Reduction of carbonyl compounds by lanthanide metal/2-propanol: In-situ generation of samarium isopropyloxide for stereoselective Meerwein-Ponndorf- Verley reduction

European Journal of Organic Chemistry

Volumn , Issue 13, 2004, Pages 2863-2867

  Fukuzawa, Shin Ichi ^a   Nakano, Narihito ^a   Saitoh, Takahide ^a  

^a CHUO UNIVERSITY   (Japan)

Author keywords

Lanthanides; Meerwein Ponndorf Verley reduction; Reductions; Samarium; Samarium alkoxide

Indexed keywords

1 PHENYLETHANOL; 2 PROPANOL; ACETOPHENONE; ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; CARBONYL DERIVATIVE; CESIUM; CYCLOHEXANONE DERIVATIVE; IODINE; KETONE DERIVATIVE; LANTHANIDE; LANTHANUM; METAL; SAMARIUM; YTTERBIUM;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHIRALITY; MEERWEIN PONNDORF VERLEY REDUCTION; REACTION ANALYSIS; REDUCTION KINETICS; STEREOCHEMISTRY; SUBSTITUTION REACTION;

EID: 4544384173     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ejoc.200400030     Document Type: Article

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42. 2CDOH (99.8%), and obtained a > 98% deuterated 1-phenylethanol, PhCD(OH)Me. This result suggests that hydride transfer occurs from the samarium isopropyloxide.
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