Concurrent megakaryocyte and erythroid chronic myelogenous leukemia blast crisis

Archives of Pathology and Laboratory Medicine

Volumn 132, Issue 6, 2008, Pages 1021-1025

  Westfall, Danielle E ^a,c   Zhang, Ling ^a   Song, Sophie ^b   Lee, Stephen ^a  

^a Cedars Sinai Medical Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; HYDROXYUREA; IMATINIB; ANTINEOPLASTIC AGENT; LEUKOCYTE ANTIGEN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

AGED; ARTICLE; BLAST CELL CRISIS; CASE REPORT; CHRONIC MYELOID LEUKEMIA; CLONE; CYTOGENETICS; DISEASE COURSE; ERYTHROID CELL; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN TISSUE; LEUKOCYTOSIS; MALE; MEGAKARYOCYTE; MYELOBLAST; MYELODYSPLASIA; MYELOFIBROSIS; ERYTHROCYTE; FATALITY; IMMUNOPHENOTYPING; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; BLAST CRISIS; ERYTHROCYTES; FATAL OUTCOME; FLOW CYTOMETRY; FUSION PROTEINS, BCR-ABL; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MEGAKARYOCYTES; PIPERAZINES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 45549089825     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Vardiman JW, Imbert M, Pierre R. Chronic myelogenous leukaemia. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001:20-26. World Health Organization Classification of Tumours.
2. Hernandez JM, Gonzalez-Sarmiento R, Martin C, et al. Immunophenotypic, genomic and clinical characteristics of blast crisis of chronic myelogenous leukemia. Br J Haematol. 1991;79:408-414.
3. Ekblom M, Borgstrom G, von Willebrand E, Gahmberg CG, Vuopio P, Andersson LC. Erythroid blast crisis in chronic myelogenous leukemia. Blood. 1983; 62:591-596.
4. Rosenthal S, Canellos G, Gralnick H. Erythroblastic transformation of chronic granulocytic leukemia. Am J Med. 1977;63:116-124.
5. Saikia T, Advani S, Dasgupta A, et al. Characterization of blast cells during blastic phase of chronic myeloid leukemia by immunophenotyping - experience in 60 patients. Leukemia Res. 1988;12:499-506.
6. Ryo R, Adachi M, Sugano W, et al. Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia. Cancer. 1991;67:960-964.
7. McFarlane R, Tseih S. Detection of BCR/ABL fusion product in normoblasts in a case of chronic myelogenous leukemia. Am J Surg Pathol. 2004;28:1240-1244.
8. Calabretta B, Perrotti D. The biology of CML blast crisis. Blood. 2004;103: 4010-4022.
9. Nimer SD, MacGrogan D, Jhanwar S, Alvarez S. Chromosome 19 abnormalities are commonly seen in AML, M7. Blood. 2002;100:3838.
10. Yamamoto K, Nakamura Y, Arai H, et al. Triple Philadelphia chromosomes with major-BCR rearrangement in hypotriploid erythroleukemia. Eur J Haematol. 2000;65:182-187.
11. Gorczyca W. Flow Cytometry in Neoplastic Hematology: Morphologic-immunophenotypic Correlation. London, England: Taylor & Francis; 2006:51-63.
12. Pelloso LA, Baiocchi OC, Chauffaile ML, Yamamoto M, HungriaVT, Bordin JO. Megakaryocyte blast crisis as a first presentation of chronic myeloid leukemia. Eur J Haematol. 2002;69:58-61.
13. Anand M, Kumar R, Singh S. Megakaryoblastic lineage of peripheral blood blasts of CML blast crisis identified by budding dysplastic platelets. Am J Hematol. 2004;75:239-240.
14. Tsuyuoka R, Takahashi T, Suzuki A, et al. A newly established megakar-yoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles. Stem Cells. 1995;13:54-64.
15. Amemiya N, Yatomi Y, Yanagi M, et al. Mixed blast crisis of chronic myelogenous leukemia involving minimally differentiated myeloblast and mega-karyoblast lineages. Lab Hematol. 2004;10:254-255.
16. Wu CD, Medeiros LJ, Miranda RN, Mark HP, Rintels P. Chronic myeloid leukemia manifested during megakaryoblastic crisis. Southern Med J. 1996;89: 422-427.
17. Giles FJ, Cortes JE, Kantarjian HM, et al. Accelerated and blastic phases of chronic myelogenous leukemia. Hematol Oncol Clin North Am. 2004;18:753-774.