Preoperative oral administration of pentoxifylline ameliorates respiratory index after cardiopulmonary bypass through decreased production of IL-6

Acta Medica Okayama

Volumn 62, Issue 2, 2008, Pages 69-74

  Otani, Satoru ^a   Kuinose, Masahiko ^b   Murakami, Takashi ^c   Saito, Shinya ^d   Iwagaki, Hiromi ^e   Tanaka, Noriaki ^e   Tanemoto, Kazuo ^f  

^a IWAKUNI NATIONAL HOSPITAL   (Japan)

^b Sakakibara Hospital   (Japan)

^c KOCHI WOMEN S UNIVERSITY   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION FUKUYAMA MEDICAL CENTER   (Japan)

^e OKAYAMA UNIVERSITY   (Japan)

^f KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

CPB; IL 6; Pentoxifylline; Respiratory index; SIRS

Indexed keywords

INTERLEUKIN 6; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR;

ADULT; AGED; ARTICLE; BREATHING; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PREOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; AGED; CARDIOPULMONARY BYPASS; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; PREOPERATIVE CARE; RESPIRATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 45149127316     PISSN: 0386300X     EISSN: 0386300X     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ohata T, Sawa Y, Kadova K, Masai T, Ichikawa H and Matsuda H: Effect of cardiopulmonary bypass under tepid temperature on inflammatory reactions. Ann Thorac Surg (1997) 64: 124-128.
2. Edmunds LH Jr: Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg (1998) 66 (suppl 5): S12-S16.
3. Asimakopoulos G and Taykor KM: Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecule. Ann Thorac Surg (1998) 66: 2135-2144.
4. Westaby S: Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit. Intensive Care Med (1987) 13: 89-95.
5. Downing SW and Edmunds LH Jr: Release of vasoactive substances during cardiopulmonary bypass. Ann Thorac Surg (1992) 54: 1236-1243.
6. Baigrie RJ, Lamont PM, Dallman M and Morris P: The release of interleukin-1 beta precedes that of interleukin-6 in patients undergoing normothermic cardiopulmonary bypass. Lymphokine and Cytokine Res (1991) 10: 253-256.
7. Frering B, Philip I, Dehoux M, Rolland C, Langlois JM and Desmonts JM: Circulating cytokines in patients undergoing normothermic cardiopulmonary bypass. J Thorac Cardiovasc Surg (1994) 108: 636-641.
8. Cruickshank AM, Fraser WD, Burns HJ, Van Damme J and Shenkin A: Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci (Lond) (1990) 79: 161-165.
9. Tracey KJ, Morgello S, Koplin B, Fahey TJ 3rd, Fox J, Aledo A, Monogue KR and Cerami A: Metabolic effects of cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia. J Clin Invest (1990) 86: 2014-2024.
10. Engelberts I, Stephens S, Francot GJ, van der Linden CJ and Buurman WA: Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids. Lancet (1991) 338: 515-516.
11. Kishimoto T, Akira S and Taga T: Interleukin-6 and its receptor. A paradigm for cytokines. Science (1992) 258: 593-597.
12. Barton BE and Jackson JV: Protective role of interleukin-6 in the lipopolysaccharide- galactosamine septic shock model. Infect lmmun(1993)61: 1496-1499.
13. Ruvolo G, Greco E, Speziale G, Tritapepe L, Mrerino B, Mollace V and Nistico G: Nitric oxide formation during cardiopulmonary bypass. Ann Thorac Surg (1994) 57: 1055-1057.
14. Ungureanu-Longrois D, Balligand JL, Kelly RA and Smith TW: Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes. J Mol Cell Cardiol (1995) 27: 155-167.
15. Kubes P, Suzuki M and Granger DN: Nitric oxide; an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA (1991) 88: 4651-4655.
16. Niu XF, Smith CW and Kubes P: Intercellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Cir Res (1994) 74: 1133-1140.
