K., and Takehara, K. Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-beta 1. J Invest Dermatol 105, 128-132, 1995.
25. Nakanishi, T., Nishida, T., Shimo, T., Kobayashi, K., Kubo, T., Tamatani, T., Tezuka, K., and Takigawa, M. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 141, 264-273, 2000.
26. Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Kanyama, M., Kuboki, T., Tamatani, T., Tezuka, K., Takemura, M., Matsumura, T., and Takigawa, M. Connective tissue growth factor induces the proliferation, migration and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem 126, 137-145, 1999.
27. Nishida, T., Nakanishi, T., Asano, M., Shimo, T., and Takigawa, M. Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro. J Cell Physiol 184, 197-206, 2000.
28. Ono, M., Kubota, S., Fujisawa, T., Sonoyama, W., Kawaki, H., Akiyama, K., Oshima, M., Nishida, T., Yoshida, Y., Suzuki, K., Takigawa, M., and Kuboki, T. Promotion of attachment of human bone marrow stromal cells by CCN2. Biochem Biophys Res Commun 357, 20-25, 2007.
29. Ono, M., Kubota, S., Fujisawa, T., Sonoyama, W., Kawaki, H., Akiyama, K., Oshima, M., Nishida, T., Yoshida, Y., Suzuki, K., Takigawa, M., and Kuboki, T. Promotion of hydroxyapatite-associated, stem cells-based bone regeneration by CCN2. Cell Transplant 2008 (In press).
30. Nakata, E., Nakanishi, T., Kawai, A., Asaumi, K., Yamaai, T., Asano, M., Nishida, T., Mitani, S., Inoue, H., and Takigawa, M. Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing. Bone 31, 441-447, 2002.
31. Kubota, S., Kawata, K., Yanagita, T., Doi, H., Kitoh, T., and Takigawa, M. Abundant retention release of connective tissue growth factor (CTGF/CCN2) by platelets. J Biochem 136, 279-282, 2004.
32. Cicha, I., Garlichs, C.D., Daniel, W.G., and Goppelt-Struebe, M. Activated human platelets release connective tissue growth factor. Thromb Haemost 91, 755-760, 2004.
33. Hokugo, A., Ozeki, M., Kawakami, O., Sugimoto, K., Mushimoto, K., Morita, S., and Tabata, Y. Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel. Tissue Eng 11, 1224-1233, 2005.
34. Inoue, A., Takahashi, K.A., Arai, Y., Tonomura, H., Sakao, K., Saito, M., Fujioka, M., Fujiwara, H., Tabata, Y., and Kubo, T. The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Arthritis Rheum 54, 264-270, 2006.
35. Yamamoto, M., Takahashi, Y., and Tabata, Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 24, 4375-4383, 2003.
36. Kubota, S., Kawaki, H., Kondo, S., Yosimichi, G., Minato, M., Nishida, T., Hanagata, H., Miyauchi, A., and Takigawa, M. Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture. Biochimie 88, 1973-1981, 2006.
37. Tielinen, L., Manninen, M., Puolakkainen, P., Kellomäki, M., Töumälä, P., Rich, J., Seppälä, J., and Rokkanen, P. Inability of transforming growth factor-beta 1, combined with a bioabsorbable polymer paste, to promote healing of bone defects in the rat distal femur. Arch Orthop Trauma Surg 121, 191-196, 2001.
38. Moritani, N.H., Kubota, S., Sugahara, T., and Takigawa, M. Comparable response of ccn1 and ccn2 genes upon arthritis: an in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines. Cell Commun Signal 3, 6, 2005.
39. Ball, D.K., Moussad, E.E., Rageh, M.A., Kemper, S.A., and Brigstock, D.R. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction 125, 271-284, 2003.
40. Shimo, T., Kubota, S., Yoshioka, N., Ibaragi, S., Isowa, S., Eguchi, T., Sasaki, A., and Takigawa, M. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res 21, 1045-1059, 2006.