Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 cells) via a protein kinase C- And mitogen activated protein kinase-dependent mechanism

Journal of Proteome Research

Volumn 7, Issue 4, 2008, Pages 1704-1711

  Tie, Lu ^a   Zhang, Jian Zhao ^a   Lin, Yan Hua ^a   Su, Tian Hao ^a   Li, Yu Hua ^a   Wu, Hong Li ^a   Zhang, You Yi ^b   Yu, He Ming ^c   Li, Xue Jun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

Author keywords

AP18; ERK; Microtubule associated protein 2c; PC12 cells; Phosphorylation, 2 adrenoceptor; PKC

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; CATECHOLAMINE; CLONIDINE; CYTOSKELETON PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN 2C; MITOGEN ACTIVATED PROTEIN KINASE; NOCODAZOLE; PROTEIN KINASE C; UNCLASSIFIED DRUG; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BENZOPHENANTHRIDINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHELERYTHRINE; FLAVONOID; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, RAT; PROTEIN KINASE INHIBITOR; SERINE; YOHIMBINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NERVE CELL PLASTICITY; NEURITE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; IMMUNOBLOTTING; METABOLISM; MICROTUBULE; PHOSPHORYLATION; RAT;

RATTUS;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BENZOPHENANTHRIDINES; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; IMMUNOBLOTTING; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MODELS, BIOLOGICAL; NEURITES; NOCODAZOLE; PC12 CELLS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SERINE; YOHIMBINE;

EID: 45549101833     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr700711s     Document Type: Article

References (39)

