Effects of acetylsalicylic acid on ascorbic acid concentrations in plasma, gastric mucosa, gastric juice and urine - A double-blind study in healthy subjects

International Journal of Clinical Pharmacology and Therapeutics

Volumn 42, Issue 9, 2004, Pages 481-487

  Schulz, H U ^a   Schurer M ^a   Krupp, S ^a   Dammann, H G ^b   Timm, J ^c   Gessner, U ^d  

^a Biopharmaceutical Analytics GmbH   (Germany)

^b Scientific Institute   (Germany)

^c UNIVERSITY OF BREMEN   (Germany)

^d BAYER AG   (Germany)

Author keywords

Acetylsalicylic acid interaction; Ascorbic acid concentrations; Gastric mucosa

Indexed keywords

ACETYLSALICYLIC ACID; ASCORBIC ACID; PLACEBO;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG TISSUE LEVEL; DRUG URINE LEVEL; ELDERLY CARE; FEMALE; GASTROINTESTINAL DISEASE; GASTROSCOPY; HUMAN; LONG TERM CARE; MALE; NORMAL HUMAN; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; STATISTICAL SIGNIFICANCE; STEADY STATE; STOMACH JUICE; STOMACH MUCOSA; STOMACH PH; STOMACH PROTECTION;

EID: 4544282310     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP42481     Document Type: Article

References (19)

1. Bässler K-H, Golly I, Loew D, Pietrzik K 1997 Vitamin-Lexikon für Ärzte, Apotheker und Ernährungswissenschaftler. Fischer, Stuttgart
2. Dyke GW, Craven JL, Hall R, Garner RC 1994 Effect of vitamin C supplementation on gastric mucosal DNA damage. Carcinogenesis 15: 291-295
3. Hall MG, Darling RC, Taylor FHL 1939 The vitamin C requirements in rheumatoid arthritis. Ann Intern Med 13: 415-423
4. Johansson U, Akesson B 1985 Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 55: 197-204
5. Loh HS, Watters K, Wilson CW 1973 The effects of aspirin on the metabolic availability of ascorbic acid in human beings. J Clin Pharmacol 13: 480-486
6. Loh HS, Wilson C W, Watters K 1975 The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 15: 36
7. Martini GA, Schmidt HA 1973 Magen. In: Siegenthaler W (ed) Klinische Pathophysiologie. Thieme, Stuttgart, pp 704-715
8. Moser U 1987 Uptake of ascorbic acid by leukocytes. Ann N Y Acad Sci 498: 200-215
9. O'Connor HJ, Schorah CJ, Habibzedah N, Axon AT, Cockel R 1989 Vitamin C in the human stomach: relation to gastric pH, gastroduodenal disease and possible sources. Gut 30: 436-442
10. Pohle T, Brzozowski T, Becker JC, Van der Voort IR, Markmann A, Konturek SJ, Moniczewski A, Domschke W, Konturek JW 2001 Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin C. Aliment Pharmacol Ther 15: 677-687
11. Rathbone BJ, Johnson AW, Wyatt JI, Kelleher J, Heatley RV, Losowsky MS 1989 Ascorbic acid: a factor concentrated in human gastric juice. Clin Sci (Lond) 76: 237-241
12. Rinehart JF, Greenberg LD, Baker F 1936 Reduced ascorbic acid contents of blood plasma in rheumatoid arthritis. Soc Exp Biol Med 35: 347
13. Sahud MA, Cohen RJ 1971 Effect of aspirin ingestion on ascorbic acid levels in rheumatoid arthritis. Lancet 1: 937-938
14. Schorah CJ 1997 Ascorbic acid metabolism and cancer in the human stomach. Acta Gastroenterol Belg 60: 217-219
15. Silbernagl S, Despopoulos A 1979 Taschenatlas der Physiologie. Thieme, Stuttgart, p 194
16. Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tompkins DS, Godwin P, Axon AT 1989 Ascorbic acid in the human stomach. Gastroenterology 97: 357-363
17. Waring AJ, Drake IM, Schorah CJ, White KL, Lynch DA, Axon AT, Dixon MF 1996 Ascorbic acid and total vitamin C concentrations in plasma, gastric juice and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut 38: 171-176
18. Waring AJ, Schorah CJ 1998 Transport of ascorbic acid in gastric epithelial cells in vitro. Clin Chim Acta 275: 137-149
19. Washko PW, Hartzell WO, Levine M 1989 Ascorbic acid analysis using high-performance liquid chromatography with colorimetric electrochemical detection. Anal Biochem 181: 276-282