17. Kiziltepe U, Tunctan B, Eyileten ZB, Sirlak M, Arikbuku M, Tasoz R, Uysalel A and Ozyurda U: Efficiency of L-arginine enriched cardiplegia and non-cardioplegic reperfusion in ischemic hearts. Int J Cardiol (2004) 97: 93-100.
18. He GW: Endothelial function related to vascular tone in cardiac surgery. Heart Lung Circ (2005) 14: 13-18.
19. Mandell GL: Cytokines, Phagocytes and Pentoxifylline. J Cardiovasc Pharmacol (1995) 25 (Suppl 2): S20-S22.
20. Strieter RM, Remick DG, Ward PA, Spengler RN, Lynch JP 3 rd, Larrick J and Kunkel SL: Cellular and molecular regulation of tumor necrosis factor α production by pentoxifylline. Biochem Biomed Res Commun (1988) 155: 1230-1236.
21. Bienvenu J, Coulon L, Barbier Y, Barbier M, Doche C, Lepape A and Guenounou M: Study of pentoxifylline induced modulation of TNF-a and interleukin-6 secretion in healthy and septic patients by the use of annex vivo model on whole blood. Nouv Rev Fr Hematol (1992) 34 (suppl): S65-67.
22. Bessler H, Gilgal R, Djaldetti M and Zahavi I: Effects of pentoxifylline on the phagocytic activity, cAMP levels and superoxide anion production by monocytes and polymorphonuclear cells. J Leukocy Biol (1986) 40: 747-754.
23. Alegre ML, Gastadello K, Abramowicz D, Kinnaert P, Vereerstraeten P, Pauw LD, Vandenabeele P, Moser M, Leo O and Goldman M: Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome. Transplantation (1991) 52: 674-679.
24. Rott O, Cash E and Fleischer B: Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats. Eur J Immunol (1993) 23: 1745-1751.
25. Clark SC, Rao JN, Flecknell PA and Dark JH: Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury. J Thorac Cardiovasc Surg (2003) 126: 2052-2057.
26. Iskesen I, Saribulbul O, Cerrahoglu M, Onur E, Destan B and Sirin BH: Pentoxifylline affects cytokine reaction in cardiopulmonary bypass. Heart Surg Forum (2006) 9: E883-887.
27. Ustunsoy H, Sivrikoz MC, Tarakcioglu M, Bakir K, Guldur E and Celkan MA: The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass. J Card Surg (2006) 21: 57-61.
28. Boldt J, Brosch C, Lehmann A, Haisch G, Lang J and Isgro F: Prophylactic use of pentoxifylline on inflammation in elderly cardiac surgery patients. Ann Thorac Surg (2001) 71: 1524-1529.
29. Thanhauser A, Reiling N, Bohle A, Toellner KM, Duchrow M, Scheel D, Schluter C, Ernst M, Flad HD and Ulmer AJ: Pentoxifylline: a potent inhibitor of IL-2 and IFN-γ biosynthesis and BCG-induced cytotoxicity. Immunology (1993) 80: 151-156.
30. Baumann H and Gauldie J: The acute phase response. Immunol Today (1994) 15: 74-80.
31. Barton BE and Jackson JV: Protective role of interleukin-6 in the lipopolysaccharide-galactosamine septic shock model. Infect lmmun (1993) 61: 1496-1499.
32. Kawamura T, Nara N, Kadosaki M, Inada K and Endo S: Prostaglandin E1 reduces myocardial reperfusion injury by inhibiting proinflammatory cytokines production during cardiac surgery. Crit Care Med (2000) 28: 2201-2208.
33. Murakami T, Iwagaki H, Saito S, Ohtani S, Kuinose M, Tanaka N and Tanemoto K: Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system. J Int Med Res (2005) 33: 133-149.
34. Ascione R, Lloyd CT, Underwood MJ, Lotto AA, Pitsis AA and Angelini GD: Inflammatory response after coronary revascularization with or without cardiopulmonary bypass. Ann Thorac Surg (2000) 69: 1198-1204.
35. Chello M, Mastroroberto P, Quirino A, Cuda G, Perticone F, Cirillo F and Covino E: Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass. Ann Thorac Surg (2002) 73: 123-130.
36. Chapelier A, Reignier J, Mazmanian M, Detruit H, Dartevelle P, Parquin F, Cerrina J, Ladurie FLR and Herve P: Pentoxifylline and lung ischemia - reperfusion injury: Application to lung transplantation. J Cardiovasc Pharamacol (1995) 25: 130-133.