Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC

Acta Pharmacologica Sinica

Volumn 25, Issue 9, 2004, Pages 1118-1123

  Liu, Jian Xun ^a   Cong, Wei Hong ^a   Xu, Li ^a   Wang, Jian Nong ^a  

^a XIYUAN HOSPITAL   (China)

Author keywords

Acetylcholine; Amyloid beta protein; Ginkgo biloba; Ginseng; High pressure liquid chromatography

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; DISODIUM HYDROGEN PHOSPHATE; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; OCTANE; PALLADIUM; SULFONIC ACID DERIVATIVE; TETRAMETHYLAMMONIUM CHLORIDE;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DIAGNOSTIC ACCURACY; ELECTROCHEMICAL DETECTION; ELECTRODE; EXTRACTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMOBILIZED ENZYME REACTOR; LINEAR REGRESSION ANALYSIS; MALE; NONHUMAN; PH MEASUREMENT; RAT; SOLID STATE;

ACETYLCHOLINE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; BRAIN INJURIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; GINKGO BILOBA; MALE; PANAX; RATS; RATS, SPRAGUE-DAWLEY;

EID: 4544342873     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of β amyloid and protection by substance P. Proc Natl Acad Sci USA 1991; 88: 7247-51.
2. Maurice T, Lockhart BP, Privat A. Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 1996; 706: 181-93.
3. Geula C, Wu CK, Saroff DM, Lorenzo A, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 1998; 4: 827-31.
4. Sramek JJ, Anand R, Wardle TS, Irwin P, Hartman RD, Cutler NR. Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease. Life Sci 1996; 58: 1201-7.
5. Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 1998; 50: 136-45.
6. Jenden DJ, Roch M, Booth RA. Simultaneous measurement of endogenous and deuterium-labeled tracer variants of choline and acetylcholine in subpicomole quantities by gas chromatography-mass spectrometry. Anal Biochem 1973; 55: 438-48.
7. Potter PE, Meek JL, Neff NH. Acetylcholine and choline in neuronal tissue measured by HPLC with electrochemical detection. J Neurochem 1983; 41: 188-94.
8. Tsai HT. Separation methods used in the determination of choline and acetylcholine. J Chromatogr B Biomed Sci Appl 2000; 747: 111-22.
9. Coyle JT, Price DL, DeLong MR. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 1983; 219: 1184-90.
10. Collerton D. Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 1986; 19: 1-28.
11. de Boer P, Westerink BH, Horn AS. The effect of acetylcholinesterase inhibition of the release of acetylcholine from the striatum in vivo: interaction with autoreceptor response. Neurosci Lett 1990; 116: 357-60.
12. Greaney MD, Marshall DL, Bailey BA, Acworth IN. Improved method for the routine analysis of acetylcholine release in vivo: quantitation in the presence and absence of esterase inhibitor. J Chromatogr 1993; 622: 125-35.
13. Tsai TR, Cham TM, Chen KC, Chen CF, Tsai TH. Determination of acetylcholine by on-line microdialysis coupled with pre- and post-microbore column enzyme reactors with electrochemical detection. J Chromatogr B Biomed Appl 1996; 678: 151-5.