Protective Effects of FR167653 on Chronic Allograft Nephropathy by Inhibiting p38 MAPK in Rats

Transplantation Proceedings

Volumn 40, Issue 5, 2008, Pages 1685-1689

  Tan, H B ^a   Feng, Y ^b   Liu, M ^c   Wu, Y C ^d  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; CYCLOSPORIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; FISCHER 344 RAT; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LEWIS RAT; MALE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; PROTEINURIA; RAT;

ANIMALS; CHRONIC DISEASE; CREATININE; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEINURIA; PYRAZOLES; PYRIDINES; RATS; RATS, INBRED F344; RATS, INBRED LEW; TRANSPLANTATION, HOMOLOGOUS;

EID: 45449084220     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2008.01.073     Document Type: Article

References (20)

1. Moreso F., Ibernon M., Goma M., et al. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 6 (2006) 747
2. Nankivell B.J., and Chapman J.R. Chronic allograft nephropathy: current concepts and future directions. Transplantation 81 (2006) 643
3. Waanders F., van den Berg E., Nagai R., et al. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats. Nephrol Dial Transplant 23 (2008) 518
4. Ramesh G., and Reeves W.B. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol 289 (2005) F166
5. Wada T., Yokoyama H., Furuichi K., et al. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). FASEB J 10 (1996) 1418
6. Azuma H., Wada T., Gotoh R., et al. Combined therapy of FR167653 and CsA significantly prolonged animal survival in rat renal allografts. Transplantation 76 (2003) 1029
7. Zhang W., Liu M., Wu Y.C., et al. Protective effects of atorvastatin on chronic allograft nephropathy in rats. J Surg Res 143 (2007) 428
8. Racusen L.C., Solez K., Colvin R.B., et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 55 (1999) 713
9. Yamagishi S., Yamada M., Hatanaka H., et al. p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. J Biol Chem 276 (2001) 5129
10. Park J., Ha H., Seo J., et al. Mycophenolic acid inhibits platelet-derived growth factor-induced reactive oxygen species and mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Am J Transplant 4 (2004) 1982
11. Wu M.S. From bedside to bench drug-induced tubulointerstitial disease cyclosporine nephropathy study from models of cultured renal epithelial cells. Chang Gung Med J 30 (2007) 7
12. Raingeaud J., Gupta S., Rogers J.S., et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270 (1995) 7420
13. Zhang X., Cao Y., Meng A., et al. Graft expression of p38 and tumor necrosis factor-alpha in heart transplantation in rats. Prog Transplant 12 (2002) 309
14. Djamali A., Reese S., Oberley T., et al. Heat shock protein 27 in chronic allograft nephropathy: a local stress response. Transplantation 79 (2005) 1645
15. Isaka Y., Fujiwara Y., Ueda N., et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 92 (1993) 2597
16. Hu B., Wu Z., and Phan S.H. Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression. Am J Respir Cell Mol Biol 29 (2003) 397
17. Stambe C., Atkins R.C., Tesch G.H., et al. The role of p38 alpha mitogen-activated protein kinase activation in renal fibrosis. J Am Soc Nephrol 15 (2004) 370
18. Stambe C., Atkins R.C., Tesch G.H., et al. Blockade of p38 alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. J Am Soc Nephrol 14 (2003) 338
19. Koshikawa M., Mukoyama M., Mori K., et al. Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol 16 (2003) 2690
20. Lee J.C., Kassis S., Kumar S., et al. p38 mitogenactivated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacol Ther 82 (2003) 389