Molecular design of cholesterols as inhibitors of DNA polymerase α

Journal of Medicinal Chemistry

Volumn 47, Issue 20, 2004, Pages 4971-4974

  Oshige, Masahiko ^a,c   Kuramochi, Kouji ^a   Ohta, Keisuke ^a   Ogawa, Akitsu ^a   Kuriyama, Hiroki ^b   Sugawara, Fumio ^a   Kobayashi, Susumu ^a   Sakaguchi, Kengo ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b Tama Biochemical Co Ltd   (Japan)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (CHOLESTANYL)ACETIC ACID; 2 (CHOLESTERYLOXY)ACETIC ACID; CHOLESTEROL DERIVATIVE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE ALPHA INHIBITOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULE; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHOLESTEROL; DNA; DNA POLYMERASE I; DNA TOPOISOMERASES; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544289292     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030553v     Document Type: Article

References (10)

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