Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Angewandte Chemie - International Edition

Volumn 43, Issue 9, 2004, Pages 1129-1132

  Sharma, Pankaz K ^a   Kevorkiants, Rouslan ^a   De Visser, Sam P ^a   Kumar, Devesh ^a   Shaik, Sason ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Density functional calculations; Enzyme catalysis; Enzyme models; Heme proteins; Oxygenation

Indexed keywords

DEGRADATION; ENZYMES; HYDROXYLATION;

CYTOCHROMES; HEME SPECIES; HEME-OXYGENASE (HO); PORPHYRIN RINGS;

PORPHYRINS;

CYTOCHROME P450; HEME OXYGENASE; HYDROXYL GROUP; PORPHYRIN;

ARTICLE; CHEMICAL REACTION; COMPARATIVE STUDY; DEGRADATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HEME; HEME OXYGENASE (DECYCLIZING); HYDROXYLATION; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXYGEN; PORPHYRINS; WATER;

EID: 4544321757     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352943     Document Type: Article

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