Naturally arising point mutations in non-essential domains of equine infectious anemia virus Rev alter Rev-dependent nuclear-export activity

Journal of General Virology

Volumn 89, Issue 4, 2008, Pages 1043-1048

  Sparks, Wendy O ^a   Dorman, Karin S ^a,b   Liu, Sijun ^a   Carpenter, Susan ^a,c  

^a IOWA STATE UNIVERSITY   (United States)

^b Iowa State University   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REV PROTEIN;

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EQUINE INFECTIOUS ANEMIA VIRUS; GENE FREQUENCY; GENETIC CONSERVATION; GENETIC VARIABILITY; IN VIVO STUDY; NONHUMAN; NUCLEAR EXPORT SIGNAL; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; VIRAL GENETICS; VIRUS INFECTION; ACTIVE TRANSPORT; ANIMAL; CELL NUCLEUS; GENETICS; HORSE; HORSE DISEASE; METABOLISM; PROTEIN TERTIARY STRUCTURE; VIROLOGY;

EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; EQUINE INFECTIOUS ANEMIA; GENE PRODUCTS, REV; HORSES; INFECTIOUS ANEMIA VIRUS, EQUINE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 45549098432     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83195-0     Document Type: Article

References (24)

1. Addo, M. M., Altfeld, M., Rosenberg, E. S., Eldridge, R. L., Phillips, M. N., Habeeb, K., Khatri, A., Brander, C. & Robbins, G. K., other authors & HIV Controller Study Collaboration (2001). The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. Proc Natl Acad Sci U S A 98, 1781-1786.
2. Alexandersen, S. & Carpenter, S. (1991). Characterization of variable regions in the envelope and S3 open reading frame of equine infectious anemia virus. J Virol 65, 4255-4262.
3. + T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol 79, 13239-13249.
4. Baccam, P., Thompson, R. J., Li, Y., Sparks, W. O., Belshan, M., Dorman, K. S., Wannemuehler, Y., Oaks, J. L., Cornette, J. L. & Carpenter, S. (2003). Subpopulations of equine infectious anemia virus Rev coexist in vivo and differ in phenotype. J Virol 77, 12122-12131.
5. Belshan, M., Harris, M. E., Shoemaker, A. E., Hope, T. J. & Carpenter, S. (1998). Biological characterization of Rev variation in equine infectious anemia virus. J Virol 72, 4421-4426.
6. Belshan, M., Baccam, P., Oaks, J. L., Sponseller, B. A., Murphy, S. C., Cornette, J. & Carpenter, S. (2001). Genetic and biological variation in equine infectious anemia virus Rev correlates with variable stages of clinical disease in an experimentally infected pony. Virology 279, 185-200.
7. Bobbitt, K. R., Addo, M. M., Altfeld, M., Filzen, T., Onafuwa, A. A., Walker, B. D. & Collins, K. L. (2003). Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing. Immunity 18, 289-299.
8. Coffin, J. M. (1995). HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
9. Cosson, P. (1996). Direct interaction between the envelope and matrix proteins of HIV-1. EMBO J 15, 5783-5788.
10. Dubay, J. W., Roberts, S. J., Hahn, B. H. & Hunter, E. (1992). Truncation of the human immunodeficiency virus type 1 transmembrane glycoprotein cytoplasmic domain blocks virus infectivity. J Virol 66, 6616-6625.
11. Freed, E. O. & Martin, M. A. (1996). Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions. J Virol 70, 341-351.
12. Fridell, R. A., Partin, K. M., Carpenter, S. & Cullen, B. R. (1993). Identification of the activation domain of equine infectious anemia virus rev. J Virol 67, 7317-7323.
13. Fultz, P. N., Vance, P. J., Endres, M. J., Tao, B., Dvorin, J. D., Davis, I. C., Lifson, J. D., Montefiori, D. C., Marsh, M. & other authors (2001). In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. J Virol 75, 278-291.
14. Gabuzda, D. H., Lever, A., Terwilliger, E. & Sodroski, J. (1992). Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins. J Virol 66, 3306-3315.
15. Harris, M. E., Gontarek, R. R., Derse, D. & Hope, T. J. (1998). Differential requirements for alternative splicing and nuclear export functions of equine infectious anemia virus Rev protein. Mol Cell Biol 18, 3889-3899.
16. Kalia, V., Sarkar, S., Gupta, P. & Montelaro, R. C. (2003). Rational site-directed mutations of LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation. J Virol 77, 3634-3646.
17. Lee, S. J., Hu, W., Fisher, A. G., Looney, D. J., Kao, V. F., Mitsuya, H., Ratner, L. & Wong-Staal, F. (1989). Role of the carboxy-terminal portion of the HIV-1 transmembrane protein in viral transmission and cytopathogenicity. AIDS Res Hum Retroviruses 5, 441-449.
18. Lee, J.-H., Murphy, S. C., Belshan, M., Sparks, W. O., Wannemuehler, Y., Liu, S., Hope, T. J., Dobbs, D. & Carpenter, S. (2006). Characterization of functional domains of equine infectious anemia virus Rev suggests a bipartite RNA-binding domain. J Virol 80, 3844-3852.
19. Leroux, C., Issel, C. J. & Montelaro, R. C. (1997). Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony. J Virol 71, 9627-9639.
20. Liu, Y., McNevin, J., Zhao, H., Tebit, D. M., Troyer, R. M., McSweyn, M., Ghosh, A. K., Shriner, D., Arts, E. J. & other authors (2007). Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape. J Virol 81, 12179-12188.
21. Mancuso, V. A., Hope, T. J., Zhu, L., Derse, D., Phillips, T. & Parslow, T. G. (1994). Posttranscriptional effector domains in the rev proteins of feline immunodeficiency virus and equine infectious anemia virus. J Virol 68, 1998-2001.
22. Mealey, R. H., Zhang, B., Leib, S. R., Littke, M. H. & McGuire, T. C. (2003). Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus. Virology 313, 537-552.
23. Shacklett, B. L., Weber, C. J., Shaw, K. E. S., Keddie, E. M., Gardner, M. B., Sonigo, P. & Luciw, P. A. (2000). The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques. J Virol 74, 5836-5844.
24. Sponseller, B. A., Sparks, W. O., Wannemuehler, Y., Li, Y., Antons, A. K., Oaks, J. L. & Carpenter, S. (2007). Immune selection of equine infectious anemia virus env variants during the long-term inapparent stage of disease. Virology 363, 156-165.