Characteristics of T-cell large granular lymphocyte proliferations associated with neutropenia and inflammatory arthropathy

Arthritis Research and Therapy

Volumn 10, Issue 3, 2008, Pages

  Prochorec Sobieszek, Monika ^a,b   Rymkiewicz, Grzegorz ^c   Makuch Łasica, Hanna ^a   Majewski, Mirosław ^a   Michalak, Katarzyna ^a   Rupiński, Robert ^b   Warzocha, Krzysztof ^a   Maryniak, Renata ^a  

^a INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

^b INSTITUTE OF RHEUMATOLOGY   (Poland)

^c INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD2 ANTIGEN; CD3 ANTIGEN; CD5 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; GRANZYME; IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; LEUKOSIALIN; METHOTREXATE; PREDNISONE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTHROPATHY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; B LYMPHOCYTE; BLOOD CELL COUNT; BONE MARROW BIOPSY; CLINICAL ARTICLE; FELTY SYNDROME; FEMALE; FLOW CYTOMETRY; GENE REARRANGEMENT; GENETIC ANALYSIS; HETERODUPLEX ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LARGE GRANULAR LYMPHOCYTE; LEUKOCYTE COUNT; LOW DRUG DOSE; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOSIS; MALE; MONOTHERAPY; NEUTROPENIA; NEUTROPHIL COUNT; POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SPLENOMEGALY; T CELL LEUKEMIA; BONE MARROW; CELL PROLIFERATION; COMPARATIVE STUDY; IMMUNOLOGY; INFLAMMATION; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; MIDDLE AGED; NEUROPATHIC JOINT DISEASE; PATHOLOGY; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; ARTHROPATHY, NEUROGENIC; BONE MARROW; CELL PROLIFERATION; FEMALE; HUMANS; INFLAMMATION; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; LYMPHOCYTOSIS; MALE; MIDDLE AGED; NEUTROPENIA; T-LYMPHOCYTES;

EID: 45249111161     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2424     Document Type: Article

References (42)

