Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury

Journal of Thoracic and Cardiovascular Surgery

Volumn 126, Issue 6, 2003, Pages 2052-2057

  Clark, Stephen C ^a   Rao, Jagan N ^a   Flecknell, Paul A ^b   Dark, John H ^a  

^a FREEMAN HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; LEUKOCYTE ELASTASE; MALONALDEHYDE; PENTOXIFYLLINE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GAS EXCHANGE; LEUKOCYTE; LUNG INJURY; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE;

EID: 0347064244     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(03)01187-5     Document Type: Article

References (18)

1. Fishbein MC. Reperfusion injury [review]. Clin Cardiol. 1990;13:213-7.
2. Bando K, Schueler S, Cameron DE, DeValeria PA, Hatanaka M, Casale AS, et al. Twelve-hour cardiopulmonary preservation using donor core cooling, leukocyte depletion, and liposomal superoxide dismutase. J Heart Lung Transplant. 1991;10:304-9.
3. Levine AJ, Parkes K, Rooney S, Bonser RS. Reduction of endothelial injury after hypothermic lung preservation by initial leukocyte-depleted reperfusion. J Thorac Cardiovasc Surg. 2000;120:47-54.
4. Lick SD, Brown PS Jr, Kurusz M, Vertrees RA, McQuitty CK, Johnston WE. Technique of controlled reperfusion of the transplanted lung in humans. Ann Thorac Surg. 2000;69:910-2.
5. Clark SC, Sudarshan CD, Khanna R, Roughan JV, Flecknell PA, Dark JH. A new porcine model of reperfusion injury after lung transplantation. Lab Anim. 1999;33:135-42.
6. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ. 1990;300:230-5.
7. Clark SC, Sudarshan C, Roughan J, Flecknell PA, Dark JH. Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. J Thorac Cardiovasc Surg. 1999;117:556-64.
8. Chapelier A, Reignier J, Mazmanian M, Dulmet E, Libert JM, Dartevelle P, et al. Amelioration of reperfusion injury by pentoxifylline after lung transplantation. The Universite Paris-Sud Lung Transplant Group. J Heart Lung Transplant. 1995;14:676-83.
9. Okabayashi K, Aoe M, DeMeester SR, Cooper JD, Patterson GA. Pentoxifylline reduces lung allograft reperfusion injury. Ann Thorac Surg. 1994;58:50-6.
10. Schmid RA, Yamashita M. Effect of pentoxifylline in a canine and porcine model of pulmonary allograft reperfusion injury. J Heart Lung Transplant. 1997;16:366-7.
11. Gourlay T, Fleming J, Taylor KM. Laboratory evaluation of the Pall LG6 leukocyte depleting arterial line filter. Perfusion. 1992;7:131-40.
12. Gourlay T, Fleming J, Taylor KM. The effects of pulsatile flow on the leukocyte depleting qualities of the Pall LG6 leukocyte depleting arterial line filter: a laboratory investigation. Perfusion. 1992;7:227-32.
13. Schueler S, De Valeria PA, Hatanaka M, Cameron DE, Bando K, Zeebley M, et al. Successful twenty-four-hour lung preservation with donor core cooling and leukocyte depletion in an orthotopic double lung transplantation model. J Thorac Cardiovasc Surg. 1992;104:73-82.
14. Ross SD, Tribble CG, Gaughen JR Jr, Shockey KS, Parrino PE, Kron IL. Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation. Ann Thorac Surg. 1999;67:1428-34.
15. Noel C, Copin MC, Hazzan M, Labalette M, Susen S, Lelievre G, et al. Immunomodulatory effect of pentoxifylline during human allograft rejection: involvement of tumour necrosis factor alpha and adhesion molecules. Transplantation. 2000;69:1102-7.
16. Schratzberger P, Dunzendorfer S, Reinisch N, Buratti T, Kahler CM, Tilg H, et al. Mediator-dependent effects of pentoxifylline on endothelium for transmigration of neutrophils. Immunopharmacology. 1999;41:65-75.
17. Currie MS, Rao KM, Padmanabhan J, Jones A, Crawford J, Cohen HJ. Stimulus specific effects of pentoxifylline on neutrophil CR3 expressions, degranulation and superoxide production. J Leukoc Biol. 1990;47:244-50.
18. Yamashita M, Schmid RA, Okabayashi K, Ando K, Kobayashi J, Cooper JD, et al. Pentoxifylline in flush solution improves early lung allograft function. Ann Thorac Surg. 1996;61:1055-61.