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45449118393
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Part 168 in the series, Studies on novel synthetic methodologies.
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Part 168 in the series, Studies on novel synthetic methodologies.
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33845558092
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3 (3mmol) was added. The mixture was stirred under reflux and the progress of the reaction was monitored by TLC. After completion the solvent was evaporated under reduced pressure. The product was extracted with EtOAc (2 × 10 mL), concentrated and chromatographed over silica gel to obtain the corresponding allyl chloride.
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3 (3mmol) was added. The mixture was stirred under reflux and the progress of the reaction was monitored by TLC. After completion the solvent was evaporated under reduced pressure. The product was extracted with EtOAc (2 × 10 mL), concentrated and chromatographed over silica gel to obtain the corresponding allyl chloride.
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The spectral (1HNMR and MS) data of some representative products are given below. 3c: 1HNMR (200 MHz, CDCl3, δ 8.32 (2H, d, J, 8.0Hz, 7.89 (1H, s, 7.70 (2H, d, J, 8.0Hz, 4.35 (2H, s, 4.32 (2H, q, J, 7.0Hz, 1.37 (3H, t, J, 8.0Hz, FABMS: m/z 281, 283, 285 [M, Na, 3g: 1HNMR (200 MHz, CDCl3, δ 7.82 (1H, s, 7.55 (2H, d, J, 8.0Hz, 6.98 (2H, d, J, 8.0Hz, 4.51 (2H, s, 3.86 (6H, s, FABMS: m/z 263, 265 [M, Na, 3i: 1HNMR (200 MHz, CDCl3, δ 7.51 (2H, d, J, 8.0Hz, 7.41 (2H, d, J, 8.0Hz, 7.24 (1H, s, 4.39 (2H, s, 3.88 (3H, s, FABMS: m/z 278, 280 [M, Na, 4k: 1HNMR (200MHz, CDCl3, δ 7.79 (2H,d, J, 8.0 Hz, 7.44 (2H, d, J, 8.0Hz, 7.18 (1H, s, 4.28 2H, s, FABMS: m/z 234, 236, 238 [M, Na
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+.
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