1. Wallis WJ Loughran TP Jr Kadin ME Clark EA Starkebaum GA Polyarthritis and neutropenia associated with circulating large granular lymphocytes Ann Intern Med 1985, 103:357-362 4026084
2. Barton JC Prasthofer EF Egan ML Heck LW Koopman WJ Grossi CE Rheumatoid arthritis associated with expanded populations of granular lymphocytes Ann Intern Med 1986, 104:314-323. 3946976
3. Snowden N Bhavnani M Swinson DR Kendra JR Dennett C Carrington P Walsh S Pumphrey RS Large granular T lymphocytes, neutropenia and polyarthropathy: An underdiagnosed syndrome? Q J Med 1991,78:65-76 1670066
4. Langerak AW Sandberg Y van Dongen JJ Spectrum of T-large granular lymphocyte lymphoproliferations: Ranging from expanded activated effector T cells to T-cell leukaemia Br J Haematol 2003, 123:561-562 10.1046/j.1365-2141.2003.04647.x 14617025
5. Sokol L Loughran TP Jr Large granular lymphocyte leukemia Oncologist 2006, 11: 263-273 10.1634/theoncologist.11-3-263 16549811
6. Chan WC Catovsky D Foucar K Monserrat E T-cell large granular lymphocyte leukemia World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues Lyon: IARC Press Jaffe ES, Harris NL, Stein H, Vardiman JW 2001,197-198
7. Burks EJ Loughran TP Jr Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome Blood Rev 2006, 20: 245-266 10.1016/j.blre.2006.01.003 16530306
8. Loughran TP Jr Clonal diseases of large granular lymphocytes Blood 1993, 82: 1-14 8324214
9. Lamy T Loughran TP Jr Clinical features of large granular lymphocyte leukemia Semin Hematol 2003, 40:185-195 10.1016/S0037-1963(03)00133-1 12876667
10. Dhodapkar MV Li CY Lust JA Tefferi A Phyliky RL Clinical spectrum of clonal proliferations of T-large granular lymphocytes: A T-cell clonopathy of undetermined significance? Blood 1994, 84:1620-1627 8068951
11. Bowman SJ Corrigall V Panayi GS Lanchbury JS Hematologic and cytofluorographic analysis of patients with Felty's syndrome. A hypothesis that a discrete event leads to large granular lymphocyte expansions in this condition Arthritis Rheum 1995, 38:1252-1259 10.1002/ art.1780380913 7575720
12. Starkebaum G Loughran TP Jr Gaur LK Davis P Nepom BS Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis Arthritis Rheum 1997, 40:624-626 10.1002/art.1780400406 9125243
13. Gonzales-Chambers R Przepiorka D Winkelstein A Agarwal A Starz TW Kline WE Hawk H Lymphocyte subsets associated with T cell receptor beta-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia Arthritis Rheum 1992, 35:516-520 10.1002/art.1780350505 1315549
14. Loughran TP Jr Starkebaum G Kidd P Neiman P Clonal proliferation of large granular lymphocytes in rheumatoid arthritis Arthritis Rheum 1988, 31:31-36 10.1002/art.1780310105 3345230
15. Bowman SJ Bhavnani M Geddes C Corrigall V Boylston AW Panayi GS Lanchbury JS Large granular lymphocyte expansions in patients with Felty's syndrome: Analysis using anti-T cell receptor Vbeta-specyfic monoclonal antibodies Clin Exp Immunol 1995, 101:18-24 1553309 7621587
16. Arnett FC Edworthy SM Bloch DA McShane DJ Fries JF Cooper NS Healey LA Kaplan SR Liang MH Luthra HS Medsger TA Jr Mitchell DM Neustadt DH Pinals RS Schaller JG Sharp JT Wilder RL Hunder GG The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 10.1002/ art.1780310302 3358796
17. van Dongen JJ Langerak AW Brüggemann M Evans PA Hummel M Lavender FL Delabesse E Davi F Schuuring E García-Sanz R van Krieken JH Droese J González D Bastard C White HE Spaargaren M González M Parreira A Smith JL Morgan GJ Kneba M Macintyre EA Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 Leukemia 2003, 12:2257-2317 14671650 10.1038/ sj.leu.2403202
18. Campion G Maddison PJ Goulding N James I Ahern MJ Watt I Sansom D The Felty syndrome: A case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations Medicine (Baltimore) 1990, 69:69-80 1969604
19. Osuji N Matutes E Tjonnfjord G Grech H Del Giudice I Wotherspoon A Swansbury JG Catovsky D T-cell large granular lymphocyte leukemia. A report on the treatment of 29 of patients and a review of the literature Cancer 2006, 107:570-578 10.1002/cncr.22032 16795070
20. Davey MP Starkebaum G Loughran TP Jr CD3+ leukemic large granular lymphocytes utilize diverse T-cell receptor V beta genes Blood 1995, 85:146-150 7803792
21. Wlodarski MW Schade AE Maciejewski JP T-large granular lymphocyte leukemia: Current molecular concepts Hematology 2006, 11:245-256 10.1080/ 10245330600774793 17178663
22. Fitzgerald JE Ricalton NS Meyer AC West SG Kaplan H Behrendt C Kotzin BL Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis J Immunol 1995, 154:3538-3547 7897233
