Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the revised bethesda guidelines

International Journal of Colorectal Disease

Volumn 23, Issue 8, 2008, Pages 801-806

  Urso, E ^a   Pucciarelli, S ^a,d   Agostini, M ^a   Maretto, I ^a   Mescoli, C ^a   Bertorelle, R ^b   Viel, A ^c   Rugge, M ^a   Nitti, D ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d Clinica Chirurgica II   (Italy)

Author keywords

Colorectal cancer; Colorectal cancer (HNPCC); Hereditary non polyposis; Inherited gastrointestinal syndromes; Microsatellite instability

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2;

ADULT; AGE; AGED; ARTICLE; CANCER PATIENT; CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; ITALY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT; TUMOR LOCALIZATION; UNIVERSITY HOSPITAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; DNA, NEOPLASM; FEMALE; GENETIC SCREENING; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PRACTICE GUIDELINES AS TOPIC; RECTAL NEOPLASMS;

EID: 45449110394     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-008-0484-2     Document Type: Article

References (14)

1. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB (1998) Incidence and functional consequences of MLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95:6870-6875
2. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116:1453-1456
3. Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J, LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency. JAMA 293:1979-1985
4. Vasen HFA (2005) Clinical description of the Lynch syndrome (hereditary non polyposis colorectal cancer [HNPCC]). Familial Cancer 4:219-225
5. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. Natl Cancer Inst 96:261-268
6. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Nakagawa H, Sotamaa K, Prior TW, Westman J, Panescu J, Fix D, Lockman J, Comeras I, de la Chapelle A (2005) Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 352:1851-1860
7. Shashidharan M, Smyrk T, Lin KM, Ternent CA, Thorson AG, Blatchford GJ, Christensen MA, Lynch HT (1999) Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population. Dis Colon Rectum 42:722-726
8. Park JG, Vasen HF, Park KJ, Peltomaki P, Ponz de Leon M, Rodriguez-Bigas MA, Lubinski J, Beck NE, Bisgaard ML, Miyaki M, Wijnen JT, Baba S, Lynch HT (1999) Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. Dis Colon Rectum 42:710-715
9. Ruo L, Cellini C, La-Calle JP Jr, Murray M, Thaler HT, Quan SH, Guillem JG (2001) Limitations of family cancer history assessment at initial surgical consultation. Dis Colon Rectum 44:98-103
10. Vasen HF, Möslein G, Alonso A, Bernstein I, Bertario L, Blanco I, Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Møller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J (2007) Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis colorectal cancer). J Med Genet 44:353-362
11. Peterlongo P, Mitra N, de Abajo AS, de la Hoya M, Bassi C, Bertario L, Radice P, Glogowski E, Nafa K, Caldes T, Offit K, Ellis NA (2006) Increased frequency of disease-causing MYH mutations in colon cancer families. Carcinogenesis 27:2243-2249
12. Qing SH, Rao KY, Jiang HY, Wexner SD (2003) Racial differences in the anatomical distribution of colorectal cancer: A study of differences between American and Chinese patients. World J Gastroenterol 9:721-725
13. Nelson RL, Dollear T, Freels S, Persky V (1997) The relation of age, race, and gender to the subsite location of colorectal carcinoma. Cancer 80:193-197
14. Lindblom A (2001) Different mechanisms in the tumourigenesis of proximal and distal colon cancers. Curr Opin Oncol 13:63-69