The non-catalytic N-terminal extension of formylglycine-generating enzyme is required for its biological activity and retention in the endoplasmic reticulum

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11556-11564

  Mariappan, Malaiyalam ^a   Gande, Santosh Lakshmi ^a   Radhakrishnan, Karthikeyan ^b   Schmidt, Bernhard ^a   Dierks, Thomas ^b   Von Figura, Kurt ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOACTIVITY; CELL MEMBRANES; ENZYMES; RESTORATION;

CYSTEINE RESIDUES; ENDOPLASMIC RETICULUM; ENZYMATIC ACTIVITIES; FORMYLGLYCINE-GENERATING ENZYMES; FUSION PROTEINS; HYBRID CONSTRUCTS; N-TERMINAL EXTENSION; PARTIAL RESTORATION;

CATALYST ACTIVITY;

CYSTEINE; FORMYLGLYCINE GENERATING ENZYME; GLYCINE; HYBRID PROTEIN; POLYPEPTIDE; SECRETORY PROTEIN; SULFATASE; TETRAPEPTIDE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; N FORMYLGLYCINE; N-FORMYLGLYCINE; PEPTIDE; SUMF1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; BIOLOGICAL MODEL; CATALYSIS; CELL CULTURE; CHEMISTRY; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

CATALYSIS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELLS, CULTURED; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCINE; HUMANS; MODELS, BIOLOGICAL; PEPTIDES; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SULFATASES;

EID: 45549103883     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707858200     Document Type: Article

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