1. Hein, L. Adrenoceptors and signal transduction in neurons. Cell Tissue Res. 2006, 326 (2), 541-551.
2. Hoffman, W. E.; Kochs, E.; Werner, C; Thomas, C; Albrecht, R. F. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology 1991, 75 (2), 328-332.
3. Halonen, T.; Kotti, T.; Tuunanen, J.; Toppinen, A.; Miettinen, R.; Riekkinen, P. J. Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. Brain Res. 1995, 693 (1-2), 217-224.
4. Laudenbach, V.; Mantz, J.; Lagercrantz, H.; Desmonts, J. M.; Evrard, P.; Gressens, P. Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. Anesthesiology 2002, 96 (1), 134-141.
5. Handy, D. E.; Flordellis, C. S.; Bogdanova, N. N.; Bresnahan, M. R.; Gavras, H. Diverse tissue expression of rat alpha 2-adrenergic receptor genes. Hypertension 1993, 21 (6 Pt. 1), 861-865.
6. Winzer-Serhan, U. H.; Leslie, F. M. Alpha2B adrenoceptor mRNA expression during rat brain development. Brain Res. Dev. Brain Res. 1997, 100 (1), 90-100.
7. Winzer-Serhan, U. H.; Raymon, H. K.; Broide, R. S.; Chen, Y.; Leslie, F. M. Expression of alpha 2 adrenoceptors during rat brain development-II. Alpha 2C messenger RNA expression and [3H)rauwolscine binding. Neuroscience 1997, 76 (1), 261-272.
8. Winzer-Serhan, U. H.; Raymon, H. K.; Broide, R. S.; Chen, Y.; Leslie, F. M. Expression of alpha 2 adrenoceptors during rat brain development-I. Alpha 2A messenger RNA expression. Neuroscience 1997, 76 (1), 241-260.
9. Civantos Calzada, B.; Aleixandre de Artinano, A. Alpha-adrenoceptor subtypes. Pharmacol. Res. 2001, 44 (3), 195-208.
10. Rowe, S. J.; Messenger, N. J.; Warner, A. E. The role of noradrenaline in the differentiation of amphibian embryonic neurons. Development 1993, 119 (4), 1343-1357.
11. Yamada, K. M.; Spooner, B. S.; Wessells, N. K. Axon growth: roles of microfilaments and microtubules. Proc. Natl. Acad. Sci. U.S.A. 1970, 66 (4), 1206-1212.
12. Kalcheva, N.; Albala, J.; O'Guin, K.; Rubino, H.; Garner, C.; Shafit-Zagardo, B. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (24), 10894-10898.
13. Kalcheva, N.; Shafit-Zagardo, B. Three unique 5′ untranslated regions are spliced to common coding exons of high- and low-molecular-weight microtubule-associated protein-2. J. Neurochem. 1995, 65 (4), 1472-1480.
14. Binder, L. I.; Frankfurter, A.; Kim, H.; Caceres, A.; Payne, M. R.; Rebhun, L. I. Heterogeneity of microtubule-associated protein 2 during rat brain development. Proc. Natl. Acad. Sci. U.S.A. 1984, 81 (17), 5613-5617.
15. Riederer, B.; Matus, A. Differential expression of distinct microtubule-associated proteins during brain development. Proc. Natl. Acad. Sci. U.S.A. 1985, 82 (17), 6006-6009.
16. Sanchez, C; Diaz-Nido, J.; Avila, J. Phosphorylation of microtubule- associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function. Prog. Neurobiol. 2000, 61 (2), 133-168.
17. Brugg, B.; Matus, A. Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells. J. Cell Biol. 1991, 114 (4), 735-743.
18. Audesirk, G.; Cabell, L.; Kern, M. Modulation of neurite branching by protein phosphorylation in cultured rat hippocampal neurons. Brain Res Dev Brain Res 1997, 102 (2), 247-60.
19. lohnson, G. V.; Jope, R. S. The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration. J. Neurosci. Res. 1992, 33 (4), 505-512.
20. Sanchez Martin, C; Diaz-Nido, J.; Avila, J. Regulation of a site- specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neurons. Neuroscience 1998, 87 (4), 861-870.
21. Greene, L. A.; Tischler, A. S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U.S.A. 1976, 73 (7), 2424-2428.
22. Davidkova, G.; Zhang, S. P.; Nichols, R. A.; Weiss, B. Reduced level of calmodulin in PC12 cells induced by stable expression of calmodulin antisense RNA inhibits cell proliferation and induces neurite outgrowth. Neuroscience 1996, 75 (4), 1003-1019.
23. Acosta, R.; Montanez, C; Fuentes-Mera, L.; Gonzalez, E.; Gomez, P.; Quintero-Mora, L.; Mornet, D.; Alvarez-Salas, L. M.; Cisneros, B. Dystrophin Dp71 is required for neurite outgrowth in PC 12 cells. Exp. Cell Res. 2004, 296 (2), 265-275.
24. Kindler, S.; Schulz, B.; Goedert, M.; Garner, C. C. Molecular structure of microtubule-associated protein 2b and 2c from rat brain. J. Biol. Chem. 1990, 265 (32), 19679-19684.
25. Garner, C. C; Matus, A. Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts. J. Cell Biol. 1988, 106 (3), 779-783.
26. Matus, A. Microtubule-associated proteins: their potential role in determining neuronal morphology. Annu. Rev. Neurosci. 1988, 11, 29-44.
27. Nunez, ). Differential expression of microtubule components during brain development. Dev. Neurosci. 1986, 8 (3), 125-141.
28. unez, J. Immature and mature variants of MAP2 and tau proteins and neuronal plasticity. Trends Neurosci. 1988, 11 (11), 477-479.
29. Hirokawa, N. Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr. Opin. Cell Biol. 1994, 6 (1), 74-81.
30. Mandelkow, E.; Mandelkow, E. M. Microtubules and microtubule- associated proteins. Curr. Opin. Cell Biol. 1995, 7 (1), 72-81.
31. Ebneth, A.; Drewes, G.; Mandelkow, E. M.; Mandelkow, E. Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Cell Motil. Cytoskeleton 1999, 44 (3), 209-224.
32. Murthy, A. S.; Flavin, M. Microtubule assembly using the microtubule-associated protein MAP-2 prepared in defined states of phosphorylation with protein kinase and phosphatase. Eur. J. Biochem. 1983, 137 (1-2), 37-46.
33. Riederer, B. M.; Draberova, E.; Viklicky, V.; Draber, P. Changes of MAP2 phosphorylation during brain development. J. Histochem. Cytochem. 1995, 43 (12), 1269-1284.
34. Khuchua, Z.; Wozniak, D. F.; Bardgett, M. E.; Yue, Z.; McDonald, M.; Boero, J.; Hartman, R. E.; Sims, H.; Strauss, A. W. Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal cal neuron architecture and alters contextual memory. Neuroscience 2003, 119(1), 101-111.
35. Philpot, B. D.; Lim, J. H.; Halpain, S.; Bninjes, P. C. Experience-dependent modifications in MAP2 phosphorylation in rat olfactory bulb. J. Neurosci. 1997, 17 (24), 9596-9604.
36. Ma, D.; Rajakumaraswamy, N.; Maze, M. alpha2-Adrenoceptor agonists: shedding light on neuroprotection. Br. Med. Bull. 2004, 71, 77-92.
37. Wheeler, L.; WoldeMussie, E.; Lai, R. Role of alpha-2 agonists in neuroprotection. Surv. Ophthalmol. 2003, 48 (Suppl. 1), S47-51.
38. Taraviras, S.; Olli-Lahdesmaki, T.; Lymperopoulos, A.; Chari-tonidou, D.; Mavroidis, M.; Kallio, J.; Scheinin, M.; Flordellis, C. Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptors. Eur. J. Cell Biol. 2002, 81 (6), 363-374.
39. Song, Z. M.; Abou-Zeid, O.; Fang, Y. Y. Alpha2a adrenoceptors regulate phosphorylation of microtubule-associated protein-2 in cultured cortical neurons. Neuroscience 2004, 123 (2), 405-418.