23. Bigouret V Hoffmann T Arlettaz L Villard J Colonna M Ticheli A Gratwohl A Samii K Chapuis B Rufer N Roosnek E Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors Blood 2003, 101:3198-3204 10.1182/blood-2002-08-2408 12480700
24. Hingorani R Monteiro J Furie R Chartash E Navarrete C Pergolizzi R Gregersen PK Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients J Immunol 1996, 156:852-858 8543842
25. Semenzato G Zambello R Starkebaum G Oshimi K Loughran TP Jr The lymphoproliferative disease of granular lymphocytes: Updated criteria for diagnosis Blood 1997, 89:256-260 8978299
26. Morice WG Kurtin PJ Tefferi A Hanson CA Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B Blood 2002, 99:268-274 10.1182/blood.V99.1.268 11756181
27. Costes V Duchayne E Taib J Delfour C Rousset T Baldet P Delsol G Brousset P Intrasinusoidal bone marrow infiltration: A common growth pattern for different lymphoma subtypes Br J Haematol 2002, 119:916-922 10.1046/j.1365-2141.2002.03934.x 12472568
28. Osuji N Beiske K Randen U Matutes E Tjonnfjord G Catovsky D Wotherspoon A Characteristic appearances of the bone marrow in T-cell large granular lymphocyte leukaemia Histopathology 2007, 50:547-554 10.1111/ j.1365-2559.2007.02656.x 17394489
29. Lundell R Hartung L Hill S Perkins SL Bahler DW T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules Am J Clin Pathol 2005, 124:937-946 10.1309/PH7X-78HF-4FW4-PRKW 16416744
30. O'Keefe CL Plasilova M Wlodarski M Risitano AM Rodriguez AR Howe E Young NS Hsi E Maciejewski JP Molecular analysis of TCR clonotypes in LGL: A clonal model for polyclonal responses J Immunol 2004, 172:1960-1969 14734782
31. Langerak AW Bemd van Den R Wolvers-Tettero IL Boor PP van Lochem EG Hooijkaas H van Dongen JJ Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalfabeta T-cell proliferations Blood 2001, 98:165-173 10.1182/blood.V98.1.165 11418476
32. Nearman ZP Wlodarski M Jankowska AM Howe E Narvaez Y Ball E Maciejewski JP Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias Br J Haematol 2007, 136:237-248 10.1111/j.1365-2141.2006.06429.x 17156396
33. Bowman SJ Hall MA Panayi GS Lanchbury JS T cell receptor alpha-chain and beta-chain junctional region homology in clonal CD3+, CD8+ T lymphocyte expansions in Felty's syndrome Arthritis Rheum 1997, 40:615-623 10.1002/ art.1780400405 9125242
34. Wlodarski MW O'Keefe C Howe EC Risitano AM Rodriguez A Warshawsky I Loughran TP Jr Maciejewski JP Pathologic clonal cytotoxic T-cell responses: Nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia Blood 2005, 106:2769-2780 10.1182/ blood-2004-10-4045 15914562
35. Garrido P Ruiz-Cabello F Bárcena P Sandberg Y Cantón J Lima M Balanzategui A González M López-Nevot MA Langerak AW García-Montero AC Almeida J Orfao A Monoclonal TCR-Vbeta13.1+/ CD4+/NKa+/CD8-/+ dim T-LGL lymphocytosis: Evidence for an antigen-driven chronic T-cell stimulation origin Blood 2007, 109:4890-4898 10.1182/ blood-2006-05-022277 17303697
36. Sandberg Y Almeida J Gonzalez M Lima M Bárcena P Szczepañski T van Gastel-Mol EJ Wind H Balanzategui A van Dongen JJ Miguel JF Orfao A Langerak AW TCR gammadelta+ large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCR gammadelta+ T-cells Leukemia 2006, 20:505-513 10.1038/sj.leu.2404112 16437145
37. Engels K Oeschger S Hansmann ML Hillebrand M Kriener S Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates Hum Pathol 2007, 38:1402-1411 10.1016/j.humpath.2007.02.009 17560629
38. Lima M Almeida J Santos AH dos Anjos Teixeira M Alguero MC Queirós ML Balanzategui A Justiça B Gonzalez M San Miguel JF Orfão A Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3+/TCR-alfabeta+ large granular lymphocytes: Utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol 2001, 159:1861-1868 1867049 11696446
39. Starkebaum G Arend WP Nardella FA Gavin SE Characterization of immune complexes and immunoglobulin G antibodies reactive with neutrophils in the sera of patients with Felty's syndrome J Lab Clin Med 1980, 96:238-251 6772719
40. Perzova R Loughran TP Jr Constitutive expression of Fas ligand in large granular lymphocyte leukaemia Br J Haematol 1997, 97:123-126 10.1046/ j.1365-2141.1997.d01-2113.x 9136951
41. Maciejewski J Selleri C Anderson S Young NS Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro Blood 1995, 85:3183-3190 7538820
42. Bank I Cohen L Kneller A De Rosbo NK Book M Ben-Nun A Aberrant T-cell receptor signaling of interferon-gamma- and tumor necrosis factor-alfa-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia Scand J Immunol 2003, 58:89-98 10.1046/ j.1365-3083.2003.01272.x 12828563