Vitamin C pharmacokinetics of plain and slow release formulations in smokers

Clinical Nutrition

Volumn 23, Issue 5, 2004, Pages 1043-1050

  Viscovich, Michael ^a   Lykkesfeldt, Jens ^b   Poulsen, Henrik E ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

tocopherol; Ascorbic acid; Pharmacokinetics; Plain release; Slow release; Vitamin C

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CIGARETTE SMOKING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG MECHANISM; HUMAN; HUMAN EXPERIMENT; MALE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SLOW RELEASE FORMULATION; SMOKING HABIT;

ADULT; AGED; ALPHA-TOCOPHEROL; ANTIOXIDANTS; AREA UNDER CURVE; ARTERIOSCLEROSIS; ASCORBIC ACID; DELAYED-ACTION PREPARATIONS; DISEASE PROGRESSION; HUMANS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; SINGLE-BLIND METHOD; SMOKING;

EID: 4544251732     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2004.01.007     Document Type: Article

References (38)

1. Nishikimi M. Yagi K. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis Am J Clin Nutr 54 1991 1203S-1208S
2. Hornig D. Metabolism and requirements of ascorbic acid in man S Afr Med J 60 1981 818-823
3. Hodges R.E. Baker E.M. Hood J. Sauberlich H.E. March S.C. Experimental scurvy in man Am J Clin Nutr 22 1969 535-548
4. Salonen J.T. Nyyssonen K. Salonen R. et al. Antioxidant supplementation in atherosclerosis prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis J Intern Med 248 2000 377-386
5. Salonen R.M. Nyyssonen K. Kaikkonen J. et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the antioxidant supplementation in atherosclerosis prevention (ASAP) study Circulation 107 2003 947-953
6. Fang J.C. Kinlay S. Beltrame J. et al. Effect of Vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial Lancet 359 2002 1108-1113
7. Stephens N.G. Parsons A. Schofield P.M. Kelly F. Cheeseman K. Mitchinson M.J. randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) Lancet 347 1996 781-786
8. Vivekananthan D.P. Penn M.S. Sapp S.K. Hsu A. Topol E.J. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials Lancet 361 2003 2017-2023
9. Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 23-33.
10. Blot W.J. Li J.Y. Taylor P.R. et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population J Natl Cancer Inst 85 1993 1483-1492
11. The Alpha-tocopherol and Beta-carotene Cancer Prevention Group. The effect of vitamin E, Beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-tocopherol, Beta carotene Cancer Prevention Study Group. N Engl J Med 1994; 330: 1029-35.
12. Yusuf S. Dagenais G. Pogue J. Bosch J. Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators N Engl J Med 342 2000 154-160
13. GISSI-prevenzione Investigators. Dietary supplementation with N-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano Per Lo Studio Della Sopravvivenza Nell'Infarto Miocardico. Lancet 1999; 354: 447-55.
14. de Gaetano G. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project Lancet 357 2001 89-95
15. Waters D.D. Alderman E.L. Hsia J. et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial J Am Med Assoc 288 2002 2432-2440
16. Nyyssonen K. Poulsen H.E. Hayn M. et al. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation Eur J Clin Nutr 51 1997 154-163
17. Levine M. Conry-Cantilena C. Wang Y. et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance Proc Natl Acad Sci USA 93 1996 3704-3709
18. Lykkesfeldt J. Bolbjerg M.L. Poulsen H.E. Effect of smoking on erythorbic acid pharmacokinetics Br J Nutr 89 2003 667-671
19. Mangels A.R. Block G. Frey C.M. et al. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid J Nutr 123 1993 1054-1061
20. Jacob R.A. Omaye S.T. Skala J.H. Leggott P.J. Rothman D.L. Murray P.A. Experimental vitamin C depletion and supplementation in young men. Nutrient interactions and dental health effects Ann N Y Acad Sci 498 1987 333-346
21. Jacob R.A. Pianalto F.S. Agee R.E. Cellular ascorbate depletion in healthy men J Nutr 122 1992 1111-1118
22. Traber M.G. Winklhofer-Roob B.M. Roob J.M. et al. Vitamin E kinetics in smokers and nonsmokers Free Radical Biol Med 31 2001 1368-1374
23. Baker H. Handelman G.J. Short S. et al. Comparison of plasma alpha and gamma tocopherol levels following chronic oral administration of either all-rac-alpha-tocopheryl acetate or RRR-alpha-tocopheryl acetate in normal adult male subjects Am J Clin Nutr 43 1986 382-387
24. Lykkesfeldt J. Loft S. Poulsen H.E. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection-are they reliable biomarkers of oxidative stress? Anal Biochem 229 1995 329-335
25. Lykkesfeldt J. Measurement of ascorbic acid and dehydroascorbic acid in biological samples In: Maines M. Costa L.G. Hodson E. Reed D.J. Sipes I.G. (Eds.) Current protocols in toxicology 2002 7.6.1 Wiley New York
26. Sattler W. Mohr D. Stocker R. Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence Methods Enzymol 233 1994 469-489
27. Christen S. Woodall A.A. Shigenaga M.K. Southwell-Keely P.T. Duncan M.W. Ames B.N. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements Alpha-tocopherol: physiological implications Proc Natl Acad Sci USA 94 1997 3217-3222
28. Handelman G.J. Machlin L.J. Fitch K. Weiter J.J. Dratz E.A. Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans J Nutr 115 1985 807-813
29. Zetler G. Seidel G. Siegers C-.P. Iven H. Pharmacokinetics of ascorbic acid in man Eur J Clin Pharmacol 10 1976 273-282
30. Vidgren M. Kumpusalo E. Silvasti M. Mykkanen M. Parviainen M. Absorption of ascorbic acid from a film-coated tablet and from a new enteric-coated pellet preparation in subjects with inadequate plasma levels of ascorbic acid Arzneimittelforschung 42 1992 143-146
31. Siegers C.P. Seidel G. Iven H. Absorption of vitamin C from a delayed-action preparation Med Welt 26 1975 206-209
32. Yung S. Mayersohn M. Robinson J.B. Ascorbic acid absorption in humans: a comparison among several dosage forms J Pharm Sci 71 1982 282-285
33. Kayden H.J. Traber M.G. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans J Lipid Res 34 1993 343-358
34. Traber M.G. Burton G.W. Hughes L. et al. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism J Lipid Res 33 1992 1171-1182
35. Traber M.G. Olivecrona T. Kayden H.J. Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro J Clin Invest 75 1985 1729-1734
36. Traber M.G. Kayden H.J. Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins Am J Clin Nutr 49 1989 517-526
37. Arita M. Sato Y. Miyata A. et al. Human alpha-tocopherol transfer protein: CDNA cloning, expression and chromosomal localization Biochem J 306 1995 437-443
38. Hosomi A. Arita M. Sato Y. et al. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs FEBS Lett 409 1997 105-108