Diabetes mellitus in adults: Association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

Immunology Letters

Volumn 95, Issue 2, 2004, Pages 229-232

  Novota, Peter ^a,b   Cerna, Marie ^a   Kolostova, Katarina ^a   Cejkova, Pavlina ^a   Zdarsky, Emanuel ^a   Novakova, Dana ^a   Kucera, Petr ^a   Novak, Jan ^a   Andel, Michal ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

C peptide (CP); Diabetes mellitus (DM); Glutamic acid decarboxylase (GAD); HLA DQ DR

Indexed keywords

AUTOANTIBODY; C PEPTIDE; GLUTAMATE DECARBOXYLASE; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; INSULIN;

ADULT; AGED; ALLELE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; MALE; MATHEMATICAL COMPUTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SECRETION; RISK;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANTIBODIES; C-PEPTIDE; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED;

EID: 4544225871     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.07.016     Document Type: Article

References (14)

1. B. Newman, J.V. Selby, M.C. King, C. Slemenda, R. Fabsitz, and G.D. Friedman Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins Diabetologia 30 1987 763 768
2. L. Niskanen, J. Karjalainen, O. Siitonen, and M. Uusitupa Metabolic evolution of type 2 diabetes: a 10-year follow-up from the time of diagnosis J Int Med. 236 1994 263 270
3. I. Vauhkonen, L. Niskanen, E. Vanninen, S. Kainulainen, M. Uusitupa, and M. Laakso Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands J Clin Invest. 101 1998 86 96
4. L.C. Groop, G.F. Bottazzo, and D. Doniach Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis Diabetes 35 1986 237 241
5. T. Kobayashi, K. Tamemoto, K. Nakanishi, N. Kato, M. Okubo, H. Kajio, T. Sugimoto, T. Murase, and K. Kosaka Immunogenetic and clinical characterization of slowly progressive IDDM Diab Care 16 1993 780 788
6. T. Tuomi, L.C. Groop, P.Z. Zimmet, M.J. Rowley, W. Knowles, and I.R. Mackay Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease Diabetes 42 1993 359 362
7. S. Caillat-Zucman, H.J. Garchon, J. Timsit, R. Assan, C. Boitard, I. Djilali-Saiah, P. Bougneres, and J.F. Bach Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus J Clin Invest. 90 1992 2242 2250
8. M. Krokowski, J. Bodalski, A. Bratek, C. Boitard, and S. Caillat-Zucman HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population Hum Immunol. 59 1998 451 455
9. G. Gambelunghe, F. Forini, S. Laureti, G. Murdolo, G. Toraldo, F. Santeusanio, P. Brunetti, C.B. Sanjeevi, and A. Falorni Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies Clin Endocrinol (Oxf) 52 2000 565 573
10. C.F. Verge, D. Stenger, E. Bonifacio, P.G. Colman, C. Pilcher, P.J. Bingley, and G.S. Eisenbarth Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop Diabetes 47 1998 1857 1866
11. O. Olerup, and H. Zetterquist HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 h: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation Tissue Antigens 39 1992 225 235
12. O. Olerup, A. Aldener, and A. Fogdell HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 h Tissue Antigens 41 1993 119 134
13. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, Switzerland: Department of Noncommunicable Disease Surveillance, WHO; 1999.
14. M. Cerna, M. Fernandez-Vina, E. Ivaskova, and P. Stastny Comparison of HLA class II alleles in gypsy and Czech populations by DNA typing with oligonucleotide probes Tissue Antigens 39 1992 111